MLB Game Preview: St. Louis Cardinals (29-23) vs. Milwaukee Brewers (31-20)

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Milwaukee Brewers logo

First Pitch: 7:10 PM CT

Venue: American Family Field — Milwaukee, Wisconsin

Probable Pitchers: RHP Michael McGreevy (STL) vs. RHP Tyler Harrison (MIL)

Venue Profile — American Family Field

  • Location: Milwaukee, WI
  • Roof: Expected CLOSED (forecast cool + chance of showers)
  • Dimensions: LF 342 ft, CF 400 ft, RF 345 ft
  • Park Factor: One of the most hitter-friendly domes in MLB
  • Notes:
    • Closed roof boosts carry to left-center.
    • Right-handed power plays extremely well here.

Weather Forecast

Roof expected closed — minimal weather impact on gameplay.

  • Outside Temperature: 63°F
  • Wind: 10–14 mph from the west
  • Humidity: 62%
  • Precipitation: 30% chance of light rain
  • Impact:
    • With the roof closed, conditions favor consistent offense and stable pitching mechanics.
    • Ball tends to jump in this park under dome conditions.

Injury Report

St. Louis Cardinals

  • Nolan Arenado — Day-to-day (back stiffness)
  • Tommy Edman — 10‑day IL (wrist)
  • Lars Nootbaar — 15‑day IL (oblique)
  • Giovanny Gallegos — 60‑day IL (shoulder)

Milwaukee Brewers

  • Christian Yelich — Day-to-day (knee soreness)
  • Brice Turang — 10‑day IL (ankle)
  • Robert Gasser — 60‑day IL (elbow)
  • Trevor Megill — 15‑day IL (forearm)

Team Records & Recent Form

St. Louis Cardinals (29–23)

  • Last 10: 6–4
  • Road Record: 13–12
  • Run Differential: +14
  • Trend: Pitching improving; offense inconsistent without Nootbaar and Edman.

Milwaukee Brewers (31–20)

  • Last 10: 7–3
  • Home Record: 17–9
  • Run Differential: +33
  • Trend: One of MLB’s hottest teams; lineup depth carrying them.

Pitching Matchup Breakdown

STL — RHP Michael McGreevy

  • 2026 Stats: 4.11 ERA | 1.28 WHIP | 6.9 K/9
  • Profile:
    • Pitch-to-contact righty with heavy sinker usage.
    • Relies on ground balls; struggles when forced up in the zone.
    • Vulnerable to power-heavy lineups in hitter-friendly parks.
  • Matchup Notes:
    • Brewers are top‑10 in MLB in hard-hit rate vs. sinkers.
    • American Family Field is a bad matchup for his fly-ball tendencies when behind in counts.

MIL — RHP Tyler Harrison

  • 2026 Stats: 3.32 ERA | 1.17 WHIP | 10.4 K/9
  • Profile:
    • Power righty with elite swing-and-miss slider.
    • Generates strikeouts in bunches; struggles occasionally with walks.
    • Excellent at home (2.71 ERA at American Family Field).
  • Matchup Notes:
    • Cardinals’ lineup is right-handed heavy, which plays into Harrison’s strengths.
    • STL struggles vs. high-spin breaking balls.

Key Player Matchups

Cardinals Hitters vs. Harrison

  • Paul Goldschmidt: Still dangerous vs. RHP but declining vs. elite velocity.
  • Willson Contreras: Good vs. sliders; potential RBI threat.
  • Jordan Walker: Power bat but high K-rate vs. high-spin arms.

Brewers Hitters vs. McGreevy

  • William Contreras: Elite vs. sinkers; HR candidate.
  • Rhys Hoskins: Perfect matchup for his uppercut swing.
  • Sal Frelick: Contact hitter who thrives vs. pitch-to-contact arms.

Series History

  • 2025 Season: Brewers won 10–9.
  • 2026 Season (so far): Brewers lead 2–1.
  • At American Family Field (last 3 years): Brewers 17–12.
  • Trend: Milwaukee consistently out-hits St. Louis in this park.

Betting Trends

St. Louis Cardinals

  • Under is 6–2 in last 8 road games
  • Cardinals 2–5 in last 7 vs. winning teams
  • McGreevy starts: Over is 5–2 in his last 7

Milwaukee Brewers

  • 7–1 in last 8 home games
  • Brewers 10–3 in last 13 vs. NL Central
  • Harrison starts: Brewers 8–2 in his last 10

Head-to-Head

  • Brewers 6–2 in last 8 meetings
  • Over is 7–3 in last 10 at American Family Field

Game Odds

St. Louis Cardinals           8

Milwaukee Brewers       – 170

Odds Courtesy of Sports Odds Direct as of Monday, May 25, 2026