FOX: Kevin Burkhardt, Tom Brady, Erin Andrews (field reporter), Tom Rinaldi (field reporter)
Kickoff is scheduled for 4:25 PM ET
Lumen Field
Referee: Land Clark
Regular Season: SEA leads series, 31-23 (away team won past 4)
Last reg. season meeting: 1/3/26: SEA 13 at SF 3
Kyle Shanahan (SF) vs. Opp. (incl. postseason): 9-11 Reg. Season: 86-67 (.562)
Mike Macdonald (SEA) vs. Opp. (incl. postseason): 3-2 Reg. Season: 27-11 (.711)
San Francisco Last Game: W, 24-14 vs. DEN (Week 4)
Seattle Last Game: W, 30-23 vs. LAC (Week 4)
49ERS NOTES
• 49ERS are 4-0 for 4th time since 1990 (1990, 2019 & 2023). • QB BROCK PURDY completed 19 of 30 pass atts. (63.3 pct.) for 218 yards & 2 TDs for 107.4 rating in Week 4. Aims for 5th in row with 2+ TD passes. Is only QB with 2+ TD passes & 100+ rating in each of 1st 4 weeks. Had TD pass in 6 of his past 7 vs. Sea. • RB CHRISTIAN MCCAFFREY had 70 scrimmage yards (52 rush, 18 rec.) & rush TD in Week 4. Is 4th player ever (Warrick Dunn & HOFers Eric Dickerson & Marshall Faulk) with 6,000+ scrimmage yards with 2 teams (7,272 w/ Car.) (6,047 w/ SF). Has 100+ scrimmage yards in 7 of his past 8 vs. Sea. Ranks 2nd with 13,319 scrimmage yards (7,807 rush, 5,512 rec.) & 3rd with 102 scrimmage TDs (66 rush, 36 rec.) since 2017. • WR MIKE EVANS led team with 5 receptions for 76 yards in Week 4. Has 110 career TD catches & needs 1 TD catch to tie HOF Tony Gonzalez (111) for 9th most in NFL history. • WR DEEBO SAMUEL had TD reception in Week 4 & has TD catch in 3 of his past 4. Had 102 rec. yards & TD catch in last game at Sea. (10/10/24). • TE GEORGE KITTLE had 4 catches for 70 yards & TD in Week 4. Aims for 4th in row with TD reception. Has TD catch in 3 of his past 4 vs. Sea. • LB DRE GREENLAW led team with 12 tackles & had FF in Week 4. Aims for 4th in row with 8+ tackles. Has 8+ tackles in 6 of his past 7 vs. Sea. • LB FRED WARNER had 7 tackles & 2 PD in Week 4. Ranks tied-5th with 40 tackles this season. Has 8+ tackles in 3 of his past 4 vs. Sea. • CB UPTON STOUT had 6 tackles in Week 6. Has 5+ tackles in 2 of his past 3. • CB RENARDO GREEN had 2 PD in last road meeting. Only CB in NFL this season with 13+ tackles in a single game. • S MALIK MUSTAPHA had PD in Week 4. Had INT in last game at Sea. (10/10/24). Has 7+ tackles in 2 of his past 3 on road.
SEAHAWKS NOTES
• QB SAM DARNOLD had 2 TD passes & 94.5 rating in Week 4. Aims for 3rd in row with TD pass. In 2025, became 4th QB ever to win Super Bowl in 1st season with team, joining Tom Brady, Trent Dilfer & Matthew Stafford. • RB EMANUEL WILSON had 120 scrimmage yards (81 rush, 39 rec) & 2 TDs (1 rush, 1 rec.) in Week 4. Has 90+ scrimmage yards in 2 of his past 3. • WR RASHID SHAHEED had rush TD in Week 4. • WR JAXON SMITH-NJIGBA led team with 5 receptions for 76 yards in Week 4. Leads NFL with 6 TD receptions & ranks 3rd with 481 rec. yards in 2026. Has 120+ rec. yards & TD catch in 3 of his past 4. Ranks 5th with 4,032 rec. yards since 2023. Aims for 4th in row with 80+ rec yards & 5th in row with 5+ receptions vs. SF. Had rec. TD in 2025 NFC-D vs. SF. • LB ERNEST JONES IV led team with 12 tackles & had sack, TFL, INT & PD in Week 4, his 4th consecutive game with 8+ tackles, tied-longest active streak in NFL this season (Alex Singleton, Anthony Hill & Jihaad Campbell). Aims for 3rd in row with PD. Aims for 8th in row with 5+ tackles vs. SF. Had INT in Week 1 meeting last season. Had INT & FF in 2025 NFC-D vs. SF. • LB DRAKE THOMAS had 5 tackles, TFL, INT & PD in Week 4. Aims for 5th in row with 5+ tackles & TFL. Aims for 3rd in row at home with TFL. Had 5 tackles, 2 PD & INT in last meeting. • LB DEMARCUS LAWRENCE had 2 TFL in Week 4. Aims for 3rd in row with TFL. Had 6 tackles & 2 TFL in Week 1 meeting last season. Had sack & 2 FFs in 2025 NFC-D vs. SF. • CB DEVON WITHERSPOON had 9 tackles & TFL in Week 4. Aims for 4th in row with 6+ tackles. Has TFL in 2 of his past 3. Has 5+ tackles in 3 of his past 4 vs. SF. • S NICK EMMANWORI had 9 tackles, 2 TFL, sack & PD in Week 4. Had 7 tackles & TFL in last meeting & aims for 3rd in row vs. SF with TFL. • S JULIAN LOVE totaled 5 tackles & PD in Week 4.
Game Odds
San Francisco 49ers 46
Seattle Seahawks – 3
Odds Courtesy of Sports Odd Direct as of Saturday, October 10, 2026
