Venue & Game Details
Kickoff: 4:05 PM ET / 1:05 PM PT
Venue: State Farm Stadium, Glendale, Arizona
Broadcast: CBS: Spero Dedes, Adam Archuleta, Aditi Kinkhabwala (field reporter)
Weather Forecast (Glendale, AZ)
Kickoff Temp: ~101°F (38°C) outside
Conditions: Sunny, low humidity
Impact: Minimal — game played indoors under a retractable roof.
Injury Report
Carolina Panthers:
OT Ikem Ekwonu — Questionable
DT Tershawn Wharton — Out
LB Patrick Jones II — Questionable
CB Damarri Mathis — IR
WR Jalen Coker — IR
Arizona Cardinals:
G Will Hernandez — Questionable
LB Zaven Collins — Questionable
S Joey Blount — Questionable
LB Cody Simon — Questionable
DT Justin Jones — IR
Recent Form
Panthers: L-W-W-L-L — Offense averaging 18.0 PPG in that span.
Cardinals: W-L-W-W-L — Defense allowing 19.4 PPG in last 5.
Series History
All-Time: Panthers lead 14–6
Last Meeting: Oct. 2, 2022 — Panthers won 26-16 in Charlotte
Trend: Carolina has covered in 7 of last 8 vs. Arizona.
Key Player Matchups
QB Battle:
Bryce Young (CAR): 18/35, 154 YDS, 1 TD, 2 INT in Week 1; needs cleaner pocket presence.
Kyler Murray (ARI): Efficient in Week 1 win; dual-threat ability could stress Carolina’s linebackers.
Skill Positions:
CAR RB Chuba Hubbard vs. ARI front seven — Hubbard’s ability to sustain drives is critical.
ARI WR Marvin Harrison Jr. vs. CAR secondary — Harrison coming off strong debut; potential mismatch.
TE Trey McBride (ARI) vs. CAR linebackers — McBride’s seam routes could be a key red-zone factor.
Defensive Spotlight:
Brian Burns (CAR) vs. Paris Johnson Jr. (ARI) — Edge pressure vs. young tackle.
Betting Trends
Panthers are 7-3 ATS in last 10 games overall.
Panthers are 2-16 SU in last 18 road games.
Over is 10-3 in Panthers’ last 13 vs. NFC West.
Cardinals are 5-1 ATS in last 6 home games.
Cardinals are 6-1 ATS in last 7 vs. NFC South.
PANTHERS NOTES:
• QB BRYCE YOUNG totaled 194 yards (154 pass, 40 rush) & TD pass in Week 1, his 4th-career game with 40+ rush yards. Aims for his 6th in row on road with TD pass. Had 3 TDs (2 pass, 1 rush) vs. 0 INTs, 107.5 rating & career-high 68 rush yards in last meeting. • RB CHUBA HUBBARD led team with 89 scrimmage yards (57 rush, 32 rec.) & had 3rd-career TD catch in Week 1. Has TD in 5 of his past 6 on road. Aims for his 7th in row on road with 50+ scrimmage yards. Had 165 scrimmage yards (152 rush, 13 rec.) & 2 rush TDs in last meeting. • RB RICO DOWDLE had TD catch in his last game vs. Ari. (9/24/23 w/ Dal.). • WR TETAIROA MCMILLAN (rookie) led team in receptions (5) & rec. yards (68) in NFL debut last week. • WR HUNTER RENFROW had 7 catches for 59 yards in his only career game vs. Ari. (9/18/22 w/ LV). • S TRE’VON MOEHRIG led team with 11 tackles in Car. debut last week, his 4thcareer game with 10+ tackles. • S NICK SCOTT had 5 tackles & PD last week. • CB JAYCEE HORN had 6th-career INT last week. Has 5 PD in his past 5 on road. • CB MIKE JACKSON had 4th career game with both TFL & PD last week. Had 2 PD in last meeting. Has 5+ tackles in 4 of his past 5 vs. Ari. • LB CHRISTIAN ROZEBOOM had 8 tackles in team debut in Week 1. Has 6+ tackles in 8 of his past 9 games. • LB TREVIN WALLACE aims for his 4th in row with 5+ tackles. • LB DJ WONNUM had 1st PD of season last week. Had sack in last meeting. • DE A’SHAWN ROBINSON had 6 tackles last week. Since 2023, leads all DL with 17 games of 5+ tackles. Had 7 tackles & sack in last meeting. Aims for his 4th in row vs. Ari. with TFL.
CARDINALS NOTES:
• QB KYLER MURRAY had 201 yards (163 pass, 38 rush) & 2 TDs vs. 0 INTs for 108.8 rating in Week 1. Had 16 TDs (13 pass, 3 rush) & 103.2 rating in 9 home starts last season. Has 10 TDs (8 pass, 2 rush) in 4 career starts vs. Car. & aims for his 3rd in row vs. Car. with both pass TD & rush TD. • RB JAMES CONNER had 12th-career rec. TD in Week 1. Has 110+ scrimmage yards in 8 of his past 9 home games & aims for his 7th in row at home with 110+ scrimmage yards. Had 166 scrimmage yards (117 rush, 49 rec.) & rush TD in last meeting & has rush TD in 3 of his 4 career games vs. Car. • RB TREY BENSON rushed for career-high 69 yards in Week 1. • WR MARVIN HARRISON JR. had 5 catches for team-high 71 yards & 9thcareer rec. TD in Week 1. Aims for his 3rd in row with TD catch & 4th in row with 5+ catches & 60+ rec. yards. • TE TREY MCBRIDE had 6 catches for 61 yards last week & aims for his 4th in row with 6+ catches & 60+ rec. yards. Had 50+ rec. yards in 5 of his final 6 home games last season. His 1st career reception came vs. Car. (10/2/22). • S BUDDA BAKER led team with 10 tackles & had TFL & PD in Week 1, his 34th career game with 10+ tackles, most among DBs since 2017. Has 5+ tackles in 23 straight home games. • S JALEN THOMPSON had 10 tackles in last meeting. Has INT in 2 of his 3 career games vs. Car. & aims for his 4th in row vs. Car. with PD. • CB WILL JOHNSON became 1st rookie DB since 2020 (C.J. Henderson & Jaylon Johnson) with 3 PD in Week 1. • LB MACK WILSON had 8 tackles, TFL & PD in Week 1. • LB BARON BROWNING had 1st sack of season last week. Had sack in last meeting. • DL CALAIS CAMPBELL had 5 tackles last week. Has 5 sacks & 10 TFL in 10 career games vs. Car., incl. sack in his last game vs. Car. (12/17/23 w/ Atl.).
Game Odds
Carolina Panthers 45.5
Arizona Cardinals – 6.5
Odds Courtesy of Sports Odd Direct as of Saturday, September 13, 2025
