MLB Game Preview: Pittsburgh Pirates (12-24) vs. St. Louis Cardinals (17-19)

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St. Louis Cardinals logo

Date: May 7, 2025
Time: 1:15 PM ET
Venue: Busch Stadium, St. Louis, MO
Broadcast: Bally Sports Midwest, SportsNet Pittsburgh

Matchup Overview

The Pittsburgh Pirates (12-24) and St. Louis Cardinals (17-19) meet for the final game of their three-game series at Busch Stadium. The Cardinals have won three straight games, while the Pirates are struggling, having lost eight of their last nine.

The season series is currently tied 2-2, making this a pivotal matchup for both teams.

Starting Pitchers

Pittsburgh Pirates – Mitch Keller (1-3, 4.38 ERA, 39 K)

  • Last Start: 6 innings, 2 earned runs vs. Milwaukee.
  • Season Stats: 4.38 ERA, 1.32 WHIP, .252 opponent batting average.
  • Analysis: Keller has been solid but inconsistent, struggling with command at times. He’ll need to limit hard contact against St. Louis’ lineup.

St. Louis Cardinals – Sonny Gray (3-1, 4.12 ERA, 39 K)

  • Last Start: 4 1/3 innings, 4 earned runs vs. New York Mets.
  • Season Stats: 4.12 ERA, 1.19 WHIP, .252 opponent batting average.
  • Analysis: Gray has been effective but vulnerable, allowing nine hits in his last outing. He’ll look to bounce back against a Pirates offense that ranks 27th in MLB in runs scored (117).

Key Players to Watch

Pittsburgh Pirates

  • Oneil Cruz – Had a 35-game stolen base streak snapped in Game 1.
  • Bryan Reynolds – Batting .268 with six home runs.
  • Ke’Bryan Hayes – Provides defensive stability but needs to improve offensively.

St. Louis Cardinals

  • Willson Contreras – Batting .455 over his last six games, with three home runs and 10 RBIs.
  • Masyn Winn – A rising star, contributing both offensively and defensively.
  • Brendan Donovan – A key piece in the Cardinals’ lineup, looking to capitalize against Keller.

Game Storylines & Predictions

1. Can Pittsburgh’s Offense Break Through?

The Pirates rank 27th in MLB in runs scored and 29th in slugging percentage (.335). They’ll need a strong offensive showing to challenge Gray.

2. Cardinals’ Home Advantage

St. Louis has been dominant at home (13-6 record), showing strength at Busch Stadium.

3. Pitching Duel – Keller vs. Gray

Both starters have had inconsistent seasons, making this a potential high-scoring affair.

Game Odds

Pittsburgh Pirates            7.5

St. Louis Cardinals           – 180

Odds Courtesy of Sports Odds Direct as of Tuesday, May 6, 2025