MLB Game Preview: St. Louis Cardinals (29-24) vs. Milwaukee Brewers (32-20)

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First Pitch: 7:10 PM CT

Venue: American Family Field, Milwaukee, WI

Capacity: 41,900

Surface: Kentucky Bluegrass

Roof: Retractable (expected closed)

Broadcast: Bally Sports Midwest, Bally Sports Wisconsin, MLB.TV

WEATHER REPORT — AMERICAN FAMILY FIELD (MILWAUKEE, WI)

Roof expected closed due to cool temperatures and wind.

  • Outside Temp: 63°F
  • Wind: 12–16 mph crosswind
  • Humidity: 60%
  • Rain: 20% chance (irrelevant with roof closed)

Ballpark Impact: With the roof closed, neutral to slightly pitcher‑friendly conditions. Ball does not carry as well indoors.

INJURY REPORT

St. Louis Cardinals

  • Nolan Arenado — ACTIVE (back stiffness managed)
  • Lars Nootbaar — QUESTIONABLE (hamstring tightness)
  • Tommy Edman — IL (wrist)
  • Steven Matz — IL (forearm)
  • Ryan Helsley — ACTIVE (normal workload)

Milwaukee Brewers

  • Christian Yelich — ACTIVE (quad soreness but expected to play)
  • Willy Adames — QUESTIONABLE (hand contusion)
  • Jackson Chourio — ACTIVE (minor ankle tweak)
  • DL Hall — IL (shoulder)
  • Closer Devin Williams — IL (back)

TEAM RECORDS & RECENT FORM

St. Louis Cardinals (29–24)

  • Last 10 games: 6–4
  • Road record: 13–12
  • Run differential: +8
  • Strength: Rotation stabilizing, improved OBP
  • Weakness: Inconsistent middle relief

The Cardinals have won 5 of their last 7, with the rotation finally delivering quality starts.

Milwaukee Brewers (32–20)

  • Last 10 games: 7–3
  • Home record: 17–9
  • Run differential: +31
  • Strength: Athletic lineup, elite bullpen depth even without Williams
  • Weakness: Back‑end rotation uncertainty

Milwaukee continues to lead the NL Central with a balanced attack and strong late‑inning performance.

STARTING PITCHING MATCHUP

Dustin May — RHP, Cardinals

  • 2026 ERA: 3.54
  • WHIP: 1.18
  • K/BB: 3.8
  • Last 3 starts: 17.2 IP, 7 ER, 19 K
  • Pitch mix: 98 mph sinker, cutter, curve, change

May’s sinker/curve combo has been sharp since returning from injury. He generates elite ground‑ball rates and limits hard contact.

Concern: Brewers’ lineup excels vs high‑velocity sinkers (Yelich, Chourio, Hoskins).

Milwaukee Brewers — TBD

Milwaukee is expected to choose between:

Option 1 — Tyler Blackwell (RHP)

  • ERA: 4.22
  • Profile: Strike‑thrower, average velocity, relies on weak contact
  • Issue: Cardinals hit soft‑tossing righties well

Option 2 — Bullpen Game

  • Opener: Joel Payamps or Elvis Peguero
  • Middle innings: Bryse Wilson, Aaron Ashby
  • Brewers bullpen ERA last 10 games: 3.21

Advantage: Cardinals (starting pitching), Brewers (bullpen)

KEY PLAYER MATCHUPS

1. Paul Goldschmidt (STL) vs. Milwaukee RHPs

  • Career at AmFam Field: .310 AVG, .940 OPS
  • Crushes fastballs <95 mph
  • If Brewers go with Blackwell, Goldy has a major edge

Edge: Cardinals

2. Christian Yelich (MIL) vs. Dustin May

  • Yelich vs sinkers: .302 AVG, .520 SLG
  • May’s sinker is elite, but Yelich handles velocity well

Edge: Even

3. Jackson Chourio (MIL) vs. Cardinals Bullpen

  • Chourio has 5 HR in his last 12 games
  • Cardinals middle relief has allowed the 3rd‑highest HR rate in NL over last 2 weeks

Edge: Brewers

4. Nolan Arenado (STL) vs. Milwaukee’s Soft‑Tossers

  • Arenado excels vs pitchers who rely on command
  • If Brewers use a bullpen game, he’ll see multiple favorable matchups

Edge: Cardinals

SERIES HISTORY

  • 2026 season series: Brewers lead 2–1
  • Last 20 meetings: Brewers 11, Cardinals 9
  • At American Family Field since 2023: Brewers 19–15
  • Average runs per game: 8.2

Milwaukee has had a slight edge in recent years, especially at home.

BETTING TRENDS

St. Louis Cardinals

  • 5–2 last 7 games
  • 4–1 last 5 road games
  • Under is 6–3 in last 9 May starts

Milwaukee Brewers

  • 7–3 last 10 games
  • 6–1 last 7 home games
  • Under is 5–2 in last 7 at AmFam Field

Head‑to‑Head

  • Brewers are 4–1 in last 5 meetings
  • Under is 5–2 in last 7 matchups
  • First‑five innings Under is 6–3 in last 9

Game Odds

St. Louis Cardinals           8.5

Milwaukee Brewers       – 155

Odds Courtesy of Sports Odds Direct as of Tuesday, May 26, 2026