Venue & Game Details
Stadium: NRG Stadium, Houston, Texas
Kickoff: 1:00 p.m. ET (12:00 p.m. local)
Broadcast: FOX: Kevin Kugler, Daryl Johnston, Allison Williams (field reporter)
Conference Matchup: NFC West (49ers) vs. AFC South (Texans)
Weather Forecast
Conditions: Retractable roof stadium – no weather impact expected
Outside Houston: 76°F, partly sunny
Injury Report
San Francisco 49ers:
QB Brock Purdy (toe) – Questionable, limited in practice
WR Ricky Pearsall (knee) – Questionable
DE Yetur Gross-Matos (knee/hamstring) – Questionable
C Jake Brendel (hamstring) – Questionable
CB Deommodore Lenoir (quad) – Questionable
Houston Texans:
WR Nico Collins (concussion) – Questionable
WR Christian Kirk (hamstring) – Questionable
CB Jaylin Smith (hamstring, IR) – Out
WR Justin Watson (Achilles, IR) – Out
Key Player Matchups
Christian McCaffrey (SF RB) – Leads NFL in scrimmage yards (981) and receptions (53). Faces Texans’ run defense allowing 95.2 YPG.
C.J. Stroud (HOU QB) – 1,305 yards, 9 TD, 4 INT; must handle 49ers’ disguised coverages.
Ja’Marr Chase equivalent? (Texans WR Nico Collins if healthy) – 339 yards, 3 TD; Texans need him to stretch field.
George Kittle (SF TE) – Needs 95 yards to reach 7,500 career receiving yards; could exploit Texans’ linebackers.
Will Anderson Jr. (HOU DE) vs. SF O-line – With Nick Bosa on IR, Houston’s pass rush may have the edge.
Recent Team Forms
49ers: Beat Falcons 20-10 in Week 7; defense allowing just 19.7 PPG.
Texans: Lost 27-19 to Seahawks; offense sputtering, averaging 21.2 PPG.
Series History
All-time: 49ers lead 4-1
Last Meeting: 49ers 23, Texans 7 (Jan. 2, 2022)
Largest Win: 49ers 34-3 (2013)
Texans’ Only Win: 24-21 (2009)
Betting Trends:
49ers: 4-3 ATS, 4-3 O/U
Texans: 2-4 ATS, 2-4 O/U
49ers are 3-1 ATS on the road in 2025
Texans are 0-5 ATS in last 5 vs. NFC West
Historical Betting Results
2022: 49ers -13.5, won 23-7 (Under 44)
2017: 49ers +1.5, won 26-16 (Under 45.5)
2013: 49ers -4, won 34-3 (Under 43)
2009: Texans -3, won 24-21 (Over 44.5)
2006: 49ers -1.5, won 20-17 OT (Over 35.5)
Projected Score: 49ers 20, Texans 16
49ERS NOTES:
• QB BROCK PURDY has 2+ TD passes in each of his past 4 starts. Has 36 TDs (35 pass, 1 rush) & 109.1 rating in 18 career road starts. • QB MAC JONES leads NFL with 280.8 pass yards per game (min. 5 starts) in 2025. Has 275+ pass yards in each of his 3 road starts this season & aims for his 3rd in row on road with 340+ pass yards. Had 2 TDs vs. 0 INTs for 105.6 rating in his last game vs. Hou. (12/1/24 w/ Jax.). • RB CHRISTIAN MCCAFFREY had 7 catches, 201 scrimmage yards (129 rush, 72 rec.) & 2 rush TDs in Week 7, his 4th-career game with 200+ scrimmage yards. Leads NFL in scrimmage yards (981) & ranks 3rd in receptions (53) in 2025. Is 5th RB ever with 50+ catches & 500+ rec. yards in 6 career seasons. Can record 3rd-career streak of 5+ catches in 8 straight games. Can join Herschel Walker as only RBs ever with 50+ rec. yards in 8 straight games. Has 47 career games with 50+ rec. yards, tied 3rd-most by RB in SB era. Aims for his 8th in row with 100+ scrimmage yards. • TE GEORGE KITTLE needs 8 catches for reach 550 & 95 rec. yards to reach 7,500 for his career. • WR KENDRICK BOURNE has 5+ catches & 140+ rec. yards in each of his past 2 on road. • LB TATUM BETHUNE led team with 10 tackles & had 1st-career TFL last week. Aims for his 3rd in row with 10+ tackles. • LB DEE WINTERS had 4th TFL of season last week. • DL SAM OKUAYINONU had 1st sack of season in Week 7. • DL ALFRED COLLINS (rookie) had 2nd-career FR last week. • CB DEOMMODORE LENOIR has PD in 2 of his past 3. • CB RENARDO GREEN aims for his 11th in row on road with PD. • S MALIK MUSTAPHA had 6 tackles last week. • S JI’AYIR BROWN had season-high 5 tackles in Week 7.
TEXANS NOTES:
• QB C.J. STROUD has 3 TDs vs. 0 INTs for 112.7 rating in 2 home starts in 2025 & aims for his 3rd in row at home with 95+ rating. Has TD pass in 18 of his 1st 19 career home starts. • RB NICK CHUBB has 60+ scrimmage yards in 2 of his past 3. Aims for his 3rd in row at home in 2025 with 60+ scrimmage yards. • RB WOODY MARKS (rookie) had 2nd-career TD catch last week. • WR NICO COLLINS has 50+ rec. yards in 8 of his past 9 at home & aims for his 4th in row at home with 50+ rec. yards. Has 7 rec. TDs in his past 8 home games. Needs 6 catches to reach 250 for his career. • WR JAYLIN NOEL (rookie) had career-high 77 rec. yards in Week 7. • TE DALTON SCHULTZ led team with season highs in receptions (9) & rec. yards (98). Aims for his 5th in row with 5+ catches. Had TD catch in his only career game vs. SF (12/20/20 w/ Dal.). • DE WILL ANDERSON had 4th sack of season, FF & 1st-career FR-TD last week. Has 33 TFL in 35 career games. Has 5.5 sacks in his past 6 at home. • DE DANIELLE HUNTER has 2 sacks in both home games this season & has 12 sacks & 15 TFL in 10 home games with Hou. since 2024. Aims for his 3rd in row vs. SF with sack. • DE DENICO AUTRY had sack in season debut last week. • LB AZEEZ AL-SHAAIR aims for his 4th in row with PD. Has 191 tackles, 11 TFL & 8 PD in 56 games (2019-22) with SF. • CB DEREK STINGLEY JR. had INT last week. Has INT in 2 of his past 3 & PD in 4 of his past 5. Has 22 PD & 9 INTs in 20 career home games. • CB KAMARI LASSITER set career highs with 10 tackles & 3 TFL last week. Aims for his 4th in row with PD. • S JALEN PITRE had season-high 9 tackles last week. • S CALEN BULLOCK had 1st INT of season in Week 7.
Game Odds
San Francisco 49ers 41.5
Houston Texans – 1.5
Odds Courtesy of Sports Odd Direct as of Saturday, October 25, 2025
