NFL Game Preview: San Francisco 49ers (5-3) vs. New York Giants (2-6)

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Venue & Game Details

Venue: MetLife Stadium, One MetLife Stadium Drive, East Rutherford, NJ 07073

Capacity: ~82,500

Kickoff: 1:00 PM ET (10:00 AM PT)

Broadcast: CBS: Kevin Harlan, Trent Green, Melanie Collins (field reporter)

Weather Forecast (East Rutherford, NJ – Nov. 2, 2025)

Temperature: ~54°F at kickoff, cooling into the upper 40s by the 4th quarter

Conditions: Partly cloudy, light winds (6–8 mph)

Impact: Mild fall conditions; no major weather impact expected

Injury Report

San Francisco 49ers:

QB Brock Purdy (toe) – questionable, chance to return

WR Brandon Aiyuk (knee, PUP list) – out

DE Bryce Huff (hamstring) – questionable

LB Dee Winters (knee) – questionable

New York Giants:

RB Cam Skattebo (ankle) – out for season

CB Paulson Adebo (knee) – out

S Jevon Holland (knee) – questionable

DE Chauncey Golston (neck) – questionable

Key Player Matchups

Christian McCaffrey (SF) vs. Giants Run Defense: McCaffrey leads SF with 490 rushing yards and 559 receiving yards, and faces a Giants defense allowing 148.9 rush YPG.

Jaxson Dart (NYG) vs. 49ers Secondary: Dart has 984 passing yards, 8 TDs, 3 INTs, but faces a defense allowing 229.3 pass YPG.

Brian Burns (NYG) vs. 49ers O-Line: Burns leads the Giants with 10 sacks, a critical factor against a shaky SF pass protection.

Team Form

San Francisco 49ers:

Last 5: Lost to Texans 26-15, Beat Falcons 20-10, Lost to Buccaneers 30-19, Beat Rams 26-23 (OT), Lost to Jaguars 26-21

Offense: 20.0 PPG, 259.3 pass YPG, 89.4 rush YPG

Defense: 20.5 PPG allowed, 337.1 YPG allowed

New York Giants:

Last 5: Lost to Eagles 38-20, Lost to Broncos 33-32, Beat Eagles 34-17, Lost to Saints 26-14, Beat Chargers 21-18

Offense: 21.6 PPG, 207.3 pass YPG, 118.0 rush YPG

Defense: 26.9 PPG allowed, 382.4 YPG allowed

Series History

All-Time: 49ers lead 23–21

Last Meeting (2023): 49ers won 30-12 in Santa Clara

At MetLife Stadium: Giants lead 11–9

Betting Trends

San Francisco: 4-4 ATS this season; 2-2 ATS on the road

New York: 2-6 ATS overall; 2-1 ATS at home

Totals: Over has hit in 5 of SF’s 8 games; Over in 5 of NYG’s 8

Head-to-Head: 49ers have covered in 3 of last 4 vs. Giants

Historical Betting Results

49ers are 6-2 ATS in last 8 NFC road games

Giants are 1-4 ATS in last 5 vs. NFC West

The Over has hit in 4 of last 6 head-to-head matchups

Projected Score: 49ers 27, Giants 20

49ERS NOTES:

• QB BROCK PURDY has 2+ TD passes in each of his past 4 starts. Has 36 TDs (35 pass, 1 rush) & 109.1 rating in 18 career road starts. Passed for 310 yards & 2 TDs in only career start vs. NYG. • QB MAC JONES passed for 193 yards & 2 TDs in Week 8. Ranks 2nd in NFC with 266.2 pass yards per game this season. Has 2+ TD passes in 3 of his 4 road starts in 2025. • RB CHRISTIAN MCCAFFREY had 3 catches and 68 scrimmage yards (43 rec., 25 rush) last week. Is 5th player ever with 5,000+ rush yards & 5,000 rec. yards. Ranks 2nd in NFL in scrimmage yards (1,049) & receptions (56) in 2025. Has 110+ scrimmage yards & TD in 4 of his past 5 games. Has 47 career games with 50+ rec. yards, tied 3rd-most by RB in SB era. Has 14 catches, 340 scrimmage yards (113.3 per game) & 2 TDs in 3 career games vs. NYG. • WR JAUAN JENNINGS led team with 45 rec. yards in Week 8. Had 31 rec. yards in last meeting. • WR KENDRICK BOURNE had 44 rec. yards last week. Has 5+ catches & 140+ rec. yards in 2 of his past 3 on road. • TE GEORGE KITTLE had 43 rec. yards & TD catch in Week 8. Needs 4 catches for reach 550 & 52 rec. yards to reach 7,500 for his career. Has TD catch in his past 2 on road. • DT ALFRED COLLINS leads rookies with 2 FR in 2025. • DE MYKEL WILLIAMS (rookie) had 1st-career FR last week. • LB TATUM BETHUNE led team with career-high 14 tackles in Week 8. Aims for his 4th in row with 10+ tackles. • LB DEE WINTERS had career-high 11 tackles last week. • S MALIK MUSTAPHA tied career-high 12 tackles & had 1st TFL on season in Week 8. • S MARQUES SIGLE tied-1st among NFC rookies in tackles (45) in 2025. • CB DEOMMODORE LENOIR has PD in 3 of his past 4.

GIANTS NOTES:

• QB JAXSON DART passed for 193 yards & TD in Week 8. Leads rookies in TD passes (8) & passer rating (90.8) in 2025. Can become 1st QB since 2023 (Jake Browning) to have TD pass in each of 1st 6 career starts. Has 65+ comp. pct., TD pass & rush TD in both career home starts. • RB DEVIN SINGLETARY had 83 scrimmage yards (61 rush, 22 rec.) in only career game vs. SF (12/7/20 w/ Buf.). • RB TYRONE TRACY led team with season-high 53 scrimmage yards (39 rush, 14 rec.) in Week 8. • WR WAN’DALE ROBINSON led team with 48 rec. yards last week. Has 5+ catches in 3 of his past 4. • LB BRIAN BURNS has sack in 7 of his past 8, incl. sack in Week 8. Has TFL in 8 straight, longest active streak. Had sack & PD in his last game vs. SF (10/9/22 w. Car.). • LB BOBBY OKEREKE led team with 8 tackles & had 1st sack of season last week. Has 6+ tackles in 7 of 8 games this season. Had 9 tackles in last meeting. • LB KAYVON THIBODEAUX had 5 tackles & PD in Week 8. Has TFL in 3 of his past 4 at home. Had sack in last meeting. • LB ABDUL CARTER had career-high 5 tackles last week. • DT DEXTER LAWRENCE had half sack in Week 8. Had 7 tackles in last meeting. • DT RAKEEM NUNEZ-ROCHES had 1st sack of season last week. • DT DARIUS ALEXANDER (rookie) had half sack in Week 8. • CB ANDRU PHILLIPS had PD last week. Has TFL in 2 of his past 3. • S TYLER NUBIN had 5 tackles, TFL & 1st PD of season in Week 8. Has 5+ tackles in 3 of past 4. • S DANE BELTON had 7 tackles last week & aims for his 4th in row with 5+ tackles.

Game Odds

San Francisco 49ers                        – 2.5

New York Giants                              48.5

Odds Courtesy of Sports Odd Direct as of Saturday, November 1, 2025