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MLB Game Preview: St. Louis Cardinals (48-42) vs. Chicago Cubs (53-36)

The Chicago Cubs and St. Louis Cardinals wrap up their three-game weekend series in a classic NL Central rivalry showdown at Wrigley Field. With the Cubs looking to extend their division lead and the Cardinals trying to stay in the Wild Card hunt, this nationally televised matchup carries significant midseason implications.

Game Details

MatchupSt. Louis Cardinals vs Chicago Cubs
DateSunday, July 6, 2025
First Pitch6:10 PM ET
VenueWrigley Field, Chicago, IL
BroadcastESPN, Marquee Sports Network, Bally Sports Midwest, MLB.tv
SeriesGame 3 of 3-game set (Series tied 1–1)

Team Records & Recent Form

TeamRecordLast 10 GamesDivision Rank
Chicago Cubs53–367–31st in NL Central
St. Louis Cardinals48–426–43rd in NL Central
  • The Cubs have won 6 of their last 7 games as favorites and lead the division by 3.5 games.
  • The Cardinals are 3–4 in their last 7 games as underdogs and are 25–24 on the road this season.

Starting Pitching Matchup

Chicago Cubs: Matthew Boyd (8–3, 2.65 ERA)

  • 98.2 IP, 87 K, 1.08 WHIP
  • Has allowed 2 or fewer earned runs in 4 of his last 5 starts
  • Opponents hitting just .235 against him
  • Pitched 6 scoreless innings vs. Cardinals earlier this season

St. Louis Cardinals: Erick Fedde (3–8, 4.56 ERA)

  • 91.2 IP, 76 K, 1.42 WHIP
  • Struggled with command and consistency
  • High walk rate and vulnerable to power-hitting lineups
  • Faces a Cubs offense ranked 3rd in MLB in slugging (.450)

Players to Watch

Chicago Cubs

  • Pete Crow-Armstrong: .274 AVG, 23 HR, 67 RBI – 7th in MLB in home runs, 9th in RBI
  • Seiya Suzuki: .281 AVG, 24 HR, 74 RBI – leads team in both HR and RBI
  • Michael Busch: .288 AVG – team leader in batting average
  • Dansby Swanson: .265 AVG, 15 HR – 3-game hitting streak

St. Louis Cardinals

  • Brendan Donovan: .293 AVG – team leader in batting average, 3-game hitting streak
  • Lars Nootbaar: 11 HR – projected to bat 6th, could see fewer plate appearances
  • Nolan Arenado: .244 AVG, 10 HR, 39 RBI – veteran slugger with power potential
  • Willson Contreras: 11 HR, 51 RBI – leads team in RBI

Injury Report Highlights

Chicago Cubs

  • Justin Steele – 15-day IL (forearm)
  • Jameson Taillon – 60-day IL (back)
  • Nick Madrigal – day-to-day (hamstring)

St. Louis Cardinals

  • Tommy Edman – 60-day IL (wrist)
  • Dylan Carlson – 10-day IL (ankle)
  • Giovanny Gallegos – 15-day IL (shoulder)

Game Odds

St. Louis Cardinals           7.5

Chicago Cubs                     – 205

Odds Courtesy of Sports Odd Direct as of Saturday, July 5, 2025

Mikey Balhan Sports

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