MLB Game Preview: St. Louis Cardinals (29-22) vs. Milwaukee Brewers (30-20)

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Milwaukee Brewers logo

First Pitch: 7:10 PM CT

Venue: American Family Field, Milwaukee, Wisconsin

Surface: Retractable Roof (roof status TBD)

Probable Pitchers:

  • STL — Matthew Liberatore (LHP)
  • MIL — Jacob Misirowski (RHP)

Weather Outlook (Milwaukee, WI)

Note: American Family Field’s retractable roof reduces weather impact, but conditions influence roof decision.

  • Temperature: 70–73°F
  • Wind: 9–12 mph blowing out to left‑center
  • Humidity: ~55%
  • Precipitation: 20% — slight chance of showers
  • Roof Expectation: Likely closed or partially closed, minimizing wind effect
  • Ballpark Impact: If roof closed → neutral; if open → slight boost for RH power

Injury Report

St. Louis Cardinals

  • Nolan Arenado — Day‑to‑day (back tightness; expected to play)
  • Lars Nootbaar — OUT (oblique strain)
  • Tommy Edman — OUT (wrist surgery recovery)
  • Giovanny Gallegos — OUT (shoulder)
  • Riley O’Brien — Probable (bullpen availability)

Milwaukee Brewers

  • Christian Yelich — Day‑to‑day (knee soreness)
  • Jackson Chourio — Probable (minor ankle tweak)
  • Robert Gasser — OUT (elbow)
  • Devin Williams — OUT (back)
  • Garrett Mitchell — OUT (shoulder)

Team Records & Recent Form

St. Louis Cardinals (29–22)

  • Last 10: 6–4
  • Road Record: 13–12
  • Run Differential: +18
  • Trend: Pitching staff stabilizing; offense inconsistent but clutch
  • Key Note: Cardinals have allowed 3 runs or fewer in 5 of last 7 wins

Milwaukee Brewers (30–20)

  • Last 10: 7–3
  • Home Record: 16–9
  • Run Differential: +31
  • Trend: Rotation performing above expectations; bullpen shaky without Williams
  • Key Note: Brewers have scored 5+ runs in 7 of last 10

Pitching Matchup Breakdown

STL — Matthew Liberatore (LHP)

  • 2026 Stats:
    • ERA: ~4.02
    • WHIP: 1.29
    • K/9: 8.7
    • HR/9: 1.0
  • Profile: Curveball‑first lefty; mixes sinker and slider
  • Strengths: Generates soft contact; effective vs. LHB
  • Weaknesses: Command inconsistency; RH hitters lift the ball well
  • Matchup Fit: Brewers’ RH core (Contreras, Hoskins, Chourio) presents challenges

MIL — Jacob Misirowski (RHP)

  • 2026 Stats:
    • ERA: ~3.48
    • WHIP: 1.17
    • K/9: 10.1
    • HR/9: 0.9
  • Profile: Power fastball (97–99), sharp slider, emerging changeup
  • Strengths: Misses bats; elite vs. LHB
  • Weaknesses: Can be hittable early; pitch count climbs quickly
  • Matchup Fit: Cardinals’ RH bats (Goldschmidt, Arenado, Winn) match up better than their LHB

Key Player Matchups

Cardinals Hitters vs. Misirowski

  • Paul Goldschmidt: .295 career vs. high‑velocity RHP; strong matchup
  • Nolan Arenado: If active, elite vs. sliders; good matchup
  • Masyn Winn: Contact‑oriented; could exploit fastball command lapses

Brewers Hitters vs. Liberatore

  • William Contreras: .310 career vs. LHP; excellent matchup
  • Rhys Hoskins: Pull‑side power; roof‑open scenario boosts HR probability
  • Jackson Chourio: Speed + lift; dangerous vs. curveball‑heavy pitchers

Series History

  • 2024–2026 Combined: Brewers lead 17–15
  • At American Family Field: Brewers have won 6 of last 9
  • Scoring Trend: 5 of last 7 meetings have gone OVER

Betting Trends

St. Louis Cardinals

  • 5–2 last 7 as a road underdog
  • UNDER 6–3 last 9 games
  • Liberatore: Cardinals are 5–4 in his starts

Milwaukee Brewers

  • 7–2 last 9 at home
  • OVER 7–3 last 10 games
  • Misirowski: Brewers are 6–3 in his starts

Head‑to‑Head

  • Brewers 4–1 last 5 meetings
  • OVER 5–2 last 7 in Milwaukee

Game Odds

St. Louis Cardinals           7.5

Milwaukee Brewers       – 210

Odds Courtesy of Sports Odds Direct as of Sunday, May 24, 2026