Game Details
Kickoff: 1:00 PM ET (10:00 AM PT)
Venue: Caesars Superdome, 1500 Sugar Bowl Drive, New Orleans, LA 70112
Surface: FieldTurf
Broadcast: CBS — Tom McCarthy (play‑by‑play), Ross Tucker & Logan Ryan (analysts)
Weather:
Injury Report
Arizona Cardinals
Will Hernandez (G) – Questionable (undisclosed)
Dalvin Tomlinson (DT) – Questionable (undisclosed)
No other major injuries reported; Kyler Murray fully healthy
New Orleans Saints
Chase Young (DE) – Questionable (calf)
Trevor Penning (OT) – Questionable
Brandin Cooks (WR) – Active; offseason signing expected to start
Devaughn Vele (WR) – Active; acquired via trade from Denver
Team Records & Recent Form
2024 Recap:
Cardinals: 8‑9, missed playoffs; offense improved late in season
Saints: 5‑12, last in NFC South; struggled offensively, QB instability
Recent Head‑to‑Head:
Last meeting: 2022 — Cardinals 42, Saints 34 (Glendale)
Series History: Cardinals lead regular‑season series 16‑15; Saints won only postseason meeting (2009 NFC Divisional, 45‑14)
Betting Trends
Cardinals 11‑6 ATS in 2024
Saints 7‑10 ATS in 2024
Over was 8‑8‑1 in Cardinals games; Under was 9‑8 in Saints games
Saints have won 6 straight season openers (longest active streak in NFL)
CARDINALS NOTES:
• QB KYLER MURRAY passed for 3,851 yards & 21 TDs & rushed for 572 yards & 5 TDs in career-high 17 starts in 2024. Can join Josh Allen as only players ever with 3,500+ pass yards & 500+ rush yards in 4 career seasons. Has 90+ rating in each of his past 3 Week 1 starts. Had 100.4 rating in last meeting. • RB JAMES CONNER had career-high 1,508 scrimmage yards (career-high 1,094 rush yards, 414 rec. yards) & 9 TDs (8 rush, 1 rec.) in 2024. Since joining Az. in 2021, ranks tied-5th among RBs with 37 rush TDs. Is 1 of 3 RBs (Derrick Henry & Joe Mixon) with 1,000+ scrimmage yards & 8+ scrimmage TDs in each of past 4 seasons. • TE TREY MCBRIDE set career highs in receptions (111) & rec. yards (1,146) in 2024, both 2nd-most among TEs last season. Can appear in 50th career game in Week 1. Has 5+ catches in 11 of his past 12 road games. • WR MARVIN HARRISON JR. ranked tied-2nd among rookies in rec. TDs (8) & 5th among rookies in receptions (62) & rec. yards (885) last season. • DL CALAIS CAMPBELL ranks 3rd among active players with 110.5 career sacks. Selected by Az. in 2nd round (No. 50 overall) in 2008 NFL Draft & had 56.5 sacks, 107 TFL & 42 PD in 138 games from 2008-16, 3rd-most sacks in franchise history. • LB JOSH SWEAT makes Ari. debut. Has 48 career sacks, incl. postseason. Had 2.5 sacks (with Phi.) in SB LIX at Caesars Superdome. • LB ZAVEN COLLINS led team with career-high 5 sacks in 2024. • CB GARRETT WILLIAMS set career highs with 58 tackles & 9 PD in 2024. • CB WILL JOHNSON was selected in 2nd round (No. 47 overall) in 2025 NFL Draft. • S BUDDA BAKER led team & ranked 2nd in NFL with career-high 164 tackles & had career-high 10 TFL in 2024, 1st DB since at least 2000 with 150+ tackles & 10+ TFL in single season. Is only DB with 85+ tackles in each of past 7 seasons. • S JALEN THOMPSON has 95+ tackles in 3 of his past 4 seasons.
SAINTS NOTES:
• QB SPENCER RATTLER passed for 1,317 yards & 4 TDs in 6 starts as a rookie in 2024. Has 20+ completions in each of his 1st 3 career home starts. • RB ALVIN KAMARA ranks 2nd among active RBs in scrimmage yards (11,541) & scrimmage TDs (85) entering 2025. Is only player with 1,100+ scrimmage yards in each of past 8 seasons. Has 573 career receptions & can become 5th RB all-time with 600+ career catches. Has 7 TDs (4 rush, 3 rec.) in 7 career Week 1 games. • WR CHRIS OLAVE has 70+ receptions & 1,000+ rec. yards in 2 of his 1st 3 career seasons. Had 7 catches for 106 yards in last meeting. • WR RASHID SHAHEED had 70+ rec. yards in 4 of his 6 games in 2024. Had 1st career rec. TD in last meeting. • WR BRANDIN COOKS was drafted by NO in 1st round (No. 20 overall) in 2014 NFL Draft & had 215 catches for 2,861 yards & 20 TDs in 42 games from 2014-16. • TE JUWAN JOHNSON set career highs in receptions (50) & rec. yards (548) in 2024. Had 2 rec. TDs in last meeting. • DE CAMERON JORDAN has franchise-record 121.5 career sacks, 2nd-most among active players. Has 5 sacks & 9 TFL in 5 career games vs Ari. • DE CARL GRANDERSON has 5+ sacks in 4 of past 5 seasons. • DT BRYAN BRESEE had career-high 7.5 sacks last season. • LB DEMARIO DAVIS led team with 136 tackles in 2024 & is 1 of 3 with 100+ tackles in each of past 8 seasons. Is 1 of 2 active players (Lavonte David) with 1,000+ tackles (1,377) & 100+ TFL (110). • CB ALONTAE TAYLOR set career highs in tackles (89), TFL (7), sacks (4) & PD (16) in 2024. Ranks tied-4th in NFL with 41 PD since 2022. • S JULIAN BLACKMON makes NO debut. Had 293 tackles, 21 PD, 13 TFL & 10 INTs in 5 seasons with Ind. • S JUSTIN REID makes NO debut. Has 565 tackles, 46 PD, 23 TFL & 10 INTs in 106 career games.
Game Odds
Arizona Cardinals – 6.5
New Orleans Saints 42.5
Odds Courtesy of Sports Odd Direct as of Saturday, September 6, 2025
