MLB Game Preview: St. Louis Cardinals (29-21) vs. Cincinnati Reds (26-25)

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Cincinnati Reds logo

Venue: Great American Ball Park — Cincinnati, Ohio

First Pitch: 1:40 PM ET

Broadcast: Bally Sports Midwest, Bally Sports Ohio, MLB.TV

The Cardinals and Reds close out their weekend series in a matchup featuring two teams trending upward in the NL Central. St. Louis has won 7 of its last 10 and continues to surge behind strong pitching and timely hitting, while Cincinnati has clawed back above .500 thanks to improved rotation stability and a rejuvenated offense. Sunday’s finale features Matthew Liberatore against Brady Singer, a matchup that could tilt toward offense in a hitter-friendly ballpark.

Venue & Weather

Great American Ball Park — Cincinnati, OH

Weather Forecast (May 24):

  • Temperature: 78–82°F
  • Wind: 8–12 mph out to right-center
  • Humidity: 60%
  • Rain: <10%
  • Impact:
    • Warm air + wind out = boost for left-handed power hitters
    • One of MLB’s top HR parks → expect scoring opportunities
    • Pitchers who rely on fly-ball outs are at risk

Injury Report

St. Louis Cardinals

  • Nolan Arenado — Day-to-day (back stiffness)
  • Willson Contreras — OUT (forearm)
  • Tommy Edman — Active
  • Lars Nootbaar — Active
  • Steven Matz — OUT (shoulder)

Cincinnati Reds

  • Elly De La Cruz — Active
  • Christian Encarnacion-Strand — OUT (wrist)
  • TJ Friedl — Day-to-day (hamstring)
  • Nick Lodolo — OUT (forearm)
  • Alexis Díaz — Active

Team Records & Recent Form

St. Louis Cardinals (29–21)

  • Last 10: 7–3
  • Trend: Pitching stabilizing, offense improving
  • Strength: Balanced lineup, strong bullpen
  • Weakness: Middle-of-order depth without Contreras

Cincinnati Reds (26–25)

  • Last 10: 6–4
  • Trend: Offense heating up, rotation competitive
  • Strength: Speed, power, aggressive baserunning
  • Weakness: Bullpen inconsistency

Probable Pitching Matchup

St. Louis — LHP Matthew Liberatore (3–3, 4.22 ERA)

  • Profile:
    • Curveball-heavy lefty
    • Generates ground balls when sharp
    • Command can fluctuate
  • Splits:
    • Vs RHB: .268 AVG
    • Vs LHB: .241 AVG
    • Road ERA: 4.60
  • Matchup Notes:
    • Reds’ right-handed bats (India, Stephenson, De La Cruz from right side) are key
    • Fly-ball tendencies could be punished in Cincinnati

Cincinnati — RHP Brady Singer (4–3, 3.71 ERA)

  • Profile:
    • Sinker/slider specialist
    • Generates weak contact when locating
    • Struggles when forced up in the zone
  • Splits:
    • Vs RHB: .244 AVG
    • Vs LHB: .262 AVG
    • Home ERA: 3.95
  • Matchup Notes:
    • Cardinals’ lefties (Nootbaar, Donovan, Gorman) match up well
    • Singer must avoid middle-in sinkers to power hitters

Key Player Matchups

1. Elly De La Cruz (CIN) vs. Matthew Liberatore

  • Elite bat speed + power
  • Liberatore must avoid hanging curveballs Advantage: Cincinnati

2. Lars Nootbaar (STL) vs. Brady Singer

  • Nootbaar crushes sinkers and thrives in hitter-friendly parks Advantage: St. Louis

3. Paul Goldschmidt (STL) vs. Singer

  • Goldschmidt has historically hit sinkerballers well
  • Singer must keep pitches low Advantage: St. Louis

4. Jonathan India (CIN) vs. Liberatore

  • India’s patience could force long innings Advantage: Even

Series History

  • 2025 Season: Cardinals won 9–4
  • 2026 Season: Cardinals lead season series 3–2 entering Sunday
  • At Great American Ball Park (last 12): St. Louis leads 7–5
  • Trend: Cardinals have consistently hit well in Cincinnati

Betting Trends

St. Louis Cardinals

  • Cardinals are 8–3 in last 11 games
  • Over is 6–2 in last 8 road games
  • St. Louis is 5–1 in Liberatore’s last 6 starts

Cincinnati Reds

  • Reds are 5–2 in last 7 home games
  • Over is 7–3 in last 10 Reds games
  • Cincinnati is 4–1 in Singer’s last 5 starts

GAME ODDS

St. Louis Cardinals           9.5

Cincinnati Reds                 – 114

Odds Courtesy of Sports Odds Direct as of Saturday, May 23, 2026