Progressive Field, Cleveland, Ohio.
First pitch: 7:10 p.m. ET.
TV/streaming: CleGuardians.TV and Padres.TV (via Fubo).
This is Game 2 of a three-game interleague series. The Padres won the opener 7-5 on Friday, rallying from a 3-0 deficit behind home runs from Xander Bogaerts (two-run) and Fernando Tatis Jr. (solo), plus three RBIs from Luis Campusano. Michael King earned the win. San Diego has won six straight and 16 of its last 20, sitting second in the NL West and holding a wild-card spot. Cleveland has struggled recently (2-8 in last 10, multiple home losses) and sits fourth in the AL Central.
Starting Pitchers
Padres: LHP Wandy Peralta (2-2, 3.39 ERA, 1.38 WHIP, ~61 IP). Expected to open/serve as the starter (or bulk role in some reports); solid numbers in limited work this season with good control relative to workload.
Guardians: LHP Joey Cantillo (8-7, 3.91 ERA, 1.48 WHIP, 119.2 IP, 132 K, 56 BB in 25 starts). Workhorse starter with strong K rate but elevated WHIP and walks. Recent outings mixed (rain-shortened vs. White Sox; multi-run allowances earlier). Limited prior H2H vs. Padres.
Both lefties create a same-side matchup. Cantillo has more volume and experience as a full-time starter; Peralta’s lower ERA offers upside in a potentially shorter outing.
Probable/Approximate Key Roster Notes
Padres (key contributors): Fernando Tatis Jr. (.280 AVG, power/speed), Manny Machado (23 HR, RBI leader), Jackson Merrill, Xander Bogaerts (recent multi-HR stretch), Ty France, Luis Campusano (hot recently with multi-RBI games), Jake Cronenworth, others. Balanced offense with timely power and contact on the current hot streak.
Guardians (key contributors): Chase DeLauter (strong AVG/SLG, RBI production), José Ramírez (returning to lineup after planned rest post-hamate injury), Brayan Rocchio (recent HR), Nathaniel Lowe (multi-hit games), Steven Kwan, Jo Adell, others. Contact-oriented but lower power overall (fewest HR range in some rankings).
Injury Reports
Padres: Miguel Andujar (10-day IL, wrist), Samad Taylor (10-day, oblique), Lucas Giolito (15-day, elbow), Jason Adam (60-day, shoulder), Joe Musgrove (60-day, elbow), Bryan Hoeing (60-day, elbow), Ramon Laureano (60-day, hip), Nick Pivetta (60-day, elbow). Notable pitching and depth absences.
Guardians: Slade Cecconi (15-day IL, arm), Shawn Armstrong (60-day, leg). Relatively lighter IL list focused on pitching.
Weather Forecast
Progressive Field: Mostly cloudy, highs in the mid-80s°F (around 80–84°F), light south/southeast winds (~5 mph). Chance of showers or thunderstorms increasing later in the evening/overnight (60–70% range after midnight into Sunday). Humid conditions possible. Generally playable for a night game with low early rain risk, but monitor for delays.
Recent Team Forms
Padres: Excellent (8-2 last 10; 6-game win streak; 16-4 in last 20). Stronger offense and pitching of late (.279 AVG, 3.46 ERA in recent stretch). Road record 29-31.
Guardians: Poor (2-8 last 10; struggling at home with a multi-game skid). Team ERA solid overall (~3.86) but recent results lag (outscored in the stretch). Home record 28-32.
Series History (2026 and recent)
Padres lead this series 1-0 after Friday’s comeback win. Limited 2026 meetings (second overall). Prior interleague results competitive but sparse in recent years.
Key Player vs. Player / Matchup Notes
Peralta (LHP) vs. Guardians order (DeLauter contact/power, Ramírez switch/all-around, Rocchio, Lowe, Kwan contact): Left-on-left challenges; Guardians’ lefty-heavy or contact approach could test Peralta’s command.
Cantillo (LHP, high-K potential) vs. Padres bats (Tatis Jr. elite tools, Machado power, Merrill, Bogaerts recent hot streak, France, Campusano): Same-side lefty matchup favors pitchers somewhat, but San Diego’s current form and right-handed power threats (Machado et al.) pose risks. Cantillo’s walk rate elevates free-pass danger against disciplined hitters.
Broader: Padres’ momentum and bullpen depth vs. Guardians’ home park and need to snap skid. Baserunning (both teams active) and defense factor. Ramírez’s return boosts Cleveland’s lineup.
Betting Trends
Padres’ elite recent form and win streak vs. Guardians’ home struggles and poor last-10. Left-on-left starters may suppress scoring. Lean to Padres due to momentum; value on underdogs or Unders possible. Friday went Over in a higher-scoring affair.
Game Odds
San Diego Padres 8.5
Cleveland Guardians – 118
Odds Courtesy of Sports Odds Direct as of Friday, August 14, 2026
