MLB Game Preview: St. Louis Cardinals (28-21) vs. Cincinnati Reds (26-24) Double-Header

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Cincinnati Reds logo

Game 1 First Pitch: 12:10 PM ET

Game 2 First Pitch: Approximately 6:40 PM ET (or 45 minutes after Game 1 ends)

Broadcast: Bally Sports Ohio / Bally Sports Midwest

WEATHER OUTLOOK — GREAT AMERICAN BALL PARK

  • Temperature: 77–82°F across the day
  • Wind: 8–12 mph out to right-center
  • Humidity: 60–65%
  • Rain: <10% (dry day expected)
  • Impact:
    • GABP is already one of MLB’s top HR parks
    • Warm temps + wind out = significant boost to left-handed power
    • Expect elevated run-scoring conditions in both games

INJURY REPORT

St. Louis Cardinals

  • Nolan Arenado — Probable (minor back tightness)
  • Willson Contreras — OUT (forearm fracture; IL)
  • Tommy Edman — OUT (wrist surgery; IL)
  • Steven Matz — OUT (shoulder strain; IL)

Cincinnati Reds

  • Matt McLain — OUT (shoulder surgery; season-ending)
  • TJ Friedl — OUT (hamstring strain; IL)
  • Nick Lodolo — Probable (fatigue; expected to pitch in upcoming series, not today)
  • Brandon Williamson — OUT (lat strain; IL)

PROBABLE PITCHING MATCHUPS

GAME 1 — 12:10 PM ET

St. Louis: RHP Kyle Leahy

  • 2026 Stats: 2–2, 4.41 ERA, 1.33 WHIP
  • Profile:
    • Fastball 94–96 mph, decent ride
    • Slider is his out pitch
    • Fly-ball tendencies are dangerous in Cincinnati
  • Weakness:
    • Struggles vs. left-handed hitters (.286 BAA)
    • High HR/FB rate (14%)

Cincinnati: RHP Chris Paddack

  • 2026 Stats: 3–3, 3.98 ERA, 1.25 WHIP
  • Profile:
    • Changeup-heavy righty
    • Excellent command; low walk rate
    • Keeps ball down better than earlier in his career
  • Matchup Advantage:
    • Cardinals struggle vs. elite changeups
    • Paddack has been strong at home (3.21 ERA)

GAME 2 — 6:40 PM ET (Projected)

St. Louis: RHP Tink Hence (expected)

  • 2026 Stats: 1–1, 3.72 ERA, 1.18 WHIP
  • Profile:
    • Electric young arm
    • Fastball 96–98 mph, sharp curve
    • High strikeout upside
  • Concern:
    • First career start at GABP — tough environment
    • Reds hit velocity well

Cincinnati: RHP Chase Petty

  • 2026 Stats: 2–2, 4.09 ERA, 1.29 WHIP
  • Profile:
    • Heavy sinker (97 mph)
    • Generates ground balls
    • Still developing secondary pitches
  • Matchup Advantage:
    • Cardinals right-handed core (Goldschmidt, Arenado) hits sinkers well
    • Vulnerable to lefty bats

TEAM RECORDS & RECENT FORM

St. Louis Cardinals (28–21)

  • Last 10: 7–3
  • Road Record: 13–11
  • Run Differential: +19
  • Trend: Pitching stabilizing; offense improving after slow April
  • Strength: Top-5 in MLB in hard-hit rate over last 15 games
  • Weakness: Bullpen depth tested in doubleheaders

Cincinnati Reds (26–24)

  • Last 10: 5–5
  • Home Record: 14–12
  • Run Differential: +6
  • Trend: Offense streaky; pitching inconsistent
  • Strength: Athletic lineup; aggressive baserunning
  • Weakness: Missing key bats (McLain, Friedl)

KEY PLAYER MATCHUPS

Cardinals Hitters vs. Reds Pitching

  • Paul Goldschmidt: .310 career vs sinkers; strong matchup vs Petty
  • Nolan Arenado: Heating up (.333 last 7 games)
  • Lars Nootbaar: Best matchup vs Paddack’s fastball/changeup combo
  • Masyn Winn: Elite contact; thrives vs command pitchers

Reds Hitters vs. Cardinals Pitching

  • Elly De La Cruz: HR/SB threat; Leahy’s fly-ball profile is dangerous
  • Spencer Steer: .295 at home; excellent vs sliders
  • Christian Encarnacion-Strand: Power bat boosted by weather
  • Jeimer Candelario: Switch-hitter with strong OBP

SERIES HISTORY

  • 2024–2026: Cardinals lead 17–14
  • At GABP: Reds have won 5 of last 8
  • Cardinals swept a doubleheader here in 2023, Reds swept one in 2025

BETTING TRENDS

St. Louis

  • 6–2 in last 8 road games
  • 5–1 in last 6 vs NL Central
  • Over is 4–1 in last 5

Cincinnati

  • 4–1 in last 5 home games
  • 6–2 in last 8 as underdog
  • Over is 7–3 in last 10 at GABP

GAME 1 ODDS

St. Louis Cardinals           9.5

Cincinnati Reds                 – 109

GAME 2 ODDS

St. Louis Cardinals           – 106

Cincinnati Reds                 9.5

Odds Courtesy of Sports Odds Direct as of Friday, May 22, 2026