D2-CFB Game Preview: Missouri Southern State Lions (2-1) vs. Central Missouri Mules (1-2)

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Venue & Game Details

Conference: Mid-America Intercollegiate Athletics Association (MIAA), NCAA Division II

Kickoff Time: 1:00 PM CT (2:00 PM ET)

Venue: Walton Stadium/Kennedy Field, Warrensburg, Missouri (Capacity ~12,000, turf surface)

Broadcast: MIAA Network / ESPN+ (regional)

Weather Forecast (Warrensburg, MO)

Temperature: ~74°F (23°C) at kickoff

Conditions: Mostly sunny, light winds (5–9 mph)

Precipitation:

Impact: Ideal football weather; no disruptions expected

Injury Report (Projected)

(Note: D-II programs rarely release official injury reports; this is based on recent availability trends)

Missouri Southern State Lions:

QB rotation intact; starter healthy after 2–1 start.

WR1 probable (hamstring).

Defensive line missing one starter (out).

Central Missouri Mules:

QB healthy, averaging 250+ YPG passing.

RB1 expected to play despite ankle soreness.

Secondary fully intact.

Key Player Matchups

MSSU QB vs. UCM Secondary
The Lions’ passing game has been efficient, but UCM’s DBs have been opportunistic in early-season contests.

UCM RB vs. MSSU Front Seven
The Mules lean on their ground game to control tempo. MSSU’s linebackers must contain early-down runs.

Special Teams
Missouri Southern has had miscues in the kicking game; Central Missouri has been consistent in field position battles.

Recent Team Form

Missouri Southern State (2025 Season so far):

Record: 2–1 overall, 0–1 MIAA

Results:

W vs Midwestern State (33–19)

W @ Southwest Baptist (38–31)

L vs Northwest Missouri State (21–14)

Strength: Balanced offense, clutch play in close games

Weakness: Defense allowed 21+ in two of three games

Central Missouri (2025 Season so far):

Record: 2–1 overall, 1–0 MIAA

Results:

W vs Missouri Western (35–24)

L @ Pittsburg State (28–17)

W vs Emporia State (31–20)

Strength: Passing game led by veteran QB

Weakness: Inconsistent run defense

Conference vs. Conference

Both teams are MIAA rivals, making this a critical conference matchup.

Missouri Southern: Trying to rebound after a tough loss to Northwest Missouri State.

Central Missouri: Looking to stay in the MIAA title hunt with a strong home performance.

Series History

All-time series: Central Missouri leads comfortably.

Recent meetings:

2024: Central Missouri 38, Missouri Southern 21

2023: Central Missouri 42, Missouri Southern 28

Trend: UCM has won the last several meetings, often by multiple scores.

Betting Trends:

Missouri Southern is 2–1 ATS this season (modeled).

Central Missouri is 2–1 ATS this season.

MSSU games have gone Over in 2 of 3 due to offensive firepower.

UCM games have gone Under in 2 of 3 due to defensive strength.

Historical Betting Results (Modeled)

2024: Central Missouri -7.5 (covered, won 38–21)

2023: Central Missouri -6.5 (covered, won 42–28)

2022: Central Missouri -4.5 (covered, won 31–20)

2021: Central Missouri -3.5 (covered, won 27–17)

Game Odds

Missouri Southern State Lions                   55

Central Missouri Mules                                 – 9

Odds Courtesy of Sports Odd Direct as of Friday, September 26, 2025