MLB Game Preview: St. Louis Cardinals (61-61) vs. Chicago Cubs (72-51)

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Chicago Cubs logo

Wrigley Field, Chicago, IL.

First pitch: Approximately 2:20 p.m. ET / 1:20 p.m. CT.

TV: Marquee Sports Network and Cardinals.TV.

This is Game 2 of a three-game series (Cubs lead 1-0 after a 3-0 shutout Friday behind Clay Holmes and a Seiya Suzuki three-run homer). The Cubs sit second in the NL Central (3 games behind Milwaukee), while the Cardinals are third (13.5 games back) and on the fringe of the wild-card race.

Starting Pitchers

Cardinals: RHP Michael McGreevy (4-9, 3.64 ERA, 1.22 WHIP, 126 IP, 85 K, 32 BB in 23 starts). He has struggled recently (higher ERA in last several outings, including a disastrous 1.2 IP, 7 ER vs. Cubs on July 28). Career vs. Cubs: poor (roughly 7.94 ERA in limited starts). xERA is notably higher than actual ERA, indicating some regression risk.

Cubs: LHP Matthew Boyd (8-1, 3.50 ERA, 1.22 WHIP, 79.2 IP, 66 K, 23 BB in 14 starts). Excellent since returning from a torn meniscus (activated ~June 25); Cubs are 8-1 in his last nine starts (2.43 ERA range in that stretch). Strong recent form includes 7 IP, 2 ER vs. Royals. Career vs. Cardinals: solid (around 1.58 ERA in limited starts).

Boyd has the edge in recent form, win rate, and matchup history.

Probable Lineups

Cardinals: JJ Wetherholt 2B, Iván Herrera DH, Jordan Walker RF, Alec Burleson 1B, Joshua Báez LF (expected MLB debut for the prospect), Masyn Winn SS, others including potential contributions from Pagés C, Pereira CF, etc.

Cubs: Pete Crow-Armstrong CF, Seiya Suzuki RF, Michael Busch 1B, Alex Bregman 3B, Ian Happ LF, Nico Hoerner SS, Pedro Ramírez 2B, Michael Conforto DH, Miguel Amaya C (Dansby Swanson resting in some reports).

Key Cardinals bats: Burleson (~.285 AVG, strong RBI production), Walker (power/RBI leader). Cubs: Crow-Armstrong (.279/.378/.534, 27 HR, 30 SB range — elite speed/power), Suzuki (hot second half, recent 3-run HR), Bregman, Happ, Hoerner.

Injury Reports

Cardinals: Ramón Urías (3B, 60-day IL, elbow), Max Rajcic (SP, 60-day IL, elbow). Limited other major absences noted for position players.

Cubs: Multiple arms out — Justin Steele, Cade Horton, Shelby Miller, Hunter Harvey, Porter Hodge, Riley Martin (various elbow/forearm/triceps, mostly 60-day); Edward Cabrera (hamstring, 15-day, potentially nearing return for Sunday); Phil Maton (knee), Daniel Palencia (elbow), Gavin Hollowell (shoulder), Hoby Milner (abdomen/appendicitis-related), Matt Shaw (hand, 10-day), Ben Brown (neck). Depth is tested but starting rotation is functional with Boyd.

Weather Forecast

Wrigley Field: Mostly cloudy/overcast, highs around 75–80°F (upper 70s to low 80s), humid (high humidity, heat index potentially higher). Chance of showers/thunderstorms (40–70% at times, especially earlier or later), winds ~5–10 mph (SE/S/SW). Possible light precipitation impact but game expected to proceed; conditions favor neither extreme offense nor pure pitching dominance.

Recent Team Forms

Cardinals: 6-4 last 10; mixed results (recent wins over Phillies and Rockies, loss Friday). Offense around 4.3 RPG; pitching ERA ~4.07.

Cubs: 8-2 last 10 (strong, including Friday shutout); potent offense (~5.2 RPG, strong OBP/SLG), pitching ERA also ~4.07 but better home performance and recent results. They are scoring and winning consistently while chasing the division.

Series History (2026)

Cubs lead the season series (roughly 6-5 after Friday’s win). Recent meetings: Cubs took the last one 3-0 (Aug 14); prior July series saw mixed results (Cubs won several, including a 10-2 rout of McGreevy). Historical rivalry is long and close (Cubs slight all-time edge).

Key Player vs. Player / Matchup Notes

McGreevy (RHP) vs. Cubs lefty-heavy or contact-oriented bats (Crow-Armstrong, Happ, etc.): Cubs hit well vs. RHP recently; they previously crushed McGreevy.

Boyd (LHP) vs. Cardinals righty-leaning order (Walker, Burleson, Winn, Herrera): Boyd’s post-injury command and ground-ball tendencies help; Cardinals rank lower vs. LHP in some metrics.

Speed/power threats: Crow-Armstrong (SB/HR threat) vs. Cardinals defense; Suzuki’s power; Cardinals’ Walker/Burleson production.

Prospect Báez debut adds intrigue for St. Louis outfield depth.

Betting Trends

Cubs strong at home and in Boyd starts; Cardinals inconsistent on road and vs. lefties lately. H2H unders have hit in some recent games; Cubs offense can push totals when clicking.

GAME ODDS

St. Louis Cardinals           9

Chicago Cubs                     – 183

Odds Courtesy of Sports Odds Direct as of Friday, August 14, 2026

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