MLB Game Preview: Detroit Tigers (31-17) vs. St. Louis Cardinals (27-21)

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St. Louis Cardinals logo

The Detroit Tigers and St. Louis Cardinals face off in the second game of their three-game series on Tuesday, May 20, 2025, at Busch Stadium in St. Louis, Missouri. The Cardinals dominated Game 1, securing an 11-4 victory, while the Tigers look to bounce back behind ace Tarik Skubal.

Game Details

  • Matchup: Detroit Tigers (31-17) vs. St. Louis Cardinals (27-21)
  • Date: Tuesday, May 20, 2025
  • Time: 7:45 PM ET
  • Venue: Busch Stadium, St. Louis, MO
  • TV Broadcast: FanDuel Sports Network Detroit

Team Breakdown

Detroit Tigers (31-17, 1st in AL Central)

The Tigers enter this matchup with the best record in MLB, despite their loss in Game 1. Detroit’s offense has been powered by Spencer Torkelson, who leads the team with 12 home runs and 38 RBIs. Riley Greene has also been a key contributor, hitting .342 over his last 10 games.

Detroit’s pitching staff has been one of the best in baseball, and they will rely on Tarik Skubal, who has struck out 11 or more batters in three of his last four starts.

St. Louis Cardinals (27-21, 2nd in NL Central)

The Cardinals have been red-hot, winning 12 of their last 14 games while outscoring opponents 74-32 in that stretch. Lars Nootbaar leads the team with seven home runs, while Ivan Herrera has been on fire, going 15-for-33 with four doubles, a home run, and nine RBIs over his last 10 games.

St. Louis will send Erick Fedde to the mound, who has been dominant, throwing 14 2/3 consecutive scoreless innings.

Probable Pitchers

Detroit Tigers: Tarik Skubal (LHP)

  • Season Stats: 4-2, 2.67 ERA, 0.93 WHIP, 71 K
  • Last Start: 7 IP, 1 ER, 12 K vs. Toronto
  • Key Strength: High strikeout rate and ability to control the game

St. Louis Cardinals: Erick Fedde (RHP)

  • Season Stats: 3-3, 3.44 ERA, 1.30 WHIP, 32 K
  • Last Start: 6 IP, 0 ER, 7 K vs. Pittsburgh
  • Key Strength: Consistency and ability to limit runs

Key Matchups

Spencer Torkelson vs. Erick Fedde

  • Torkelson has been Detroit’s most dangerous hitter, ranking 7th in MLB in home runs.
  • Fedde has been dominant, making this a crucial battle.

Lars Nootbaar vs. Tarik Skubal

  • Nootbaar leads St. Louis in home runs and will look to challenge Skubal’s elite pitching.

Tigers’ Power vs. Cardinals’ Defense

  • Detroit is 11-4 in games when they hit two or more home runs.
  • St. Louis must limit extra-base hits to stay competitive.

Game Outlook

The Tigers enter as slight favorites, given their strong pitching matchup and Skubal’s dominance. However, St. Louis’ home-field advantage and recent momentum could make this a close contest.

If Detroit’s offense rebounds and Skubal controls the game, they should secure a victory. However, if St. Louis’ lineup finds early success, they could pull off another win.

Game Odds

Detroit Tigers                    – 192

St. Louis Cardinals           7.5

Odds Courtesy of Sports Odds Direct as of Monday, May 19, 2025

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