Venue & Game Details
Location: Levi’s Stadium, Santa Clara, CA
Kickoff: 8:15 PM ET (5:15 PM PT local)
Broadcast: ESPN: Joe Buck, Troy Aikman, Lisa Salters (field reporter), Laura Rutledge (field reporter)
Westwood One: Ryan Radtke, Ryan Fitzpatrick
Weather Updates
Forecast: Clear skies, 58°F, light winds (5–8 mph).
Impact: Ideal football conditions; no major weather disruptions expected.
Injury Report
Carolina Panthers:
QB Bryce Young – healthy, coming off a franchise-record 448 passing yards vs. Atlanta.
WR Tetairoa McMillan – probable, 130 yards and 2 TDs last week.
WR Xavier Legette – healthy, 83 yards and 1 TD vs. Falcons.
San Francisco 49ers:
QB Brock Purdy – healthy, returned from toe injury with 200 yards and 2 TDs vs. Arizona.
RB Christian McCaffrey – healthy, league leader in touches (267), 81 rushing yards and 1 TD last week.
WR Brandon Aiyuk – out (knee).
LB Fred Warner – out (season-ending injury).
DE Nick Bosa – out (season-ending injury).
Key Player Matchups
Bryce Young (CAR QB) vs. 49ers Secondary: Young’s breakout passing game will test a defense ranked 30th in success rate due to injuries.
Christian McCaffrey (SF RB) vs. Panthers Front Seven: McCaffrey’s versatility is San Francisco’s best weapon against Carolina’s top-10 defense in success rate.
Tetairoa McMillan (CAR WR) vs. 49ers Coverage: Rookie wideout’s emergence gives Carolina a vertical threat against a vulnerable secondary.
Brock Purdy (SF QB) vs. Panthers Pass Rush: Purdy’s return stabilizes the offense, but Carolina’s defensive front will look to exploit San Francisco’s weakened protection.
Team Recent Forms
Carolina Panthers:
2nd in NFC South.
Road Record: 3–3.
Last Game: 30–27 OT win vs. Falcons.
Offense: 22.9 PPG, Defense: 20.7 PPG.
San Francisco 49ers:
2nd in NFC West.
Home Record: 4–2.
Last Game: 41–22 win vs. Cardinals.
Offense: 27.3 PPG, Defense: 24.8 PPG.
Series History
All-Time: 49ers lead 13–7.
Recent: 49ers won last meeting in 2022 (37–15).
Betting Trends
Panthers: 7–4 ATS this season; covered in 11 of last 12 as NFC underdogs.
49ers: 4–1 in NFC West play; offense ranks 2nd in passing success rate.
Totals: Panthers games lean UNDER when defense dominates; 49ers games lean OVER due to offensive firepower.
Final Score Projection: 49ers 30, Panthers 24
Reasoning: San Francisco’s offense led by Purdy and McCaffrey should edge Carolina, but the Panthers’ emerging passing attack and strong defense will keep it close. Expect the 49ers to win, but Carolina to cover the spread.
PANTHERS NOTES:
• PANTHERS last week became the first team since SF in Week 10 of the 2024 season to have 5 players with 50+ receiving yards in same game. • QB BRYCE YOUNG passed for franchise-record 448 yards, 3 TDs & 123.2 passer rating in Week 11. Became 5th QB under age-25 with 30+ completions, 425+ pass yards, 3+ TD passes & 0 INTs in single game in NFL history. Has pass TD in 9 of his past 10 road games. • RB RICO DOWDLE had 100 scrimmage yards (55 rec., 45 rush) in Week 11. Ranks 4th with 833 rush yards in 2025. Is 1 of 4 NFC RBs with an active streak of 50 scrimmage yards in 7+ consecutive games. Has rush TD in 2 of his past 3 games. • WR TETAIROA MCMILLAN had 8 catches for 130 yards & 2 TDs in Week 11 & became the 6th rookie since 2000 with 8+ catches, 130+ yards & 2 TDs in a game. Joined Ja’Marr Chase, Malik Nabers, Puka Nacua & Chris Olave as only rookies in last 5 seasons to record 50+ catches & 700+ yards in first 11 games. Ranks 1st among rookies & 5th in NFC with 748 receiving yards. • WR XAVIER LEGETTE had 4 catches for 83 yards & TD in Week 11. Has 80+ yards & TD in 2 of his past 3 road games. • LB CHRISTIAN ROZEBOOM had 10 tackles & TFL in last week. Aims for 3rd in row with 10+ tackles & TFL on road. Has 10+ tackles & TFL in 3 of his past 4 games. • CB MIKE JACKSON had 2 tackles & PD in Week 11. Tied-4th in 2025 with 11 PD. Has PD in 4 of his past 5 games. • CB COREY THORNTON had 5 tackles, 2 PD & FF in Week 11 & is 1 of 3 NFC DBs to record 5+ tackles, 2 PD & FF in single game this season. • S TRE’VON MOEHRIG had team-high 11 tackles in Week 11 & is 1 of 3 DBs to have 2 games of 11+ tackles in 2025. Has 5+ tackles in 7 of his past 8 road games. Has TFL in 2 of his past 3 road games.
49ERS NOTES:
• QB BROCK PURDY completed 19 of 26 att. (73.1 pct.) for 200 yards & 3 TDs in Week 11. Surpassed Patrick Mahomes (11 games) & Deshaun Watson (11) for the 2nd-most games with a passer rating of 125-or-higher (min. 15 att. in each game) by player in his 1st 4 seasons in NFL history. Aims for 6th in row with 200+ yards & 2+ TDs. Aims for 3rd in row with 300+ passing yards at home. • RB CHRISTIAN MCCAFFREY had 121 scrimmage yards (81 rush, 40 rec.) & 3 scrimmage TDs (2 rush, 1 rec.) in Week 11. Has 6 rush TDs & 5 rec. TDs this season, 1st player in NFL history to record 5+ rush & 5+ rec. TDs in 4 seasons, surpassing HOFerMarshall Faulk (3 seasons). Became the 5th player since 2000 with 2+ rush TD & 1+ rec. TD in 4 career games. Ranks 1st in 2025 with 1,439 scrimmage yards. • WR JAUAN JENNINGS had 4 catches for 54 yards in Week 11. Aims for 6th in row with 4+ catches. Aims for 5th in row with 40+ rec. yards. Has rec. TD in 2 of his past 3 games. • TE GEORGE KITTLE had 6 catches for 67 yards & 2 TDs in Week 11. Became the 5th TE in NFL history with 7,500+ rec. yards & 50 rec. TDs in player’s 1st 9 seasons. Aims for 5th in row with 4+ catches. Has rec. TD in 3 of his past 4 games. • LB CURTIS ROBINSON led team & had career-high 11 tackles in Week 11. Has 5+ tackles in 2 of his past 3 road games. • LB DEE WINTERS had 10 tackles & TFL in Week 11. Aims for 5th in row with 5+ tackles. Aims for 3rd in row with TFL. • DB DEOMMODORE LENOIR had 7 tackles, 2 PD & INT return yards in Week 11. Had 8 tackles in last meeting. • S JI’AYIR BROWN had 7 tackles in Week 11. Has 5+ tackles in 4 of his past 5 games. Has PD in 2 of his past 3 games.
Game Odds
Carolina Panthers 49.5
San Francisco 49ers – 7.5
Odds Courtesy of Sports Odd Direct as of Sunday, November 23, 2025
