Venue & Game Details
Location: FirstBank Stadium, Nashville, TN
Kickoff: 11:00 a.m. CT (ABC)
Conference: SEC inter-divisional matchup
Weather Forecast: Nashville – ~64°F at kickoff, partly cloudy, light winds 6–9 mph,
Team Recent Form
LSU Tigers:
Wins: South Carolina (20–10), Mississippi State, Florida, Grambling, Nicholls
Loss: Ole Miss
Trend: Defense has been elite, allowing just 11.8 PPG (5th nationally). Offense has been inconsistent, averaging 25.8 PPG (86th nationally).
Vanderbilt Commodores:
Wins: Kentucky, South Carolina (31–7), Wake Forest, Memphis, UConn
Loss: Alabama (30–14)
Trend: Balanced team, averaging 43.2 PPG (7th nationally) while allowing 19.3 PPG.
Injury Report
LSU:
QB Garrett Nussmeier – Probable (ankle sprain)
WR Aaron Anderson – Questionable (knee/hip/ankle issues)
RB Caden Durham – Probable (hip pointer)
DT Bernard Gooden – Questionable (collarbone bruise)
Vanderbilt:
QB Diego Pavia – Healthy, dual-threat centerpiece
RB Sedrick Alexander – Probable (minor ankle tweak)
Key Player Matchups
QB Garrett Nussmeier (LSU): 1,411 yards, 9 TDs, 5 INTs – must limit turnovers against a defense that thrives on short fields.
WR Aaron Anderson (LSU): 305 yards – if healthy, LSU’s most dynamic receiver.
QB Diego Pavia (Vandy): 1,409 yards, 14 TDs, 4 INTs, plus 352 rushing yards – dual-threat who stresses defenses.
RB Sedrick Alexander (Vandy): 76-yard TD burst vs. Alabama shows his big-play ability.
Defensive Fronts: LSU’s top-5 scoring defense vs. Vanderbilt’s top-10 scoring offense is the defining battle.
Series History
LSU leads the all-time series 10 straight wins, including a 24–17 victory in 2024.
Vanderbilt’s last win over LSU came in 1991.
Betting Trends:
LSU is 3-3 ATS this season.
Vanderbilt is 4-2 ATS.
LSU is 2-3 ATS as a road underdog under Brian Kelly.
The Under has hit in 5 of LSU’s 6 games.
Game Odds
LSU Tigers 418.5
Vanderbilt Commodores – 1.5
Odds Courtesy of Sports Odd Direct as of Friday, October 17, 2025
