MLB Game Preview: St. Louis Cardinals (29-21) vs. Cincinnati Reds (26-25)

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Cincinnati Reds logo

Venue: Great American Ball Park — Cincinnati, Ohio

First Pitch: 1:40 PM ET

Broadcast: Bally Sports Midwest, Bally Sports Ohio, MLB.TV

The Cardinals and Reds close out their weekend series in a matchup featuring two teams trending upward in the NL Central. St. Louis has won 7 of its last 10 and continues to surge behind strong pitching and timely hitting, while Cincinnati has clawed back above .500 thanks to improved rotation stability and a rejuvenated offense. Sunday’s finale features Matthew Liberatore against Brady Singer, a matchup that could tilt toward offense in a hitter-friendly ballpark.

Venue & Weather

Great American Ball Park — Cincinnati, OH

Weather Forecast (May 24):

  • Temperature: 78–82°F
  • Wind: 8–12 mph out to right-center
  • Humidity: 60%
  • Rain: <10%
  • Impact:
    • Warm air + wind out = boost for left-handed power hitters
    • One of MLB’s top HR parks → expect scoring opportunities
    • Pitchers who rely on fly-ball outs are at risk

Injury Report

St. Louis Cardinals

  • Nolan Arenado — Day-to-day (back stiffness)
  • Willson Contreras — OUT (forearm)
  • Tommy Edman — Active
  • Lars Nootbaar — Active
  • Steven Matz — OUT (shoulder)

Cincinnati Reds

  • Elly De La Cruz — Active
  • Christian Encarnacion-Strand — OUT (wrist)
  • TJ Friedl — Day-to-day (hamstring)
  • Nick Lodolo — OUT (forearm)
  • Alexis Díaz — Active

Team Records & Recent Form

St. Louis Cardinals (29–21)

  • Last 10: 7–3
  • Trend: Pitching stabilizing, offense improving
  • Strength: Balanced lineup, strong bullpen
  • Weakness: Middle-of-order depth without Contreras

Cincinnati Reds (26–25)

  • Last 10: 6–4
  • Trend: Offense heating up, rotation competitive
  • Strength: Speed, power, aggressive baserunning
  • Weakness: Bullpen inconsistency

Probable Pitching Matchup

St. Louis — LHP Matthew Liberatore (3–3, 4.22 ERA)

  • Profile:
    • Curveball-heavy lefty
    • Generates ground balls when sharp
    • Command can fluctuate
  • Splits:
    • Vs RHB: .268 AVG
    • Vs LHB: .241 AVG
    • Road ERA: 4.60
  • Matchup Notes:
    • Reds’ right-handed bats (India, Stephenson, De La Cruz from right side) are key
    • Fly-ball tendencies could be punished in Cincinnati

Cincinnati — RHP Brady Singer (4–3, 3.71 ERA)

  • Profile:
    • Sinker/slider specialist
    • Generates weak contact when locating
    • Struggles when forced up in the zone
  • Splits:
    • Vs RHB: .244 AVG
    • Vs LHB: .262 AVG
    • Home ERA: 3.95
  • Matchup Notes:
    • Cardinals’ lefties (Nootbaar, Donovan, Gorman) match up well
    • Singer must avoid middle-in sinkers to power hitters

Key Player Matchups

1. Elly De La Cruz (CIN) vs. Matthew Liberatore

  • Elite bat speed + power
  • Liberatore must avoid hanging curveballs Advantage: Cincinnati

2. Lars Nootbaar (STL) vs. Brady Singer

  • Nootbaar crushes sinkers and thrives in hitter-friendly parks Advantage: St. Louis

3. Paul Goldschmidt (STL) vs. Singer

  • Goldschmidt has historically hit sinkerballers well
  • Singer must keep pitches low Advantage: St. Louis

4. Jonathan India (CIN) vs. Liberatore

  • India’s patience could force long innings Advantage: Even

Series History

  • 2025 Season: Cardinals won 9–4
  • 2026 Season: Cardinals lead season series 3–2 entering Sunday
  • At Great American Ball Park (last 12): St. Louis leads 7–5
  • Trend: Cardinals have consistently hit well in Cincinnati

Betting Trends

St. Louis Cardinals

  • Cardinals are 8–3 in last 11 games
  • Over is 6–2 in last 8 road games
  • St. Louis is 5–1 in Liberatore’s last 6 starts

Cincinnati Reds

  • Reds are 5–2 in last 7 home games
  • Over is 7–3 in last 10 Reds games
  • Cincinnati is 4–1 in Singer’s last 5 starts

GAME ODDS

St. Louis Cardinals           9.5

Cincinnati Reds                 – 114

Odds Courtesy of Sports Odds Direct as of Saturday, May 23, 2026

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MLB Editor
Profile: A dedicated Major League Baseball analyst with a comprehensive understanding of the sport’s strategic, statistical, and developmental layers. This columnist delivers in‑depth coverage that blends advanced metrics, scouting insight, and historical context to illuminate the trends shaping today’s game. Background: With extensive experience following MLB at both the team and league levels, the columnist has contributed to national sports outlets, digital platforms, and radio segments focused on roster construction, player evaluation, and organizational philosophy. A background in sports journalism and analytics supports a disciplined approach to breaking down performance, interpreting data, and tracking long‑term competitive cycles. Signature Coverage Areas: Game previews and pitching‑matchup analysis Advanced statistical breakdowns and sabermetric insights Prospect evaluation, farm‑system trends, and player development Trade‑deadline movement, free‑agency analysis, and front‑office strategy Historical context and postseason features Style & Approach: The writing emphasizes clarity, accuracy, and accessibility — translating complex data and tactical nuance into insights that resonate with both traditional fans and analytically minded readers. Each column reflects a commitment to balanced reporting, thoughtful evaluation, and a deep appreciation for the evolving landscape of Major League Baseball.