MLB Game Preview: San Diego Padres (24-16) vs. Milwaukee Brewers (22-16)

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Milwaukee Brewers logo

First Pitch: 6:40 p.m. CT / 4:40 p.m. PT

Venue: American Family Field — Milwaukee, Wisconsin

Surface: Grass (retractable roof environment)

Capacity: 41,900

Weather Forecast (Milwaukee, WI)

Note: American Family Field’s retractable roof reduces weather impact, but conditions influence roof decision.

  • Temperature: 58–61°F
  • Wind: 8–12 mph blowing in from left
  • Humidity: ~62%
  • Rain Probability: 20%
  • Roof Expectation: Likely closed due to cool temps and light rain risk
  • Weather Impact:
    • If closed: neutral hitting environment
    • If open: wind slightly suppresses RH power

Injury Report

San Diego Padres

  • Fernando Tatis Jr. — Probable (minor hip soreness, expected to play)
  • Xander Bogaerts — OUT (shoulder surgery, long-term)
  • Ha-Seong Kim — Day-to-day (wrist bruise)
  • Joe Musgrove — OUT (elbow inflammation)
  • Robert Suarez — Healthy (closer available)

Milwaukee Brewers

  • Christian Yelich — Day-to-day (back tightness, trending toward playing)
  • William Contreras — Healthy
  • Jackson Chourio — Probable (quad tightness)
  • DL Hall — OUT (forearm strain)
  • Wade Miley — OUT (Tommy John recovery)

Team Records & Form

San Diego Padres (24–16)

  • Last 10: 7–3
  • Road Record: 12–8
  • Run Differential: +27
  • Recent Form:
    • Offense averaging 5.3 runs over last 10
    • Bullpen ERA top‑10 in MLB
    • Rotation stabilizing despite Musgrove’s absence

Milwaukee Brewers (22–16)

  • Last 10: 5–5
  • Home Record: 11–7
  • Run Differential: +9
  • Recent Form:
    • Offense inconsistent but dangerous at home
    • Bullpen strong late, especially in 8th–9th innings
    • Rotation depth tested by injuries

Probable Starting Pitchers

San Diego — RHP Dylan Cease (4–2, 3.21 ERA)

  • WHIP: 1.09
  • K/BB: 58/14
  • Strengths:
    • Elite swing‑and‑miss slider
    • Dominant vs RH hitters
  • Weaknesses:
    • Occasional command lapses
  • Matchup Outlook:
    • Brewers’ lineup has high K-rate vs elite velocity
    • Roof closed favors Cease’s breaking ball

Milwaukee — RHP Freddy Peralta (3–2, 3.77 ERA)

  • WHIP: 1.18
  • K/BB: 52/16
  • Strengths:
    • High-spin fastball, excellent at home
  • Weaknesses:
    • Prone to HRs when behind in counts
  • Matchup Outlook:
    • Padres’ RH bats (Tatis, Machado) match up well
    • Peralta’s fastball can be punished if elevated

Key Player Matchups

Fernando Tatis Jr. (SD) vs. Freddy Peralta

  • Tatis hitting .309 vs RHP
  • Peralta allows 1.2 HR/9 to RH hitters
  • Advantage: Tatis

William Contreras (MIL) vs. Dylan Cease

  • Contreras excels vs high-velo fastballs
  • Cease’s slider may neutralize him
  • Advantage: Even

Manny Machado (SD) vs. Brewers Bullpen

  • Machado hitting .333 in late innings
  • Brewers bullpen top‑5 in WHIP
  • Advantage: Slight Brewers

Jackson Chourio (MIL) vs. Padres Outfield

  • Chourio’s speed vs SD’s average defensive range
  • Advantage: Chourio

Series History

  • 2025 Season: Padres won 4 of 6
  • Last 10 Meetings: Padres lead 7–3
  • At American Family Field: Brewers lead 12–11 since 2015
  • Trend: Games tend to be low-scoring when Cease or Peralta pitches

Betting Trends

San Diego

  • 6–1 in last 7 road games
  • Under is 8–3 in Cease’s last 11 starts
  • Padres 10–4 vs teams above .500

Milwaukee

  • 5–1 in last 6 home games
  • Under is 7–2 in last 9 Peralta starts at home
  • Brewers 4–1 in last 5 vs NL West

Head-to-Head

  • Under is 6–2 in last 8 meetings
  • Padres have won 4 straight in Milwaukee

Game Odds

San Diego Padres             9

Milwaukee Brewers       – 122

Odds Courtesy of Sports Odds Direct as of Monday, May 11, 2026