The San Diego Padres (16-6) and Detroit Tigers (13-9) are set to open a three-game interleague series on Monday, April 21, 2025, at Comerica Park in Detroit. Both teams enter the matchup as division leaders, making this a compelling battle between two strong contenders.

Game Details
- Date: Monday, April 21, 2025
- Time: 6:40 PM ET
- Venue: Comerica Park, Detroit
- TV Broadcast: Bally Sports Detroit, Bally Sports San Diego
- Series Status: Game 1 of 3
Team Overview & Key Players
San Diego Padres (16-6, 1st in NL West)
The Padres have been one of the most dominant teams in the National League, leading MLB with a .346 team on-base percentage. Their pitching staff has also been elite, ranking second in MLB with a 2.74 ERA.
Key Players
- Fernando Tatis Jr. (RF) – Leads the team with eight home runs and 10 extra-base hits.
- Manny Machado (3B) – A consistent force at the plate, hitting .275 with five home runs.
- Luis Arraez (1B) – Batting .274 with two home runs over his last 10 games.
- Randy Vasquez (SP) – Set to start; holds a 1-1 record with a 1.74 ERA.
Detroit Tigers (13-9, 1st in AL Central)
The Tigers have been strong at home, boasting an 8-2 record at Comerica Park. Their offense ranks 11th in MLB with a .246 team batting average, while their pitching staff has a 2.66 ERA over the last 10 games.
Key Players
- Spencer Torkelson (1B) – Leads Detroit with seven home runs and 21 RBIs.
- Kerry Carpenter (OF) – Batting .288 with two doubles and a home run over his last 10 games.
- Keider Montero (SP) – Set to start; holds a 0-1 record with a 9.00 ERA.
Game 1 Pitching Matchup
Pitcher | Team | Record | ERA | Last Start |
---|---|---|---|---|
Randy Vasquez | Padres | 1-1 | 1.74 | 5.0 IP, 1 ER vs. Cubs |
Keider Montero | Tigers | 0-1 | 9.00 | 5.0 IP, 5 ER vs. Brewers |
Vasquez has been solid in his first few starts, while Montero is looking to bounce back from a rough outing against Milwaukee.
Game Outlook & Predictions
- Padres’ Strategy: Expect San Diego to rely on power hitting, with Tatis Jr. and Machado leading the charge.
- Tigers’ Adjustments: Detroit must limit home runs and capitalize on scoring opportunities against Vasquez.
- X-Factor: Spencer Torkelson’s ability to drive in runs could be the difference-maker.
Game Odds
San Diego Padres 8
Detroit Tigers – 130
Odds Courtesy of Sports Odds Direct as of Sunday, April 20, 2025