MLB Game Preview: New York Yankees (14-9) vs. Cleveland Guardians (13-9)

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Cleveland Guardians logo

The New York Yankees (14-9) and Cleveland Guardians (13-9) are set to face off in the second game of their four-game series on Tuesday, April 22, 2025, at Progressive Field in Cleveland. The Guardians enter the matchup riding a four-game winning streak, having defeated the Yankees 6-4 in the series opener on Monday.

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Game Details

  • Date: Tuesday, April 22, 2025
  • Time: 6:10 PM ET
  • Venue: Progressive Field, Cleveland
  • TV Broadcast: YES Network, Bally Sports Great Lakes
  • Series Status: Guardians lead 1-0

Team Overview & Key Players

Cleveland Guardians (13-9, 2nd in AL Central)

The Guardians have been red-hot, winning 10 of their last 13 games and boasting a 6-1 home record. Their offense has been efficient, ranking 10th in MLB with 28 home runs.

Key Players

  • José Ramírez (3B) – Leads the Guardians with four home runs, looking to break out offensively.
  • Steven Kwan (OF) – Has been a consistent presence at the plate, hitting .290 with four home runs.
  • Tanner Bibee (SP) – Set to start; holds a 1-2 record with a 5.85 ERA and 20 strikeouts in 20 innings.

New York Yankees (14-9, 1st in AL East)

The Yankees have been strong offensively, ranking second in MLB in total runs scored (130) and leading the league with 40 home runs. However, they have lost two of their last three games and need a bounce-back performance.

Key Players

  • Aaron Judge (OF) – Has reached base in 19 straight games, with four doubles, three home runs, and 14 RBIs.
  • Anthony Volpe (SS) – Batting .258, providing solid production at the top of the lineup.
  • Will Warren (SP) – Set to start; holds a 1-0 record with a 5.17 ERA and 16 strikeouts in 15.2 innings.

Game 2 Pitching Matchup

PitcherTeamRecordERALast Start
Tanner BibeeGuardians1-25.855.2 IP, 6 ER vs. Twins
Will WarrenYankees1-05.171.2 IP, 1 ER vs. Rays

Bibee has struggled in recent outings, while Warren is looking to bounce back after a short start against Tampa Bay.

Game Outlook & Predictions

  • Guardians’ Strategy: Expect Cleveland to rely on early offense, using Ramírez and Kwan to set the tone.
  • Yankees’ Adjustments: New York must capitalize on scoring opportunities and limit strikeouts against Bibee.
  • X-Factor: Aaron Judge’s ability to drive in runs could be the difference-maker.

Game Odds

New York Yankees                           – 112

Cleveland Guardians                      8

Odds Courtesy of Sports Odds Direct as of Monday, April 21, 2025