Kickoff is scheduled for 7:00 p.m. CT (8:00 p.m. ET)

Venue: Shell Energy Stadium — Houston, Texas

Weather Outlook — Houston, TX (Seasonal Expectation)

No direct weather data was returned in search results; based on late‑April Houston climate:

Temperature: Upper‑70s to mid‑80s

Conditions: Warm, humid

Wind: Light southerly breeze

Impact: Fast pitch, potential fatigue factor for visiting Louisville

Injury Report

No official injury lists were included in available sources. However, both clubs rotated heavily in the previous round, and Houston debuted multiple first‑time starters, suggesting squad depth is available.

Team Records & Recent Form

Houston Dynamo FC

Round of 32: 4–1 win vs. El Paso Locomotive

Ondřej Lingr: 1 goal + 2 assists

Ezequiel Ponce, Nick Markanich, Mateusz Bogusz: 1 goal each

Cup Pedigree:

Two‑time U.S. Open Cup champions (2018, 2023)

Never trailed during their 2023 title run

Recent Form: Strong attacking output; multiple players scoring and assisting

Louisville City SC

Round of 32: 2–1 win at Austin FC

Goals: Sean Totsch (26’), Tola Showunmi (32’)

Cup Notes:

Second‑ever win over an MLS opponent

Off to a 7‑1‑1 start across all competitions in 2026

Road Cup History:

0–5 all‑time away at MLS clubs

Series History

First competitive meeting between the clubs.

They previously met only in preseason (2021, 2024).

Key Player Matchups

Ondřej Lingr (HOU) vs. Louisville Midfield

Lingr was the star of the Round of 32 with three goal contributions, and his ability to break lines will be a major challenge for Louisville.

Totsch & Showunmi (LOU) vs. Houston Back Line

Louisville’s early‑goal pairing stunned Austin FC; their physicality and timing will test Houston’s center‑backs.

Mateusz Bogusz (HOU) vs. Louisville Defensive Shape

Bogusz scored 22 seconds into the second half vs. El Paso, highlighting his ability to exploit disorganization.

Betting Trends

Houston Dynamo

Scored 4 goals in previous round

Multiple players in scoring form

Strong historical Cup pedigree

Louisville City

Riding a 7‑1‑1 start to 2026

Historically struggle away at MLS venues (0–5)

Dangerous early in matches

MATCH ODDS

Louisville City SC              + 340

Houston Dynamo FC       – 155

Draw                                     + 300

Over 2.5 – 165                   Under 2.5 + 130

Odds Courtesy of Sports Odds Direct as of Tuesday, April 28, 2026

Kickoff is scheduled for 7:00 p.m. CT

Venue: SeatGeek Stadium — Bridgeview, Illinois

Broadcast: Paramount+

Weather Outlook — Bridgeview, IL (Seasonal Expectation)

No direct weather data was returned in search results; based on late‑April Chicago climate:

Temperature: Low‑50s to mid‑60s

Conditions: Partly cloudy, cool

Wind: Moderate breeze (typical for open‑air SeatGeek Stadium)

Impact: Slight advantage to high‑pressing teams; ball moves quickly on a cool pitch

Injury Report

No official injury lists were included in available sources. Both clubs are expected to rotate but field strong lineups due to knockout stakes.

Team Records & Recent Form (U.S. Open Cup)

Chicago Fire FC

Round of 32: 2–1 win vs. Detroit City FC

Jason Shokalook: Scored twice in two minutes in his first start

Cup Pedigree:

Four‑time U.S. Open Cup champions (1998, 2000, 2003, 2006)

Most wins and semifinal appearances by any MLS club

St. Louis CITY SC

Round of 32: 4–0 win vs. FC Tulsa

Goals: Marcel Hartel, Jeong Sang‑Bin, Mykhi Joyner, Tomás Ostrák

Roman Bürki recorded an assist

Second consecutive Round of 16 appearance

Series History

This is the first U.S. Open Cup meeting between the clubs.

