MLB Game Preview: San Francisco Giants (6-11) vs. Cincinnati Reds (10-7)

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Cincinnati Reds logo

First Pitch: 6:40 PM EDT Venue: Great American Ball Park, Cincinnati, Ohio

Weather Outlook (Contextual Inference)

No direct weather data was provided in the sourced material. Mid‑April evenings in Cincinnati typically feature cool temperatures and light winds. This is an inference based on seasonal norms, not a sourced forecast.

Starting Pitching Matchup

San Francisco Giants — RHP Tyler Mahle

Record: 0–2

ERA: 4.30

WHIP: 1.57

Strikeouts: 15 Mahle is coming off a strong outing (5 shutout innings, 6 K vs. Philadelphia).

Cincinnati Reds — RHP Rhett Lowder

Record: 1–1

ERA: 3.31

WHIP: 1.22

Strikeouts: 11 Lowder has allowed just one home run across his first 47 MLB innings.

Team Records & Recent Form

Cincinnati Reds (10–7)

Home Record: 5–5**

Last 10 Games: 6–4

Team BA: .202 (last 10)

Team ERA: 3.74 (last 10)

Run Differential: –8 (last 10)

Season Strength: 6th‑best ERA in NL (3.86)

San Francisco Giants (6–11)

Road Record: 3–4

Last 10 Games: 3–7

Team BA: .251 (last 10)

Team ERA: 4.66 (last 10)

Run Differential: –16 (last 10)

Season Offense: 3.2 runs/game (29th in MLB)

Injury Report

Cincinnati Reds

Jose Trevino — 10‑day IL (back)

Caleb Ferguson — 15‑day IL (oblique)

Hunter Greene — 60‑day IL (elbow)

Nick Lodolo — 15‑day IL (finger)

San Francisco Giants

Jose Butto — 15‑day IL (arm)

Reiver Sanmartin — 60‑day IL (hip)

Joel Peguero — 15‑day IL (hamstring)

Sam Hentges — 15‑day IL (shoulder)

Hayden Birdsong — 60‑day IL (forearm)

Jason Foley — 60‑day IL (shoulder)

Randy Rodriguez — 60‑day IL (elbow)

Rowan Wick — 60‑day IL (elbow)

Key Player Matchups

Cincinnati Reds

Sal Stewart: 4 doubles, 5 HR, 11 RBI — major power threat.

Spencer Steer: 9‑for‑37, 3 HR over last 10 games.

San Francisco Giants

Willy Adames: Team‑leading 3 HR, .545 SLG.

Casey Schmitt: 14‑for‑35, HR, 4 RBI over last 10 games.

Series History & Context

This is the second meeting of the season.

Giants enter on a three‑game losing streak.

Reds won the previous night behind HRs from Spencer Steer and Sal Stewart.

Betting Trends

Why Cincinnati may win/cover:

Reds have covered the run line in 6 of their last 7 as home underdogs vs. NL West.

Reds have led after 3 and 5 innings in three straight vs. Giants.

Why San Francisco may win/cover:

Giants have won six straight as road favorites vs. Reds.

Giants have covered eight straight vs. NL Central after a road loss.

Game Odds

San Francisco Giants      – 115

Cincinnati Reds                 9

Odds Courtesy of Sports Odds Direct as of Tuesday, April 14, 2026