Venue & Game Details
Location: Lucas Oil Stadium, 500 S. Capitol Ave, Indianapolis, IN 46225
Kickoff: 1:00 p.m. ET / 10:00 a.m. PT
Broadcast: FOX (regional), streaming on Fubo/NFL+
Weather Forecast (Indianapolis)
Temperature: ~56°F
Conditions: Clear skies
Wind: 6 mph NE
Impact: Minimal—Lucas Oil has a retractable roof, so weather will not affect play
Injury Report
Arizona Cardinals
QB Kyler Murray (foot) – Questionable
LG Evan Brown (hamstring) – Questionable
DE Darius Robinson (pectoral) – Questionable
CB Max Melton (hamstring) – Questionable
LB Cody Simon (knee) – Questionable
WR Zay Jones (knee) – Limited
TE Tip Reiman (ankle) – Out (IR)
RB James Conner (foot) – IR
Indianapolis Colts
WR Alec Pierce (concussion) – Questionable
CB Kenny Moore II (Achilles) – Questionable
RB Tyler Goodson (groin) – Questionable
DE Tyquan Lewis (illness) – Questionable
LB Joe Bachie (undisclosed) – Out (IR)
PK Spencer Shrader (knee) – Out (IR), Michael Badgley signed as replacement
Player Matchups
Kyler Murray (ARI QB) vs. Colts Secondary: Murray has 962 yards, 6 TDs, 3 INTs, plus 173 rushing yards. His mobility will test Indy’s banged-up secondary.
Jonathan Taylor (IND RB) vs. Cardinals Run Defense: Taylor has 480 yards and 6 TDs through 5 games, averaging 96 YPG. Arizona allows 118.2 rush YPG.
Marvin Harrison Jr. (ARI WR) vs. Charvarius Ward (IND CB): Harrison Jr. (306 yards, 2 TDs) faces Indy’s top corner in a marquee matchup.
Josh Sweat & Calais Campbell (ARI Pass Rush) vs. Colts O-Line: Sweat has 5 sacks; Campbell adds 3. Protecting Daniel Jones is critical.
Daniel Jones (IND QB) vs. Cardinals Defense: Jones has 1,290 yards, 6 TDs, 2 INTs, completing 71.3%. He’s been sacked only 4 times all season.
Team Records & Recent Form
Arizona Cardinals (2-3)
Last 5: L vs TEN (22-21), L vs SEA (23-20), L @ SF (16-15), W vs CAR (27-22), W @ NO (20-13)
Note: All 3 losses came on last-second field goals
Indianapolis Colts (4-1)
Last 5: W vs LV (40-6), L @ LAR (27-20), W @ TEN (41-20), W vs DEN (29-28), W vs MIA (33-8)
Note: Colts averaging 32.6 PPG (3rd in NFL)
Series History
All-time: Colts lead 9-8
Last meeting: Colts 22, Cardinals 16 (Christmas 2021)
Betting Trends
Colts: 4-1 ATS, 2-3 O/U
Cardinals: 2-3 ATS, 2-3 O/U
Colts are 3-0 at home this season
Cardinals have lost 3 straight by a combined 7 points
Arizona is 4-1 in last 5 vs AFC opponents
CARDINALS NOTES:
• QB KYLER MURRAY completed 23 of 31 atts. (season-high 74.2 pct.) for 220 yards with 0 INTs & 93.5 rating & had 1st rush TD of season last week. Has 32 career rush TDs, 3rd-most among QBs since 2019. Totaled 319 yards (245 pass, 74 rush) & had TD pass vs. 0 INTs in last meeting. Aims for his 5th in row vs. AFC with 0 INTs & 90+ rating. • RB EMARI DEMERCADO led team with career-high 81 rush yards last week. • RB MICHAEL CARTER had season-high 71 scrimmage yards (51 rush, 22 rec.) with rush TD & 5 catches in Week 5. Has 55+ scrimmage yards in 3 of his past 4 & rush TD in 2 of his past 3. Had 86 scrimmage yards (49 rush, 37 rec.) in only career game vs. Ind. (11/4/21 w/ NYJ). • RB BAM KNIGHT rushed for 1st TD of season last week. • WR MARVIN HARRISON JR. led team with 98 rec. yards in Week 5, 4th-career game with 