Venue & Event Details
Location: Autzen Stadium, Eugene, OR
Kickoff: 7:30 PM EST / 4:30 PM PST
Broadcast: ABC/ESPN
Weather Forecast
Temperature: 48°F at kickoff, dropping into low 40s by evening
Conditions: Cloudy skies, light rain possible, winds 8–12 mph
Impact: Passing efficiency may be challenged; rushing and ball control favored
Injury Report
USC: QB Jayden Maiava (healthy, 2,400+ yards, 21 TDs); WR corps intact, RB rotation healthy.
Oregon: QB Dante Moore (healthy, 2,600+ yards, 25 TDs, 3rd nationally in passer rating); WR Makai Lemon (probable, back-to-back 10+ reception games, FBS leader in consecutive high-reception streaks).
Key Player Matchups
Dante Moore (Oregon QB) vs USC Secondary: Moore’s efficiency and rhythm passing will test a defense that has struggled against elite QBs.
Makai Lemon (Oregon WR) vs USC CBs: Lemon’s reliability in short and intermediate routes could dictate tempo.
Jayden Maiava (USC QB) vs Oregon Defense: USC’s late-game resilience (6th nationally in 4th-quarter point differential, +5.7) will hinge on Maiava’s ability to execute under pressure.
Recent Team Forms
USC: Won 3 straight, including 31–24 vs Washington; offense trending upward, defense inconsistent.
Oregon: Won 5 straight, including 45–21 vs UCLA; only loss came to Indiana earlier in season.
Series History
Oregon leads the all-time series 26–21.
Ducks have won 4 of last 6 meetings.
USC last beat Oregon in 2020 (Pac-12 Championship).
Betting Trends:
Oregon is 7–3 ATS this season.
USC is 6–4 ATS.
Overs have hit in 3 of last 5 Oregon games.
Historical Betting Results
Oregon has covered in 5 of last 7 home games.
USC has covered in 4 of last 6 road games.
Oregon has won 8 of last 10 games at Autzen vs USC.
Prediction: Oregon 34 – USC 27
Game Odds
USC Trojans 58.5
Oregon Ducks – 10.5
Odds Courtesy of Sports Odd Direct as of Friday, November 21, 2025
