CBS: Kevin Harlan, Trent Green, Melanie Collins (field reporter)
Kickoff is scheduled for 4:25 PM ET
Levi’s Stadium
Referee: Ron Torbert
Regular Season: DEN leads series, 8-7 (home team won past 4)
Last reg. season meeting: 9/25/22: SF 10 at DEN 11
Sean Payton (DEN) vs. Opp. (incl. postseason): 7-3 Reg. Season: 186-109 (.631)
Kyle Shanahan (SF) vs. Opp. (incl. postseason): 1-1 Reg. Season: 85-67 (.559)
Denver Last Game: W, 30-26 vs. LAR (Week 3)
San Francisco Last Game: W, 36-30 vs. ARI (Week 3)
BRONCOS NOTES
• QB BO NIX totaled 3 TDs (2 pass, 1 rush) in Week 3, his 5th-career game with 2+ TD passes & rush TD. Has TD pass in 12 of his past 13 on road. Since 2024, is 1 of 2 QBs (Josh Allen) with 50+ TD passes (58) & 10+ rush TDs (10). Is 10-1 as starting QB vs. NFC. • RB J.K. DOBBINS had season-high 53 scrimmage yards (49 rush, 4 rec.) last week. • RB RJ HARVEY led team & tied his career high with 6 catches last week. Has 4+ catches in 5 of his past 6 on road. • WR COURTLAND SUTTON had 8 catches for 97 yards in last meeting. • WR JAYLEN WADDLE ranks 4th among players drafted in 2021 in receptions (384), rec. yards (5,189) & rec. TDs (26). • WR PAT BRYANT had 2nd-career TD catch last week. • DL ZACH ALLEN had 35th-career sack last week. • DT MALCOLM ROACH aims for his 3rd in row with TFL. • LB NIK BONITTO had 1st sack of season in Week 3. • LB ALEX SINGLETON aims for his 4th in row with 8+ tackles. Ranks tied-2nd with 33 tackles in 2026. Had INT-TD in his only career game at SF (10/4/20 w/ Phi.). • LB JUSTIN STRNAD had TFL & PD last week & aims for his 3rd in row with TFL. • CB PAT SURTAIN II aims for his 3rd in row with 6+ tackles. Had 2 PD in last meeting. • CB RILEY MOSS aims for his 5th in row with PD. • S BRANDON JONES led team with 12 tackles & had 15th-career TFL last week. Aims for his 4th in row with 5+ tackles. • S TALANOA HUFANGA had 5 tackles, sack, 3 PD & 2 INTs, incl. 66-yard INT-TD, in Week 3, 1st player since 1982 with sack, 2 INTs & 50+-yard INT-TD in single quarter of single game. Had 214 tackles, 14 PD & 7 INTs in 49 games (2021-24) with SF. Aims for his 3rd in row with TFL & 4th in row with 5+ tackles.
49ERS NOTES
• 49ERS can begin 4-0 for 4th time since 1990 (1990, 2019 & 2023). • QB BROCK PURDY passed for 297 yards & 4 TDs vs. 0 INTs for 133.8 rating in Week 3, his 5th-career game with 4+ TD passes. Is only QB with 2+ TD passes & 100+ rating in each of 1st 3 weeks. Has 285+ pass yards, 2+ TD passes & 115+ rating in 4 of his past 5 home starts. • RB CHRISTIAN MCCAFFREY had 116 scrimmage yards (75 rush, 41 rec.) & 65th-career rush TD last week. Has 2,836 scrimmage yards (113.4 per game) & 25 TDs (18 rush, 7 rec.) in 25 home games with SF since 2022. Can become 4th player ever (Warrick Dunn & HOFers Eric Dickerson & Marshall Faulk) with 6,000+ scrimmage yards with 2 teams. • TE GEORGE KITTLE led team with 6 catches for 82 yards & 2 TDs in Week 3, his 9th-career game with 2+ TD catches. Aims for his 3rd in row with 80+ rec. yards & TD catch. Since 2017, ranks 2nd among TEs in receptions (607) & rec. yards (8,182) & 3rd in rec. TDs (55). Had 7 catches for career-high 210 yards & TD in last home meeting (12/9/18), 2nd-most rec. yards in single game by TE all-time. • WR MIKE EVANS had 110th-career rec. TD last week, 10th-most in NFL history. • WR DEEBO SAMUEL had 94 scrimmage yards (80 rec., 14 rush) & 29th-career rec. TD in Week 3. Aims for his 3rd in row vs. Den. with 60+ scrimmage yards. • LB FRED WARNER had career-high 17 tackles & TFL last week. Ranks tied-2nd with 33 tackles in 2026. Can appear in 125th career game in Week 4. • LB DRE GREENLAW aims for 3rd in row with 8+ tackles. • DL KEION WHITE aims for his 3rd in row with sack. • DL OGBO OKORONKO had 18th-career sack in Week 3. • CB RENARDO GREEN had career-high 13 tackles last week. Has PD in 2 of 3 games this season. • CB DEOMMODORE LENOIR had 1st PD of season in Week 3.
Game Odds
Denver Broncos 48
San Francisco 49ers – 2.5
Odds Courtesy of Sports Odd Direct as of Saturday, October 3, 2026
