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MLB Game Preview: St. Louis Cardinals (20-19) vs. Washington Nationals (17-22)

Game Details

  • Date: Saturday, May 10, 2025
  • Time: 4:05 PM ET
  • Venue: Nationals Park, Washington, D.C.
  • Broadcast: Bally Sports Midwest, MASN

The St. Louis Cardinals (20-19) take on the Washington Nationals (17-22) in the second game of a three-game series at Nationals Park. The Cardinals enter the matchup riding a five-game winning streak, while the Nationals look to bounce back after dropping their last contest.

Team Form & Key Storylines

Cardinals’ Hot Streak

St. Louis has been one of the hottest teams in baseball, securing five consecutive wins, including series victories over the New York Mets and Pittsburgh Pirates. Their offense has been clicking, ranking first in MLB with a .260 batting average and sixth in on-base percentage (.334).

Nationals’ Struggles

Washington has been inconsistent, struggling to string together wins. Their offense ranks 14th in runs scored (168) and 17th in home runs (38), while their pitching staff has posted a 5.37 ERA (27th in MLB).

Head-to-Head History

This is the second meeting of the season between these teams. The Cardinals took the series opener, but Washington has shown the ability to compete against top teams, securing series wins against the Dodgers and Diamondbacks earlier this season.

Key Matchups to Watch

Brendan Donovan vs. Nationals Pitching

Donovan has been one of the Cardinals’ most consistent hitters, boasting a .331 batting average and a .468 slugging percentage. His ability to get on base and drive in runs will be crucial for St. Louis.

James Wood vs. Cardinals Pitching

Wood has been Washington’s offensive leader, hitting .281 with a .555 slugging percentage. If he can find success against St. Louis’ pitching staff, the Nationals could generate much-needed offense.

Starting Pitchers: Andre Pallante vs. Trevor Williams

  • Cardinals:Andre Pallante (2-2, 4.75 ERA, 21 strikeouts in 36.2 innings)
    • Pallante has struggled with consistency, allowing nine hits and four earned runs in his last outing.
  • Nationals: Trevor Williams (2-3, 5.86 ERA, 30 strikeouts in 36 innings)
  • Williams has had difficulty maintaining control, giving up nine runs and 14 hits over his last two starts.

Game Odds

St. Louis Cardinals           – 115

Washington Nationals   9

Odds Courtesy of Sports Odds Direct as of Friday, May 9, 2025

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