Venue & Game Details
Venue: Highmark Stadium, One Bills Drive, Orchard Park, NY 14127
Capacity: ~71,600
Kickoff: 4:25 PM ET (1:25 PM PT)
Broadcast: CBS: Jim Nantz, Tony Romo, Tracy Wolfson (field reporter)
Weather Forecast (Orchard Park, NY – Nov. 2, 2025)
Temperature: ~51°F at kickoff, dropping into the 40s by the 4th quarter
Conditions: Cloudy with a chance of light rain showers, winds 10–12 mph
Impact: Could affect deep passing and kicking; favors physical run games
Injury Report
Kansas City Chiefs:
OT Josh Simmons – questionable (personal)
G Trey Smith – questionable (back)
S Nazeeh Johnson – IR (shoulder)
TE Jake Briningstool – IR (hamstring)
Buffalo Bills:
LB Matt Milano – questionable (pectoral)
DT DaQuan Jones – questionable (calf)
LB Terrel Bernard – questionable (ankle)
K Tyler Bass – IR (hip)
Key Player Matchups
Patrick Mahomes (KC) – 2,012 yards, 16 TDs, 6 INTs – faces a banged-up Bills front seven.
Josh Allen (BUF) – 1,985 yards, 17 TDs, 7 INTs – thrives at home, but must avoid turnovers against KC’s opportunistic defense.
Travis Kelce (KC) vs. Bills Linebackers: Kelce remains Mahomes’ go-to target; Buffalo’s injuries at LB could be costly.
James Cook (BUF) vs. Chiefs Run Defense: Cook’s versatility is key to keeping Allen from carrying the entire offense.
Team Form
Kansas City Chiefs:
Last 5: Beat Commanders 28-7, Beat Raiders 31-0, Beat Lions 30-17, Lost to Jaguars 31-28, Beat Ravens 37-20
Offense: 27.5 PPG, 411.8 YPG since Week 4
Defense: 17.7 PPG allowed, 174.6 pass YPG allowed (3rd NFL)
Buffalo Bills:
Last 5: Beat Panthers 40-9, Lost to Falcons 24-14, Lost to Patriots 23-20, Beat Saints 31-19, Beat Dolphins 31-21
Offense: 26.8 PPG, 374.2 YPG
Defense: 22.4 PPG allowed, 5.4 yards/play allowed (19th NFL)
Series History
All-Time: Bills lead 30–26–1
Recent: Bills have won 4 of last 5 regular-season meetings, including 30-21 in 2024
Playoffs: Chiefs are 4-0 vs. Bills since 2020, including the 2025 AFC Championship (KC 32–29)
Betting Trends
Chiefs: 5-3 ATS this season; 1-2 ATS on the road
Bills: 2-4 ATS overall; 1-3 ATS at home
Totals: Over has hit in 6 of last 8 KC-BUF meetings
Head-to-Head: Josh Allen is 4-1 vs. Mahomes in regular season, but 0-4 in playoffs
Historical Betting Results
Chiefs are 6-2 ATS in last 8 AFC games
Bills are 4-4 SU as a home underdog since 2019
The Over has cashed in 6 of last 8 head-to-head matchups
Projected Score: Chiefs 30, Bills 27
CHIEFS NOTES:
• QB PATRICK MAHOMES passed for 299 yards & 3 TDs with 104.9 rating in Week 8, his 46th-career game with 3+ TD passes, tied with HOFer Dan Marino for most by player in 1st 9 seasons all-time. Aims for his 4th in row with 3+ TD passes & 100+ rating. Ranks tied-1st with 17 TD passes in 2025. Has 2,465 pass yards (273.9 per game) & 22 TDs (19 pass, 3 rush) with 101 rating in 9 career starts vs. Buf., incl. playoffs, with TD pass in each game. • RB ISIAH PACHECO had season-high 58 rush yards last week. Had 111 scrimmage yards (97 rush, 14 rec.) & rush TD in his only