95+ rec. yards. Aims for 3rd in row with 65+ rec. yards. Has 5+ catches & 70+ rec. yards in 2 of his past 3 on road. • TE TREY MCBRIDE had 5 catches for 41 yards last week & is 1 of 2 TEs (Jake Ferguson) with 5+ catches in 5 games this season. Has rec. TD in 2 of his past 3 on road. Has 50+ rec. yards in 4 of his past 4 vs. AFC. Ranks 2nd among TEs with 29 catches & 3rd with 275 rec. yards in 2025. • DL CALAIS CAMPBELL aims for his 4th in row vs. Ind. with TFL. • LB JOSH SWEAT had season-high 2 sacks & 1st PD of season last week, 7thcareer game with 2 sacks. Aims for 5th in row with sack. Ranks tied-3rd in NFL with 5 sacks in 2025. • LB MACK WILSON had 6 tackles & PD in Week 5. Has 6+ tackles in each of 5 games this season & PD in 4 of 5 games. Has TFL & PD in 3 of his past 4 on road. • S DADRION TAYLOR-DEMERSON had 2 PD & 2nd INT of season last week. Has INT in 2 of past 3. Aims for 3rd in row on road with PD. • S BUDDA BAKER has 5+ tackles in 23 straight games, longest active streak among DBs. Had 13 tackles, 2 TFL, sack & PD in last meeting.
COLTS NOTES:
• COLTS rank 2nd in NFL in scoring offense (32.6 points/game) & 3rd in scoring defense (17.9 points allowed/game) in 2025. • QB DANIEL JONES completed 20 of 29 atts. (69 pct.) for 212 yards & 2 TDs vs. 0 INTs with 113 rating last week. Is 1 of 2 in NFL (Matthew Stafford) with 105+ rating in 4 games this season. Is 3-0 with 7 TDs (4 pass, 3 rush) vs. 0 INTs & 111.7 rating in 3 home starts this season. Totaled 380 yards (321 pass, 59 rush) & 3 TDs (2 pass, 1 rush) with 103.5 rating in his last start vs. Ari. (9/17/23 w/ NYG). Ranks 3rd in NFL with 1,290 in pass yards in 2025. • RB JONATHAN TAYLOR had 86 scrimmage yards (66 rush, 20 rec.) & 3 rush TDs last week. Has 3 rush TDs in 2 of past 3 & is 6th player in SB era with 3+ rush TDs in multiple games within team’s 1st 5 games of season. Is 1 of 2 RBs (Christian McCaffrey) with 85+ scrimmage yards in 5 games this season. Rushed for 108 yards in last meeting. Leads NFL with 480 rush yards & 6 rush TDs in 2025. • RB AMEER ABDULLAH had rush TD in season debut last week. • WR MICHAEL PITTMAN has 5+ catches & rec. TD in 4 of 5 games this season, incl. in each of past 3. Had 8 catches for 82 yards in last meeting. • WR JOSH DOWNS had 6 catches for season-high 54 yards in Week 5. • TE TYLER WARREN (rookie) had 1st-career TD catch last week. Aims for 3rd in row with TD. Ranks 3rd among rookies with 23 catches & 307 rec. yards in 2025. • DT DEFOREST BUCKNER had 6 tackles & 1st sack of season in Week 5. Has TFL in 3 of past 4. Aims for 5th in row with 5+ tackles. Has sack in 2 of his past 3 vs. Ari. • DE LAIATU LATU had INT & TFL last week & is only DL with 2 INTs this season. • DE SAMSON EBUKAM had season-high 5 tackles & 2nd sack of season last week. Has TFL in 2 of past 3. Had half sack in his last game vs. Ari. (1/8/23 w/ SF). • LB ZAIRE FRANKLIN had 7 tackles & 1st sack of season last week. Aims for 5th in row with 5+ tackles. Has PD in 3 of past 4. • CB MEKHI BLACKMON had INT in Week 5. Aims for 5th in row with 5+ tackles.
Game Odds
Arizona Cardinals 46.5
Indianapolis Colts – 7
Odds Courtesy of Sports Odd Direct as of Saturday, October 11, 2025
