Venue & Timing
Location: State Farm Stadium, One Cardinals Drive, Glendale, AZ 85305
Kickoff: 1:05 PM ET (10:05 AM PST)
Broadcast: FOX: Kevin Kugler, Daryl Johnston, Allison Williams (field reporter)
Weather Update
Forecast: Clear skies, 67°F, light winds at 5 mph
Impact: Ideal conditions for passing and kicking; no weather disruptions expected.
Injury Report
San Francisco 49ers:
QB Mac Jones — healthy, expected starter
RB Christian McCaffrey — probable (minor ankle soreness, limited vs. Rams)
WR Kendrick Bourne — healthy, coming off 319-yard passing game from Jones
Arizona Cardinals:
QB Kyler Murray — healthy, starting despite recent struggles
WR Marquise Brown — questionable (hamstring)
RB James Conner — probable (shoulder)
Player Matchups
Mac Jones (SF QB) vs. Kyler Murray (ARI QB)
Jones: 319 yards, 3 TDs vs. Rams, but padded stats in garbage time.
Murray: inconsistent, averaging 215 passing yards/game, needs bounce-back.
Christian McCaffrey (SF RB) vs. Cardinals Run Defense
McCaffrey held to 30 yards on 12 carries vs. Rams, but remains SF’s offensive engine.
Cardinals allow 126 rushing yards/game, bottom-10 in NFL.
Deebo Samuel (SF WR) vs. Marquise Brown (ARI WR)
Samuel: versatile weapon, averaging 72 scrimmage yards/game.
Brown: questionable, but key deep threat if active.
Team Recent Form
San Francisco 49ers:
Lost last game vs. Rams (42–26).
Won 3 of last 5 games, but defense leaking points (23.0 PPG allowed).
Offense averaging 22.0 PPG, ranked 15th in NFL.
Arizona Cardinals:
Lost last game vs. Seahawks (44–22).
1-4 in last five games, defense allowing 339.4 yards/game.
Offense averaging 20.1 PPG, ranked 23rd in NFL.
Series History
49ers lead all-time series 36–29.
San Francisco has won 4 of last 5 meetings.
Cardinals last beat 49ers at home in 2021.
Betting Trends
49ers: 3-2 ATS in last five games, but defense vulnerable.
Cardinals: 1-4 ATS in last five, struggling to cover spreads.
Over has hit in 4 of last 5 49ers games, Cardinals trending Over after defensive collapses.
Score Projection: 49ers 30 – Cardinals 24
Summary: The 49ers enter as slight favorites despite defensive struggles, with Mac Jones and Christian McCaffrey expected to lead the offense. The Cardinals, led by Kyler Murray, must improve defensively to stay competitive.
49ERS NOTES:
• QB MAC JONES completed 33 of 39 pass att. (season-high 84.6%) for 319 yards, 2 TDs & INT for 115.7 rating, his 5th game this season with 250+ pass yards & multiple TD passes. Aims for 3rd consecutive road game with multiple pass TDs. • QB BROCK PURDY has 250+ pass yards & 2+ pass TDs in both starts in 2025. • RB CHRISTIAN MCCAFFREY had 96 scrimmage yards (66 receiving, 30 rushing) last week. Has 626 rushing yards & 692 receiving yards this season, 3rd player in NFL history (HOFer Marshall Faulk & Brian Westbrook) with 600+ rec. & 600+ rush in 4 career seasons. Has 7, 013 rush yards & 5,158 rec. yards in his career – 4th player in NFL history (HOFers Marcus Allen, Marshall Faulk & Tiki Barber) with 7,000+ rush yards & 5,000+ rec. yards. Has 100+ scrimmage yards in 5 of his last 6 on road. • RB BRIAN ROBINSON had team-high 8 carries for 41 yards & TD last week. Aims for 3rd straight with rush TD. • TE GEORGE KITTLE had team-high 9 rec. for 84 yards & TD in Week 10. Has 7,564 career rec. yards, 1 of 6 TEs with 7,500+ rec. yards in 1st 9 seasons. Has rec. TD in 2 of his past 3. • WR JAUAN JENNINGS had 6 rec. for 71 yards & his 3rd rec. TD of season last week. Aims for 4th in row with 4+ rec. & 40+ rec. yards. • TE LUKE FARRELL had 2nd TD rec. of season last week. • LB TATUM BETHUNE had team-high 10 tackles & TFL last week. Aims for 6th in row with 10+ tackles. • LB DEE WINTERS had 8 tackles & TFL in Week 10. Has 5+ tackles in 2 of last 3. Aims for 3rd in row with 6+ tackles against AZ. • CB RENARDO GREEN aims for 3rd in row with 5+ tackles & PD. • S MALIK MUSTAPHA aims for his 5th in row with 5+ tackles. • S JI’AYIR BROWN has 5+ tackles in 3 of last 4. Aims for 3rd in row with PD.
CARDINALS NOTES:
• QB JACOBY BRISSETT passed for 258 yards, 2 TDs & 0 INTs, adding 31 rush yards last week. Has 250+ pass yards & multiple pass TDs in all 4 starts this season. Has 110+ passer rating in 2 of his last 3. • RB EMARI DEMERCADO had 104 scrimmage yards (64 rush, 40 rec.) last week, including 55-yard rush. Has 75+ scrimmage yards in 3 of his last 4. • TE TREY MCBRIDE had team-high 9 rec. for 127 yards & TD in Week 10. Tied Travis Kelce (11 in 2020-21) for 3rd longest streak of games with 5+ rec. by a TE in NFL history (11). 1st TE in NFL history with 5+ rec. in each of his first 9 games of a season. Aims for 3rd in row vs. SF with rec. TD. • WR MARVIN HARRISON JR. aims for 3rd straight with rec. TD. Has 50+ rec. yards in last 3 at home. • LB CODY SIMON (rookie) tied for team-high 6 tackles & PD last week. • LB JOSH SWEAT had sack, 10th career FF & 1st career FR last week. Aims for 3rd in row with sack. Tied for 5th in NFL in sacks this season (8). Had sack in last meeting. Only player in NFL this season with 3 FFs, FR & 8 sacks. Aims for 5th in row with TFL at home. • DE CALAIS CAMPBELL had 5 tackles & TFL last week. Aims for 3rd straight with TFL. 1 of 4 since 1982 (HOFers Julius Peppers, Bruce Smith & Reggie White) with 5+ sacks in 15+ career seasons (15). • CB DENZEL BURKE aims for 3rd consecutive game with INT, 1 of 5 players (Jessie Bates, Emmanuel Forbes, Malaki Starks, Maxwell Hairston) in NFL this season with active steak of INT in back-to-back weeks. Has 5+ tackles in last 2 games. • CB GARRETT WILLIAMS tied for team-high 6 tackles. Aims for 3rd in row with 5+ tackles vs. SF. • S BUDDA BAKER had 5 tackles in Week 10. Has 27 straight games with 5+ • tackles, 3rd-longest active streak in NFL.
Game Odds
San Francisco 49ers – 3.5
Arizona Cardinals 48.5
Odds Courtesy of Sports Odd Direct as of Saturday, November 15, 2025