career game at Buf. (1/21/24 – AFC-D). • RB KAREEM HUNT had 8th career game with rush TD & rec. TD last week. Had rush TD in 2024 AFC-C vs. Buf. • TE TRAVIS KELCE had 6 catches for season-high 99 yards & 3rd rec. TD of season in Week 8. Became 4th TE ever with 100+ career rec. TDs, incl. playoffs., & 5th TE all-time with 80+ career reg. season rec. TDs. Has 83 career TDs, tied-most in KC history. Ranks 2nd among TEs with 474 rec. yards in 2025 & can become 4th TE ever with 500+ rec. yards in 12 career seasons. • WR RASHEE RICE had 9 catches for 93 yards & 12th-career rec. TD last week. Has 5+ catches in 11 of his past 12 games. • DT CHRIS JONES has 5th-straight season with 5+ TFL. • DE GEORGE KARLAFTIS had 29th-career sack last week. Has 5.5 sacks & 8 TFL in his past 5 on road & aims for his 6th in row on road with 0.5+ sacks. • DE MIKE DANNA had 1st sack of season & 1st-career INT last week. Had sack & FF in 2024 AFC-C vs. Buf. • LB NICK BOLTON has 6+ tackles in 7 of 8 games in 2025. Has 6+ takles in each of his 7 career games vs. Buf., incl. playoffs. • LB DRUE TRANQUILL & DB CHAMARRI CONNER each had 9 tackles & FF in 2024 AFC-C vs. Buf. Conner has INT in both career reg. season games vs. Buf.
BILLS NOTES:
• QB JOSH ALLEN had 3 TDs (2 rush, 1 pass) in Week 8, his 46th-career game with both TD pass & rush TD, most all-time. Joined Cam Newton (75) as only QBs ever with 70+ reg. season rush TDs (70). Has 5 rush TDs in 2025 & can become 1st QB & 4th player ever with 6+ rush TDs in each of 1st 8 seasons. Aims for his 6th in row at home with 2+ TD passes & 100+ rating. Has 24 TDs (19 pass, 5 rush) vs. 4 INTs for 97.2 rating in 9 career starts vs. KC, incl. playoffs, with TD pass in each game. • RB JAMES COOK had career-high 216 rush yards & 6th-career game with 2 rush TDs last week. Ranks 2nd in NFL with 753 rush yards & 4th with 7 rush TDs in 2025. Had 134 scrimmage yards (85 rush, 49 rec.) & 2 rush TDs in 2024 AFC-C vs. KC. Had 2 rush TDs in last reg. season meeting. Has rush TD in 7 of his past 8 at home. • WR KHALIL SHAKIR led team with 6 catches & 88 rec. yards & had 3rd rec. TD of season last week, his 10th-career TD catch. Has 5+ catches in 3 of his past 4. Has TD catch in 2 of his past 3 at home. Aims for his 4th in row vs. KC, incl. playoffs, with 6+ catches. • DE JOEY BOSA had 75th-career sack last week. • DE GREG ROUSSEAU had sack & 7th-career FF in Week 8. Has sack in 2 of his past 3. • DE A.J. EPENESA had sack & 3rd-career INT last week. Has 0.5+ sacks in 3 of his past 4. • DE MICHAEL HOECHT had 1.5 sacks & 3rd-career FF last week. • LB MATT MILANO had 9 tackles & sack in 2024 AFC-C vs. KC. • LB DORIAN WILLIAMS aims for his 5th in row with 5+ tackles. • CB CHRISTIAN BENFORD had 3rd-career FR last week. Aims for his 3rd in row vs. KC, incl. playoffs, with PD. • S COLE BISHOP led team with season-high 7 tackles last week.
Game Odds
Kansas City Chiefs – 1.5
Buffalo Bills 52.5
Odds Courtesy of Sports Odd Direct as of Saturday, November 1, 2025
