High/Low: 33°F / 30°F
Conditions: Rain and snow mix, gusty winds up to 27 mph
Precipitation: 74% chance, with ~1.4 inches of snow possible
Impact: Passing games could be limited; ground attack and turnovers loom large
Injury Report
49ers:
WR Brandon Aiyuk (knee – PUP) – OUT
DE Nick Bosa (ACL) – OUT
LB Fred Warner (ankle – IR) – OUT
WR Jacob Cowing (hamstring – IR) – OUT
DE Sam Okuayinonu (groin) – Questionable
LB Tatum Bethune (ankle) – Questionable
K Eddy Pineiro (hamstring) – Questionable
Browns:
QB Deshaun Watson (Achilles – PUP) – OUT
CB Martin Emerson (Achilles – IR) – OUT
WR Jamari Thrash (foot) – Questionable
DE Alex Wright (quad) – OUT
DT Adin Huntington (groin) – Questionable
Team Recent Form
San Francisco 49ers: Won 2 straight, including a 20–9 victory over Carolina. Strong passing offense (ranked 3rd).
Cleveland Browns: Snapped losing streak with 24–10 win vs Raiders. Rookie QB Shedeur Sanders won his debut.
Player Matchups
QB Battle: Brock Purdy vs Shedeur Sanders. Purdy has struggled in bad weather historically, while Sanders faces his toughest test yet.
RB Clash: Christian McCaffrey (NFL-leading 1,581 scrimmage yds, 12 TDs) vs Browns’ elite run defense.
Defensive Spotlight: Myles Garrett (league-leading 18 sacks, 14 in last 5 games) vs 49ers’ O-line.
Receiving Threats: George Kittle (229 yds, 3 TDs in last 3 games) vs Browns linebackers.
Series History
All-time: Browns lead 13–8
Recent: Browns won last meeting 19–17 (Oct 15, 2023).
Trend: Home team has won last 5 meetings; 49ers haven’t won in Cleveland since 1984.
Betting Trends
ATS Records: 49ers 7–5; Browns 5–6
Totals: 49ers OVER 7–4–1; Browns OVER 6–5
Trend: Browns 4–1 ATS at home; 49ers 5–2 ATS on road
Bottom Line: Expect a gritty, weather-impacted AFC-NFC clash. The 49ers’ balanced attack and McCaffrey’s versatility give them the edge, but Cleveland’s defense and Garrett’s historic sack pace make this a dangerous spot for San Francisco.
49ERS NOTES:
• QB BROCK PURDY completed 23 of 32 att. (71.9 pct) for 193 yards & TD in Week 12. Has 200+ pass yards in 3 of his 4 starts this season. Has TD pass in every game played this season. Aims for 3rd in row on road with 90+ rating. Had pass TD in last meeting. • RB CHRISTIAN MCCAFFREY had 142 scrimmage yards (89 rush, 53 rec.) & rush TD in Week 12, his 10th game this season with 100+ scrimmage yards, most in the NFL. Is 1 of 3 RBs all-time (Larry Centers & HOFer Marshall Faulk) with 50+ games (50) with 50+ rec. yards. Has scrimmage TD in 5 of his past 6 games on road. Had rec. TD in last meeting. Ranks 1st in NFL with 1,581 scrimmage yards & 81 receptions in 2025. • WR JAUAN JENNINGS had rec. TD in Week 12 & had rec. TD in 3 of his past 4. Aims for 6th in row with 40+ rec. yards. • TE GEORGE KITTLE led team with 78 rec. yards last week. Is 5th TE in NFL history with 7,500+ rec. yards & 50+ rec. TDs in 1st 9 seasons. Ranks tied-5th among TEs with 5 rec. TDs in 2025. Ranks 2nd in NFL among TEs with 571 receptions & 7,709 rec. yards & 3rd with 50 rec. TDs since 2017. • LB DEE WINTERS has TFL in 2 of his past 3 & has career-high 6 TFL this season. Has 5+ tackles in 4 of his past 5. • LB TATUM BETHUNE has 10+ tackles in 5 of his past 6 games. • DE CLELIN FERRELL had 2nd sack this season in Week 12. • CB UPTON STOUT (rookie) had 6 tackles & PD last week. Aims for 7th in row on road with 5+ tackles. • CB DEOMMODORE LENOIR had 5 tackles & INT in last meeting. • S JI’AYIR BROWN had 1st career game with 2 INTs in Week 12.. Has PD in 3 of his past 4 games. • S MALIK MUSTAPHA led team with 7 tackles & TFL last week. Has 5+ tackles in 5 of his past 6.
BROWNS NOTES:
• QB SHEDEUR SANDERS (rookie) passed for 209 yards & TD in 1st-career NFL start in Week 12. • RB DYLAN SAMPSON (rookie) led team with 82 scrimmage yards (59 rec., 23 ruhs) & had TD catch last week. • RB QUINSHON JUDKINS had 47 rush yards & 2 rush TDs in Week 12. Ranks tied-2nd among rookies with 7 TDs in 2025 & is 1 of 3 rookies (TreVeyon Henderson & Tetairoa McMillan) with multiple games with 2+ TDs (2). Aims for his 4th in row with 45+ scrimmage yards. • WR JERRY JEUDY had 39 rec. yards last week. • WR ISAIAH BOND (rookie) had 58 rec. yards in Week 12. • TE HAROLD FANNIN JR. had 4 catches for 40 yards last week. Ranks 2nd among rookie TEs with 48 catches this season. • DE MYLES GARRETT had 3 sacks & 2 FF in Week 12, only player in NFL with multiple games (3) with 3+ sacks in 2025. Leads NFL with 18 sacks this season, 3rd player since 1982 with 16+ sacks in 3+ seasons (J.J. Watt & HOFer Reggie White). Has 0.5+ sacks in each of his 4 games at Huntington Bank Field this season. • DT MALIEK COLLINS had 2.5 sacks & 1st FR of season last week. Aims for his 4th in row with TFL. Had 33 tackles, 5 sacks & 2 FR in 17 games with SF in 2024. • LB CARSON SCHWESINGER had 10 tackles & TFL in Week 12. Has most tackles among rookies in 2025 (89). Is 1 of 3 rookies (Barrett Carter – 4 & Demetrius Knight Jr. – 3) with 3+ games (3) with 10+ tackles. Aims for his 3rd in row with 10+ tackles. • CB DENZEL WARD had 2 PD & TFL last week. Has PD in 3 of his 4 games at Huntington Bank Field this season. • CB TYSON CAMPBELL had season-high 9 tackles & 2 PD in Week 12.
Game Odds
San Francisco 49ers – 4.5
Cleveland Browns 35.5
Odds Courtesy of Sports Odd Direct as of Saturday, November 29, 2025
