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MLB Game Preview: Cincinnati Reds (19-21) vs. Houston Astros (19-18)

Game Details

  • Date: Saturday, May 10, 2025
  • Time: 7:10 PM ET
  • Venue: Daikin Park, Houston, TX
  • Broadcast: ESPN, Bally Sports Ohio, AT&T SportsNet Southwest

The Cincinnati Reds (19-21) take on the Houston Astros (19-18) in the second game of a three-game series at Daikin Park. The Astros hold a 1-0 series lead after securing a 3-0 victory in the opener, snapping Cincinnati’s nine-game winning streak against Houston. The Reds will look to bounce back, while the Astros aim to build momentum at home.

Team Form & Key Storylines

Astros’ Pitching Dominance

Houston’s pitching staff has been one of the best in MLB, holding opponents to a .216 batting average, ranking second in the league. Their ability to limit scoring opportunities has been a key factor in their success.

Reds’ Offensive Struggles

Cincinnati’s offense has been inconsistent, ranking seventh in MLB with 185 runs scored but struggling in the series opener, managing just two hits against Houston’s pitching. The Reds need a strong offensive performance to avoid falling further behind in the series.

Head-to-Head History

Before Friday’s loss, Cincinnati had swept their last three series against Houston (2019, 2023, 2024). The Astros’ victory marked their first win over the Reds since June 19, 2016.

Key Matchups to Watch

Lance McCullers vs. Reds’ Lineup

McCullers will make his second start of the season, having pitched 3 2/3 scoreless innings in his debut against the White Sox. His ability to control the strike zone will be crucial against Cincinnati’s hitters.

Brady Singer vs. Astros’ Offense

Singer has been solid for Cincinnati, holding a 4-2 record. He will need to contain Houston’s lineup, which has struggled with power, ranking 22nd in MLB with 31 home runs.

Oneil Cruz vs. Astros Pitching

Cruz has been Cincinnati’s top slugger, leading the team with eight home runs and a .476 slugging percentage. His ability to generate offense will be key for the Reds.

Game Odds

Cincinnati Reds                 8

Houston Astros                 – 135

Odds Courtesy of Sports Odds Direct as of Friday, May 9, 2025

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