The Baltimore Orioles (9-12) and Washington Nationals (9-13) are set to face off in the series opener on Tuesday, April 22, 2025, at Nationals Park in Washington, D.C.. Both teams are looking to gain momentum after inconsistent starts to the season.

Game Details
- Date: Tuesday, April 22, 2025
- Time: 6:45 PM ET
- Venue: Nationals Park, Washington, D.C.
- TV Broadcast: MASN, MASN2
- Series Status: First meeting of the season
Team Overview & Key Players
Washington Nationals (9-13, 5th in NL East)
The Nationals have struggled with consistency, ranking 22nd in MLB in slugging percentage (.368) and 18th in total runs scored (93). Their pitching staff has been shaky, posting a 5.79 ERA over the last 10 games.
Key Players
- Keibert Ruiz (C) – Batting .306 with two home runs and 11 RBIs.
- James Wood (OF) – Leads the team with seven home runs and 17 RBIs.
- Mitchell Parker (SP) – Set to start; holds a 2-1 record with a 4.50 ERA.
Baltimore Orioles (9-12, 4th in AL East)
The Orioles have been solid offensively, ranking sixth in MLB with 31 home runs and 12th in total runs scored (98). However, their pitching has been inconsistent, with a 6.88 ERA over the last 10 games.
Key Players
- Adley Rutschman (C) – Has four home runs and seven RBIs, but is batting just .208.
- Gunnar Henderson (SS) – Batting .250 with three doubles and two home runs.
- Dean Kremer (SP) – Set to start; holds a 2-2 record with a 6.41 ERA.
Game 1 Pitching Matchup
Pitcher | Team | Record | ERA | Last Start |
---|---|---|---|---|
Mitchell Parker | Nationals | 2-1 | 4.50 | 5.0 IP, 3 ER vs. Phillies |
Dean Kremer | Orioles | 2-2 | 6.41 | 5.1 IP, 1 ER vs. Guardians |
Parker has been steady, while Kremer is looking to build on his strong outing against Cleveland.
Game Outlook & Predictions
- Nationals’ Strategy: Expect Washington to rely on power hitting, with Wood and Ruiz leading the charge.
- Orioles’ Adjustments: Baltimore must capitalize on scoring opportunities and limit strikeouts against Parker.
- X-Factor: Adley Rutschman’s ability to drive in runs could be the difference-maker.
Game Odds
Baltimore Orioles – 135
Washington Nationals 9
Odds Courtesy of Sports Odds Direct as of Monday, April 21, 2025