MLS meetings have been competitive, but St. Louis’ high‑tempo style contrasts sharply with Chicago’s possession‑oriented approach.

Key Player Matchups

Jason Shokalook (CHI) vs. St. Louis Back Line

Coming off a breakout two‑goal performance.

St. Louis’ center‑backs must track his late runs and movement.

Marcel Hartel & Jeong Sang‑Bin (STL) vs. Chicago Midfield

Both scored in the previous round and thrive in transition.

Chicago must control midfield tempo to prevent CITY SC counterattacks.

Roman Bürki (STL) vs. Chicago Attack

Bürki not only anchors the defense but contributed an assist in the last round.

His distribution can break Chicago’s press.

Betting Trends

Chicago Fire FC

Strong historical Cup performance

Shokalook in form

Home‑field advantage at SeatGeek Stadium

St. Louis CITY SC

Entering with a dominant 4–0 win

Bürki’s distribution and shot‑stopping elevate CITY SC in knockout play

MATCH ODDS

St. Louis City SC                + 260

Chicago Fire FC                 – 115

Draw                                     + 265

Over 2.5 – 160                   Under 2.5 + 125

Odds Courtesy of Sports Odds Direct as of Tuesday, April 28, 2026

Kickoff: 7:30 p.m. ET

Venue: ScottsMiracle‑Gro Field — Columbus, Ohio

Broadcast: Paramount+

Weather Outlook — Columbus, OH (Seasonal Expectation)

No direct weather data was returned in search results; based on late‑April Columbus climate:

Temperature: Mid‑50s to low‑60s

Conditions: Partly cloudy

Wind: Light breeze

Impact: Cool, fast pitch conditions — ideal for high‑tempo play

Injury Report

No official injury lists were included in available sources. Both clubs are expected to enter with standard rotation for a knockout match.

Team Records & Recent Form

Columbus Crew SC

Round of 32: 3–0 win vs. Richmond Kickers (away)

Recent Form (all competitions):

L 2–1 vs. NE

W 3–0 vs. Richmond (Cup)

D 1–1 vs. Orlando

W 3–1 vs. Atlanta

L 2–1 vs. Toronto

Open Cup History:

23‑14‑13 all‑time record

2002 U.S. Open Cup champions

One Knoxville SC

Round of 32: Advanced with strong early‑round form (3 goals in multiple matches)

Recent Form (all competitions):

W 2–1 vs. Cincinnati

W 3–3 vs. D.C. United (advanced)

D 0–0 vs. Portland

W 2–1 vs. Sacramento

W 1–1 vs. Asheville

Top Scorers (Cup):

B. Diene — 2 goals

D. Krioutchenkov — 2 goals

M. Gøling — 1 goal

Key Player Matchups

H. Picard (CLB) vs. Knoxville Back Line

Picard leads Columbus with 2 goals in the tournament.

His movement between lines will challenge Knoxville’s defensive shape.

Jamal Thiaré (CLB) vs. Knoxville Center‑Backs

Scored in his lone Cup appearance; a physical presence up top.

Diene & Krioutchenkov (KNX) vs. Columbus Defensive Unit

Both Knoxville forwards have 2 goals in the Cup and are the primary threat in transition.

Midfield Battle: Ruvalcaba & Sejdic (CLB) vs. Knoxville’s Press

Both Crew midfielders have registered assists in the Cup.

Knoxville’s defensive midfield must disrupt Columbus’ rhythm.

Series History

This is the first competitive meeting between the clubs.

Columbus holds a significant experience advantage as an MLS side with deep Open Cup history.

Betting Trends

Columbus Crew

Strong home form historically in the Cup.

Multiple goals scored in recent matches.

Clean sheet in Round of 32.

One Knoxville SC

Entering with momentum after multiple positive results.

Dangerous in transition and set pieces.

Lower‑division sides often play with nothing to lose — volatility factor.

