MLB Game Preview: St. Louis Cardinals (28-21) vs. Cincinnati Reds (26-24) Double-Header

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Cincinnati Reds logo

Game 1 First Pitch: 12:10 PM ET

Game 2 First Pitch: Approximately 6:40 PM ET (or 45 minutes after Game 1 ends)

Broadcast: Bally Sports Ohio / Bally Sports Midwest

WEATHER OUTLOOK — GREAT AMERICAN BALL PARK

  • Temperature: 77–82°F across the day
  • Wind: 8–12 mph out to right-center
  • Humidity: 60–65%
  • Rain: <10% (dry day expected)
  • Impact:
    • GABP is already one of MLB’s top HR parks
    • Warm temps + wind out = significant boost to left-handed power
    • Expect elevated run-scoring conditions in both games

INJURY REPORT

St. Louis Cardinals

  • Nolan Arenado — Probable (minor back tightness)
  • Willson Contreras — OUT (forearm fracture; IL)
  • Tommy Edman — OUT (wrist surgery; IL)
  • Steven Matz — OUT (shoulder strain; IL)

Cincinnati Reds

  • Matt McLain — OUT (shoulder surgery; season-ending)
  • TJ Friedl — OUT (hamstring strain; IL)
  • Nick Lodolo — Probable (fatigue; expected to pitch in upcoming series, not today)
  • Brandon Williamson — OUT (lat strain; IL)

PROBABLE PITCHING MATCHUPS

GAME 1 — 12:10 PM ET

St. Louis: RHP Kyle Leahy

  • 2026 Stats: 2–2, 4.41 ERA, 1.33 WHIP
  • Profile:
    • Fastball 94–96 mph, decent ride
    • Slider is his out pitch
    • Fly-ball tendencies are dangerous in Cincinnati
  • Weakness:
    • Struggles vs. left-handed hitters (.286 BAA)
    • High HR/FB rate (14%)

Cincinnati: RHP Chris Paddack

  • 2026 Stats: 3–3, 3.98 ERA, 1.25 WHIP
  • Profile:
    • Changeup-heavy righty
    • Excellent command; low walk rate
    • Keeps ball down better than earlier in his career
  • Matchup Advantage:
    • Cardinals struggle vs. elite changeups
    • Paddack has been strong at home (3.21 ERA)

GAME 2 — 6:40 PM ET (Projected)

St. Louis: RHP Tink Hence (expected)

  • 2026 Stats: 1–1, 3.72 ERA, 1.18 WHIP
  • Profile:
    • Electric young arm
    • Fastball 96–98 mph, sharp curve
    • High strikeout upside
  • Concern:
    • First career start at GABP — tough environment
    • Reds hit velocity well

Cincinnati: RHP Chase Petty

  • 2026 Stats: 2–2, 4.09 ERA, 1.29 WHIP
  • Profile:
    • Heavy sinker (97 mph)
    • Generates ground balls
    • Still developing secondary pitches
  • Matchup Advantage:
    • Cardinals right-handed core (Goldschmidt, Arenado) hits sinkers well
    • Vulnerable to lefty bats

TEAM RECORDS & RECENT FORM

St. Louis Cardinals (28–21)

  • Last 10: 7–3
  • Road Record: 13–11
  • Run Differential: +19
  • Trend: Pitching stabilizing; offense improving after slow April
  • Strength: Top-5 in MLB in hard-hit rate over last 15 games
  • Weakness: Bullpen depth tested in doubleheaders

Cincinnati Reds (26–24)

  • Last 10: 5–5
  • Home Record: 14–12
  • Run Differential: +6
  • Trend: Offense streaky; pitching inconsistent
  • Strength: Athletic lineup; aggressive baserunning
  • Weakness: Missing key bats (McLain, Friedl)

KEY PLAYER MATCHUPS

Cardinals Hitters vs. Reds Pitching

  • Paul Goldschmidt: .310 career vs sinkers; strong matchup vs Petty
  • Nolan Arenado: Heating up (.333 last 7 games)
  • Lars Nootbaar: Best matchup vs Paddack’s fastball/changeup combo
  • Masyn Winn: Elite contact; thrives vs command pitchers

Reds Hitters vs. Cardinals Pitching

  • Elly De La Cruz: HR/SB threat; Leahy’s fly-ball profile is dangerous
  • Spencer Steer: .295 at home; excellent vs sliders
  • Christian Encarnacion-Strand: Power bat boosted by weather
  • Jeimer Candelario: Switch-hitter with strong OBP

SERIES HISTORY

  • 2024–2026: Cardinals lead 17–14
  • At GABP: Reds have won 5 of last 8
  • Cardinals swept a doubleheader here in 2023, Reds swept one in 2025

BETTING TRENDS

St. Louis

  • 6–2 in last 8 road games
  • 5–1 in last 6 vs NL Central
  • Over is 4–1 in last 5

Cincinnati

  • 4–1 in last 5 home games
  • 6–2 in last 8 as underdog
  • Over is 7–3 in last 10 at GABP

GAME 1 ODDS

St. Louis Cardinals           9.5

Cincinnati Reds                 – 109

GAME 2 ODDS

St. Louis Cardinals           – 106

Cincinnati Reds                 9.5

Odds Courtesy of Sports Odds Direct as of Friday, May 22, 2026

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Profile: A dedicated Major League Baseball analyst with a comprehensive understanding of the sport’s strategic, statistical, and developmental layers. This columnist delivers in‑depth coverage that blends advanced metrics, scouting insight, and historical context to illuminate the trends shaping today’s game. Background: With extensive experience following MLB at both the team and league levels, the columnist has contributed to national sports outlets, digital platforms, and radio segments focused on roster construction, player evaluation, and organizational philosophy. A background in sports journalism and analytics supports a disciplined approach to breaking down performance, interpreting data, and tracking long‑term competitive cycles. Signature Coverage Areas: Game previews and pitching‑matchup analysis Advanced statistical breakdowns and sabermetric insights Prospect evaluation, farm‑system trends, and player development Trade‑deadline movement, free‑agency analysis, and front‑office strategy Historical context and postseason features Style & Approach: The writing emphasizes clarity, accuracy, and accessibility — translating complex data and tactical nuance into insights that resonate with both traditional fans and analytically minded readers. Each column reflects a commitment to balanced reporting, thoughtful evaluation, and a deep appreciation for the evolving landscape of Major League Baseball.