MLB Game Preview: Cincinnati Reds (20-15) vs. Chicago Cubs (23-12)

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Chicago Cubs logo

Venue: Wrigley Field — Chicago, Illinois

First Pitch: 7:40 PM ET / 6:40 PM CT

Surface: Natural grass

Series: Game 2 of 3

The Cubs enter with one of MLB’s best records and a dominant home profile. Cincinnati, meanwhile, is trying to rebound after dropping the series opener and stabilize its rotation.

WEATHER REPORT (Chicago — Evening)

Temperature: 57–60°F

Wind: 14–18 mph blowing out to left‑center

Humidity: Moderate

Rain: <10% chance

Impact:

Significant boost to right‑handed power hitters

Wrigley becomes a hitter‑friendly park when winds blow out

Pitchers must keep the ball down or risk multi‑run innings

INJURY REPORT

Cincinnati Reds

Hunter Greene (shoulder) — OUT

TJ Friedl (oblique) — OUT

Christian Encarnacion‑Strand (wrist) — Day‑to‑day

Nick Lodolo (back) — Expected to return soon but not available

Alexis Díaz (fatigue) — Available but monitored

Chicago Cubs

Seiya Suzuki (hamstring) — OUT

Justin Steele (forearm) — OUT

Jameson Taillon (back) — Day‑to‑day

Nico Hoerner (ankle) — Expected to play

Adbert Alzolay (elbow) — OUT

PROBABLE STARTING PITCHERS

Reds — RHP Graham Ashcraft (2–3, 4.88 ERA)

Heavy cutter/sinker profile

Struggles vs. left‑handed hitters

Road ERA: 5.40

Has allowed 4+ runs in 3 of last 4 starts

Fly‑ball vulnerability is a concern with wind blowing out

Cubs — RHP Javier Assad (3–1, 2.91 ERA)

Elite soft‑contact generator

Home ERA: 2.55

Excellent command; rarely gives up big innings

Reds’ aggressive approach plays into his strengths

TEAM RECORDS & RECENT FORM

Cincinnati Reds

Record: 20–15

Last 10: 4–6

Road record: 9–9

Offense: 4.6 runs/game

Trend: Pitching regression; bullpen overworked

Chicago Cubs

Record: 23–12

Last 10: 7–3

Home record: 13–5

Offense: 4.9 runs/game

Trend: Balanced lineup + strong bullpen + elite home performance

SERIES HISTORY

2023–2026 combined: Cubs lead 25–20

At Wrigley Field: Cubs have won 8 of last 11

Cubs won the opener of this series (May 4, 2026)

KEY PLAYER MATCHUPS

1. Elly De La Cruz vs. Javier Assad

Elly’s power/speed combo is always a threat, but Assad’s command and ability to avoid barrels make this a difficult matchup.

2. Cody Bellinger vs. Graham Ashcraft

Bellinger thrives vs. sinker/cutter pitchers and gets a major boost from the wind blowing out.

3. Spencer Steer vs. Cubs bullpen

Steer’s late‑inning production is crucial for Cincinnati, especially with Díaz not fully rested.

BETTING TRENDS

Cincinnati Reds

3–7 in last 10 road games

Over has hit in 6 of last 8

Reds are 2–6 in last eight vs. Cubs

Chicago Cubs

7–1 in last eight home games

Cubs are 10–3 in last 13 overall

Over is 5–2 in last seven at Wrigley with wind blowing out

Game Odds

Cincinnati Reds                 8

Chicago Cubs                     – 168

Odds Courtesy of Sports Odds Direct as of Monday, May 4, 2026