MATCH ODDS

One Knoxville SC             + 650

Columbus Crew SC          – 330

Draw                                     + 450

Over 3.5 + 140                  Under 3.5 – 175

Odds Courtesy of Sports Odds Direct as of Tuesday, April 28, 2026

Kickoff: 7:30 p.m. ET

Venue: Centreville Bank Stadium — Pawtucket, Rhode Island

Broadcast: Paramount+

Weather Outlook — Pawtucket, RI (Seasonal Expectation)

No direct weather data was returned in search results; based on late‑April Rhode Island climate:

Temperature: Mid‑50s to low‑60s

Conditions: Partly cloudy, light breeze

Impact: Cool, fast pitch conditions — ideal for high‑tempo play

Injury Report

No official injury lists were included in available sources. Both clubs are expected to rotate but field strong lineups due to knockout stakes.

Orlando enters healthy after a controlled 1–0 win.

New England played 120 minutes + penalties in their previous round.

Team Records & Recent Form (U.S. Open Cup)

Orlando City SC

Advanced with a 1–0 win vs. FC Naples on April 15, courtesy of a long‑range strike from Tyrese Spicer.

Reached the Round of 16 for the second straight year and seventh time in nine MLS‑era campaigns.

Former 2022 U.S. Open Cup champions.

New England Revolution

Advanced via 3–1 penalty shootout vs. Rhode Island FC after a 1–1 draw in regulation.

Have reached this round in four of their last five tournament appearances and eight of their last 11 since 2013.

Series History (U.S. Open Cup & MLS Context)

No recent Open Cup meetings between the clubs.

MLS meetings have historically been competitive, with Orlando often performing well in knockout‑style matches.

Key Player Matchups

Tyrese Spicer (ORL) vs. New England Back Line

Scored the decisive goal in the Round of 32.

His pace and long‑range threat will test a Revolution defense that played 120 minutes last round.

Carles Gil (NE) vs. Orlando Midfield

Gil remains New England’s creative engine.

Orlando’s midfield must limit his touches between the lines.

Orlando’s Press vs. New England’s Build‑Up

Orlando thrives in transition and high‑pressure moments.

New England may rotate after a physically taxing previous match.

Betting Trends

Orlando City

Strong Cup pedigree (2022 champions).

Enter with momentum after a clean sheet win.

Historically strong in knockout environments.

New England Revolution

Home‑field advantage at a new, energized venue.

Strong Cup consistency (8 Round‑of‑16 appearances in 11 years).

Fatigue factor after extra‑time match.

MATCH ODDS

Orlando City SC                                + 205

New England Revolution              + 115

Draw                                                     + 250

Over 2.5 – 140                   Under 2.5 + 110

Odds Courtesy of Sports Odds Direct as of Tuesday, April 28, 2026

Kickoff: 7:00 p.m. ET

Venue: Sports Illustrated Stadium — Harrison, New Jersey

Broadcast: Paramount+ / CBS Sports Network

Weather Outlook — Harrison, NJ (Seasonal Expectation)

No direct weather data was returned in search results; based on late‑April New Jersey climate:

Temperature: Low‑60s at kickoff

Conditions: Partly cloudy

Wind: Light breeze

Impact: Ideal for high‑tempo pressing; no expected weather disruption

Injury Report

No official injury lists were included in available sources. Both clubs are expected to enter with standard rotation for a knockout match.

Team Records & Recent Form (U.S. Open Cup)

New York Red Bulls

Round of 32: 3–1 win vs. Pittsburgh Riverhounds SC

Julian Hall: Brace (now 7 goals across all competitions)

Emil Forsberg: 1 goal + 1 assist (3 career Open Cup goal contributions)

Home Cup Dominance:

13‑1‑4 in home U.S. Open Cup matches since 2010

11‑0‑4 all‑time at Sports Illustrated Stadium in the tournament

Open Cup vs. NYCFC:

3‑0‑0, outscoring NYCFC 8–0 in Cup play

New York City FC

NYCFC confirmed the matchup on April 16 and will travel to Harrison for the Round of 16.

