FOX: Kevin Burkhardt, Tom Brady, Erin Andrews (field reporter), Tom Rinaldi (field reporter)
Kickoff is scheduled for 1:00PM ET
Highmark Stadium | Referee: Clete Blakeman
Regular Season: LAC leads series, 24-12-2 (BUF won past 2)
Last reg. season meeting: 12/23/23: BUF 24 at LAC 22
Jim Harbaugh (LAC) vs. Opp. (incl. postseason): 1-0 Reg. Season: 66-33-1 (.665)
Joe Brady (BUF) vs. Opp. (incl. postseason): 0-0 Reg. Season: 2-0 (1.000)
LA Chargers Last Game: L, 26-14 vs. LV (Week 2)
Buffalo Last Game: W, 41-31 vs. DET (Week 2)
CHARGERS NOTES
• QB JUSTIN HERBERT passed for 316 yards & TD in his only career game vs. Buf. (11/29/20). Aims for his 8th in row with TD pass. • RB OMARION HAMPTON had 115 scrimmage yards (94 rush, 21 rec.) & 2nd rush TD of season last week, his 3rd career game with 100+ scrimmage yards. Aims for his 3rd in row in 2026 & 5th in row overall with rush TD. Has 60+ scrimmage yards in 9 of his 11 career games. • WR QUENTIN JOHNSTON has 50+ rec. yards & rec. TD in 4 of his past 5 on road. • TE ORONDE GADSDEN had 1st TD catch of season in Week 2, his 4th career rec. TD. • LB KHALIL MACK had 1st sack of season last week, his 114th career sack. Aims for his 3rd in row in 2026 & 4th in row overall with TFL. Has TFL in 3 of his 4 career games vs. Buf. • LB TULI TUIPULOTU had 0.5 sack & FF in last meeting. Had 9 sacks & 13 TFL in 7 road games in 2025, incl. TFL in each game. • LB DAIYAN HENLEY has 5+ tackles in 7 of his past 8 on road. • LB DEL’SHAWN PHILLIPS aims for his 5th in row with 5+ tackles. • LB AHKEEM MESIDOR (rookie) had 1st career 0.5 sack last week. • LB TROY DYE had 9th-career TFL last week. • CB DONTE JACKSON had 6th career game with TFL & PD & had 4th-career FF last week. • CB CAM HART had 2 PD & 2nd-career INT last week. Aims for his 3rd in row with PD. • S DERWIN JAMES has 4 PD in his past 5 & aims for his 6th in row with 7+ tackles. Has 701 tackles, 47 PD, 12 INTs, 40 TFL & 19 sacks in 100 career games. Had 2 TFL & sack in his only career game at Buf. (9/16/18). • S TONY JEFFERSON has 2 PD, 2 TFL, sack, FF & INT in 2 career games vs. Buf.
BILLS NOTES
• QB JOSH ALLEN completed 20 of 31 atts. (64.5 pct.) for 248 yards & 3 TDs with 121.4 rating & rushed for 69 yards & 2 TDs in Week 2. Is 1st QB ever with 5 pass TDs & 4 rush TDs in 1st 2 games of season. Became 4th QB since 1950 with 90+ reg. season wins in 1st 9 seasons. Can become 4th player ever with 6+ rush TDs in each of 1st 9 seasons. Aims for his 3rd in row with 60+ comp. pct., 245+ pass yards, 2+ TD passes, 2+ rush TDs & 120+ rating. Completed 15 of 21 atts. (71.4 pct.) for 237 yards & TD with 104.7 rating & had 2 rush TDs in last meeting. • RB JAMES COOK led team with 139 scrimmage yards (135 rush, 4 rec.) & had rush TD last week. Has 75+ scrimmage yards in 5 of his past 6 at home. Rushed for 70 yards in last meeting. • WR JOSHUA PALMER aims for his 3rd in row with rec. TD. Spent 1st 4 seasons (2021-24) with LAC, totaling 182 receptions for 2,287 yards & 10 TDs. • TE DALTON KINCAID had 7 catches for 95 yards & TD in Week 2. Aims for his 4th in row, incl. playoffs, with 5+ catches & 80+ rec. yards. • TE DAWSON KNOX had rec. TD last week. Has rec. TD in 2 of his past 3. • LB BRADLEY CHUBB had 4 tackles & 1.5 sacks in Week 2. • LB GREG ROUSSEAU had 2 sacks & FF last week. Has 2+ sacks in 3 of his past 4. Aims for his 3rd in row with 2 sacks & FF. Had 6 tackles in last meeting. • LB TERREL BERNARD had 5 tackles, TFL & PD in Week 2. Has 5+ tackles in 6 of his past 7 at home. Aims for his 3rd in row with 5+ tackles & TFL. Had 7 tackles & sack in last meeting. • LB DORIAN WILLIAMS had 6 tackles, TFL & PD last week. Aims for his 4th in row with 6+ tackles & TFL. • CB CHRISTIAN BENFORD led team with 8 tackles & had 2 PD in Week 2. Has PD in 4 of his past 5, incl. playoffs. Had 7 tackles & PD in last meeting. • S COLE BISHOP had 6 tackles last week.
Game Odds
Los Angeles Chargers 50
Buffalo Bills – 7
Odds Courtesy of Sports Odd Direct as of Saturday, September 26, 2026
