The San Diego Padres and Houston Astros are set to face off in an exciting MLB regular-season matchup on April 20, 2025, at Daikin Park in Houston, Texas. This game marks the final contest in a three-game interleague series, with the Astros looking to complete a sweep.

Game Details
- Date: April 20, 2025
- Time: 7:10 PM ET
- Venue: Daikin Park, Houston
- Season Phase: Regular Season
Team Performance & Key Players
Houston Astros
The Astros have been building momentum, securing back-to-back wins for the first time this season. Christian Walker played a pivotal role in Saturday’s victory, hitting a two-run homer in the sixth inning to tie the game. Isaac Paredes followed up with a game-winning RBI single in the seventh, sealing a 3-2 win for Houston. The Astros have struggled offensively, scoring three or fewer runs in four of their last five games, but their pitching staff has been solid, conceding four or fewer runs in seven of their last eight outings.
San Diego Padres
The Padres remain atop the NL West standings, despite dropping the first two games of the series. Fernando Tatis Jr. has been a standout performer, hitting a solo home run in the third inning of Saturday’s game. Manny Machado also contributed offensively, driving in a run with a deep right-field double in the fifth inning. San Diego’s pitching has been effective, holding opponents to four runs or fewer in five of their last six road games.
Pitching Matchup
Houston will send Framber Valdez (1-2, 4.91 ERA) to the mound. Valdez has struggled in his last outing, allowing seven earned runs over four innings against St. Louis. San Diego will counter with Dylan Cease (1-1, 6.64 ERA), who has a 1.52 WHIP and has struck out 24 batters in 20 1/3 innings.
Game Odds
San Diego Padres 7.5
Houston Astros – 125
Odds Courtesy of Sports Odds Direct as of Saturday, April 19, 2025