NYCFC has reached the Quarterfinals twice in club history.

NYCFC II reached the Round of 16 in 2024, the deepest run ever by an MLS NEXT Pro side.

Series History (All Competitions)

Red Bulls historically dominate the rivalry in the U.S. Open Cup (8–0 aggregate across three matches).

MLS regular‑season meetings are more balanced, but Cup history heavily favors RBNY.

Key Player Matchups

Julian Hall (RBNY) vs. NYCFC Back Line

Hall enters in elite form with a brace in the previous round and seven goals across competitions. His pace and movement will challenge NYCFC’s center‑backs.

Emil Forsberg (RBNY) vs. NYCFC Midfield

Forsberg’s creativity and set‑piece quality are central to RBNY’s attack. NYCFC must limit his touches between the lines.

NYCFC Attack vs. RBNY Press

NYCFC’s buildup will be tested by the Red Bulls’ trademark high press, especially in a knockout setting.

Betting Trends

Red Bulls:

Unbeaten in 15 straight home Open Cup matches (11‑0‑4).

Perfect 3‑0‑0 vs. NYCFC in Cup play.

Enter with strong attacking form (3 goals vs. Pittsburgh).

NYCFC:

Historically inconsistent in the Open Cup but capable of deep runs.

Road form in knockout competitions has been mixed.

MATCH ODDS

New York City FC              + 115

New York Red Bulls         + 195

Draw                                     + 255

Over 2.5 – 150                   Under 2.5 + 115

Odds Courtesy of Sports Odds Direct as of Tuesday, April 28, 2026

Kickoff: 7:00 p.m. PT / 9:00 p.m. CT

Venue: PayPal Park — San Jose, California

Broadcast: Paramount+ / CBS Sports Golazo Network

Weather Outlook — San Jose, CA (Inferred Seasonal Conditions)

No direct weather data was returned in search results; based on late‑April San Jose climate:

Temperature: Low‑60s at kickoff

Conditions: Clear, dry, light coastal breeze

Impact: Ideal for high‑tempo play; minimal weather disruption

Injury Report

Minnesota United FC

Peter Stroud — Quadriceps: Back in training; could return soon.

James Rodríguez — Illness: Played 66 minutes in previous Cup match; recovering well.

San Jose Earthquakes

Timo Werner — Lower body: Played one half and recorded an assist in last Cup match; confirmed fit.

Team Records & Recent Form

San Jose Earthquakes

Recent Results:

2–0 win vs. Phoenix Rising (U.S. Open Cup)

MLS form entering the match: W3–1, W3–0, W1–0, L1–0

Win Probability: 43.9% (home favorite)

Minnesota United FC

Recent Results:

Advanced after a 12‑round penalty shootout vs. Sacramento Republic following a 0–0 draw over 120 minutes.

MLS form entering the match: W2–1, W2–1, D0–0, L6–0

Win Probability: 28.6% (away underdog)

Series History (MLS Head‑to‑Head)

Minnesota has dominated the recent rivalry:

Jul 12, 2025: MIN 4–1 SJ

Mar 8, 2025: SJ 0–1 MIN

Aug 31, 2024: SJ 1–2 MIN

Jul 20, 2024: MIN 2–0 SJ

Sep 30, 2023: MIN 1–1 SJ

Trend: Minnesota unbeaten in last five vs. San Jose (4 wins, 1 draw).

Key Player Matchups

Timo Werner (SJ) vs. Minnesota’s Back Line

Returned from injury with an assist in the last Cup match.

His pace and directness will test Minnesota’s defensive shape.

Minnesota’s Midfield (Rodríguez, Stroud) vs. San Jose’s Press

Rodríguez’s return to fitness is crucial for ball progression.

Stroud’s potential availability adds stability.

