Melbourne Cricket Ground | Referee: Alex Kemp
Kickoff is scheduled for 8:35 PM ET | 10:35 AM AET (Friday
NETFLIX: Noah Eagle, Luke Kuechly, MJ Acosta (field reporter), Tom Pelissero (field reporter)
Westwood One: Ryan Radtke, Isaac Bruce
Regular Season: SF leads series, 78-71-3 (LAR won 4 of past 5)
Last meeting: 11/9/25: LAR 42 at SF 26
Kyle Shanahan (SF) vs. Opp. (incl. postseason): 11-8 Reg. Season: 82-67 (.550)
Sean McVay (LAR) vs. Opp. (incl. postseason): 8-11 Reg. Season: 92-57 (.617)
49ERS NOTES
• 49ers made 4th playoff appearance in past 5 years last season. • QB BROCK PURDY passed for 2,167 yards & 20 TDs in 9 games last year & totaled 147 rush yards & 3 TDs. Had TD pass in 8 of his 9 games in 2025 & threw for 295+ pass yards in 3 of his last 4 last season. • RB CHRISTIAN MCCAFFREY finished 2nd with 2,126 scrimmage yards (1,202 rush, 924 rec.) & 3rd with 17 TDs (10 rush, 7 rec.) in 2025 & became 6th player since 1990 with 2,000+ scrimmage yards in 3 career seasons. Is 1 of 2 (HOFer LaDanian Tomlinson) with 3 seasons with 2,000+ scrimmage yards & 15+ TDs. Has 95+ scrimmage yards in all 6 career games vs. LAR. & has TD in 3 of his last 4 vs. LAR. • WR MIKE EVANS ranks 1st with 13,052 rec. yards & 2nd with 108 TD catches since 2014. Has 81 games with TD catch, 10th-most all-time. Can make 1st SF debut after spending last 12 seasons with TB. Can become 6th player alltime with 10+ TD receptions in 7 career seasons. • WR DEEBO SAMUEL recorded 72 catches for 727 yards & 5 TD receptions with WAS in 2025. Had 334 receptions for 4,792 rec. yards & 22 TD catches with SF from 2019-24. • TE GEORGE KITTLE ranked tied-5th among TEs with 7 TD catches in 2025. Is 1 of 5 TEs all-time with 1,000+ rec. yards in 4 career seasons. Had 9 receptions for 84 yards & TD in last meeting. • DL NICK BOSA ranks 8th with 64.5 sacks since 2019. • LB FRED WARNER has 115+ tackles in 7 of his 8 career seasons. Aims for 3rd in row vs. LAR with 12+ tackles & has PD in 2 of his last 3 vs. LAR. • CB UPTON STOUT 1 of 2 rookies to record 80+ tackles (82) & 5+ (5) PD & FF last season. • DB DEOMMODORE LENOIR recorded 61 tackles, 4 TFL, 5 PD & 2 INT in 2025. Has PD in 2 of his last 3 vs. LAR.
RAMS NOTES
• QB MATTHEW STAFFORD named 2025 AP NFL MVP. Led NFL with 4,707 pass yards & career-high 46 TD passes in 2025, joined Tom Brady as only QBs ever with 4500+ pass yards & 40+ TD passes in 3 career seasons. Aims for 3rd in row vs. SF with 280+ pass yards & 3+ TD passes. • RB KYREN WILLIAMS ranks 6th among RBs with 3,695 rush yards since 2023. Had 13 TDs (10 rush, 3 rec.) & career-high 1,533 scrimmage yards (1,252 rush, 281 rec.) in 2025. Has 2 TDs in 4 of his 5 career games vs. SF. • WR PUKA NACUA led NFL with 129 receptions, ranked 2nd with career-high 1,715 rec. yards & tied-6th with 10 TD catches last season. Aims for 3rd in row vs. SF with TD reception. Has 115+ rec. yards in 2 of his last 3 Week 1 games. • WR DAVANTE ADAMS ranks 7th all time with 117 TD receptions. Led NFL with 14 TD catches in 2025 & became 5th player in NFL history with 10+ TD receptions in 7 career seasons. Had 6 catches for 77 yards & TD in last meeting. • DE MYLES GARRETT had 23 sacks in 2025 with Cle., most in single season since 1982. Has sack in 79 career games, tied with HOFers DeMarcus Ware & Reggie White for most games with sack in 1st 9 seasons since 1982. Named 2025 Defensive Player of the Year, 2nd career DPOY (2023). • DT AARON DONALD returns to Rams after retiring in 2024. Franchise leader in sacks (111) & TFL (176). Is 1 of 3 players to earn DPOY honors 3x (2017-18, 2020). • LB NATE LANDMAN recorded career-high 132 tackles in 2025 & ranked tied2nd with 4 FFs. Aims for 3rd in row vs. SF with 10+ tackles. • LB BYRON YOUNG had career-high 82 tackles & 12 sacks in 2025. • DE KOBIE TURNER recorded 7 sacks & 9 TFL in 2025. • CB EMMANUEL FORBES ranked tied-3rd with 18 PD last season. Had PD in 11 games in 2025. • CB TRENT MCDUFFIE had FF, 7 PD & INT in 2025 with KC. • S KAM CURL had career-high 122 tackles in 2025 & recorded 5 PD & 2 INTs.
Game Odds
San Francisco 49ers 48
Los Angeles Rams – 3.5
Odds Courtesy of Sports Odd Direct as of Wednesday, September 09, 2026
