MLB Game Preview: Cincinnati Reds (20-12) vs. Pittsburgh Pirates (17-16)

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Pittsburgh Pirates logo

Venue: PNC Park — Pittsburgh, Pennsylvania

First Pitch: 6:40 PM ET

Broadcast: Bally Sports Ohio / SportsNet Pittsburgh / MLB.tv

WEATHER REPORT — PITTSBURGH

Temperature: 63–66°F at first pitch

Wind: 6–9 mph blowing out to right‑center

Sky: Mostly clear

Impact: Slight boost for left‑handed power hitters; neutral for pitchers

INJURY REPORT

Cincinnati Reds

Hunter Greene — day‑to‑day (shoulder fatigue)

Matt McLain — IL (oblique)

TJ Friedl — IL (wrist)

Nick Lodolo — IL (forearm)

Brandon Williamson — IL (shoulder)

Cincinnati’s rotation depth is stretched, but the lineup remains strong.

Pittsburgh Pirates

Oneil Cruz — day‑to‑day (hamstring tightness)

Ke’Bryan Hayes — IL (back)

Marco Gonzales — IL (forearm)

Luis Ortiz — IL (elbow)

Pittsburgh’s infield is thin without Hayes, but the outfield and bullpen are healthy.

PROBABLE PITCHING MATCHUP

Cincinnati — RHP Graham Ashcraft (3–1, 3.86 ERA, 1.24 WHIP)

Ashcraft has been solid, mixing cutter/sinker combos effectively. Road ERA is slightly higher, but he’s limiting hard contact.

Pittsburgh — RHP Mitch Keller (2–2, 4.12 ERA, 1.31 WHIP)

Keller remains inconsistent but flashes ace‑level outings. His strikeout rate is up, but command lapses lead to big innings.

Pitching Edge: Slight to Cincinnati (Ashcraft more consistent).

TEAM RECORDS & RECENT FORM

Cincinnati Reds (20–12)

Last 10: 7–3

Road record: 9–6

Runs per game last 10: 5.2

Team ERA last 10: 3.91

Cincinnati is one of the hottest teams in the NL, powered by a deep lineup and improved bullpen.

Pittsburgh Pirates (17–16)

Last 10: 5–5

Home record: 8–7

Runs per game last 10: 4.3

Team ERA last 10: 4.47

Pittsburgh is hovering around .500, competitive but inconsistent.

KEY PLAYER MATCHUPS

1. Elly De La Cruz (CIN) vs. Mitch Keller

De La Cruz is hitting .298 with 5 HR and 9 SB over his last 12 games.

Keller struggles vs. high‑velocity fastball hitters. Micro‑edge: De La Cruz

2. Spencer Steer (CIN) vs. Pirates Bullpen

Steer leads the Reds in RBI and thrives in late‑inning situations.

Pirates bullpen has a 4.21 ERA in the last 10 games. Micro‑edge: Steer

3. Bryan Reynolds (PIT) vs. Graham Ashcraft

Reynolds is hitting .333 with 3 HR in his last 10.

Ashcraft’s cutter can be vulnerable to switch‑hitters. Micro‑edge: Reynolds

4. Oneil Cruz (PIT) vs. Reds Left‑Side Defense

If active, Cruz’s power/speed combo is a major threat.

Reds’ 3B/SS defense has been average without McLain. Micro‑edge: Cruz (if he plays)

SERIES HISTORY

2025–26 Season Series: Reds lead 1–0 (CIN won 5–2 on May 1)

Last 10 meetings: Reds lead 6–4

At PNC Park: Reds 4–3 in last 7

Cincinnati has quietly controlled this matchup recently.

BETTING TRENDS

Cincinnati Reds

7–3 last 10

5–1 in last 6 road games

Over is 6–4 in last 10

4–1 in last 5 vs. NL Central

Pittsburgh Pirates

5–5 last 10

3–4 in last 7 home games

Under is 6–3–1 in last 10

2–5 in last 7 vs. NL Central

Game Odds

Cincinnati Reds                 8

Pittsburgh Pirates            – 141

Odds Courtesy of Sports Odds Direct as of Friday, May 1, 2026