Goalkeeper Duel: Alec Smir (MIN) vs. San Jose Attack

Smir was heroic in the 12‑round shootout vs. Sacramento.

San Jose enters with strong attacking form and multiple recent multi‑goal wins.

Venue Impact — PayPal Park

San Jose holds hosting priority and earned home field by winning their Round of 32 match.

Minnesota travels west after a grueling 120‑minute match + shootout.

Betting Trends

San Jose

4 wins in last 5 across all competitions.

Multiple clean sheets recently (2–0, 3–0, 1–0).

Minnesota

Riding emotional momentum after dramatic shootout win.

Historically strong vs. San Jose (4 wins in last 5).

MATCH ODDS

Minnesota United FC     + 310

San Jose Earthquakes    – 145

Draw                                     + 310

Over 3.5 + 110                  Under 3.5 – 165

Odds Courtesy of Sports Odds Direct as of Monday, April 27, 2026

Kickoff: 7:00 p.m. ET

Venue: Mecklenburg County Sportsplex, Matthews, North Carolina

Broadcast: Paramount+ / CBS Sports Network

Weather Outlook — Matthews, NC

No official match‑day forecast was provided in sources; typical late‑April conditions in Matthews are mild.

Expected Temperature: Mid‑60s to low‑70s (historical average)

Conditions: Partly cloudy, low chance of rain

Impact: Favorable for high‑tempo play; minimal weather disruption expected

(Weather is inferred from seasonal norms; no direct weather data was returned in search.)

Injury Report

No official injury lists were included in available sources. Both clubs are expected to enter with standard squad rotation for a knockout match.

Team Records & Recent Form (U.S. Open Cup)

Charlotte FC

Round of 32: 6–0 win vs. Charlotte Independence

Goals: Goodwin, Kessler, Berchimas, Schnegg, Vargas, Coulibaly

Independence played down a man for 67 minutes after a red card

Form: Dominant, high‑scoring, confident entering Round of 16

Atlanta United FC

Round of 32: 3–1 win vs. Chattanooga FC

Goals: Togashi, Picault, Amador

Came from behind after conceding early

Form: Resilient, strong second‑half performance, improved attacking cohesion

Head‑to‑Head History (MLS Matches)

Charlotte has had the upper hand recently:

Jul 19, 2025: Charlotte 3–2 Atlanta

Mar 1, 2025: Charlotte 2–0 Atlanta

Aug 31, 2024: Atlanta 1–0 Charlotte

Jun 2, 2024: Charlotte 3–2 Atlanta

May 13, 2023: Charlotte 3–1 Atlanta

Trend: Charlotte has won 4 of the last 5 meetings.

Key Player Matchups

Charlotte FC Attack vs. Atlanta Back Line

Charlotte’s Round‑of‑32 scorers (Goodwin, Kessler, Berchimas, Schnegg, Vargas, Coulibaly) showed multi‑channel attacking threats.

Atlanta must manage wide overloads and late box runners.

Atlanta’s Front Three vs. Charlotte’s Defensive Shape

Togashi, Picault, and Amador all scored in the previous round.

Atlanta thrives in transition; Charlotte’s fullbacks will be tested.

Midfield Control

Charlotte’s R. Aloko leads with 2 assists in the tournament so far.

Atlanta’s Fortune and Brennan each have 1 assist, key to linking play.

Betting Trends

Charlotte FC

Entering with a 6–0 Cup win; high‑confidence attack

Strong historical record vs. Atlanta

Home‑field advantage at Matthews

Atlanta United FC

Scored 3 goals in comeback fashion in Round of 32

More volatile defensively

Dangerous in transition and late‑game surges

MATCH ODDS

Atlanta United FC            + 230

Charlotte FC                       + 105

Draw                                     + 245

Over 2.5 – 145                   Under 2.5 + 115

Odds Courtesy of Sports Odds Direct as of Monday, April 27, 2026