T-Mobile Park, Seattle, Washington
First pitch: 10:10 p.m. ET (7:10 p.m. PT)
TV: ESPN
The Astros sit tied atop the AL West and are fighting for a division title or wild-card berth. The Mariners are further back and playing out the schedule. This is the second game of a two-game series; Houston won the opener 7-0 on Tuesday behind strong pitching and power from Yordan Alvarez. The Mariners still lead the season series 9-3.
Probable Pitchers
Astros: RHP Ethan Pecko (1-0, 3.77 ERA, 1.12 WHIP, 19 K in 28.2 IP). The young right-hander has shown solid control in limited major-league action and makes another start after recent relief work.
Mariners: RHP George Kirby (9-11, 4.24 ERA, 1.39 WHIP, 143 K in 169.2 IP). The veteran has been inconsistent this season with a higher WHIP but remains a strikeout threat. He has mixed results against Houston previously.
Current Weather Forecast
Mostly cloudy to overcast and mild. High near 65–69°F, temperatures in the upper 50s to low 60s around first pitch, light winds (around 5–8 mph), low precipitation chance during game time. Typical cool Seattle evening conditions that can suppress offense.
Injury Reports
Astros:
SS Jeremy Peña (day-to-day)
CF Daulton Varsho (day-to-day, wrist)
SP Cristian Javier (day-to-day, groin — exited Tuesday’s game early)
SP Mike Burrows (60-day IL, elbow)
Longer-term absences including INF Carlos Correa and others.
Mariners:
RP Andrés Muñoz (day-to-day, leg)
INF Brendan Donovan (7-day IL, head)
Multiple 60-day IL players (Matt Brash, Luke Raley, Brennen Davis, Will Wilson, and others) plus several pitchers on shorter-term lists.
Key Rosters / Notable Players
Astros: DH Yordan Alvarez (.314 AVG, 41 HR, 102 RBI — Triple Crown contender), 3B Isaac Paredes, 1B Christian Walker (power), 2B Jose Altuve, SS Jeremy Peña (when healthy), C Yainer Diaz.
Mariners: LF Randy Arozarena (26 HR, strong OBP), CF Julio Rodríguez, 1B Josh Naylor, C Cal Raleigh, INF Cole Young, and supporting pieces.
Key Player vs. Player Matchups
Both right-handers face potent lineups. Kirby must contain Alvarez’s elite power and the Astros’ balanced attack. Pecko will be tested by Arozarena’s production and Rodríguez’s athleticism. T-Mobile Park’s dimensions and cooler weather typically favor pitchers.
Recent Team Forms
Astros: Mixed (3-7 in last 10 overall but snapped a skid with the shutout win Tuesday). Road record solid at 39-37. Motivated in a tight division race.
Mariners: Mixed (4-6 in last 10). Home record 40-36. Struggled offensively in the series opener.
Series History
13th meeting of 2026 (Mariners lead 9-3 overall; Astros lead the current series 1-0 after the 7-0 win). Seattle has dominated most of the season series.
Betting Trends
Kirby’s experience and home-field advantage give Seattle the edge on paper, but Houston’s superior offense and the series-opening shutout create underdog value. Cool conditions and the low total support the Under.
Game Odds
Houston Astros 7.5
Seattle Mariners – 135
Odds Courtesy of Sports Odds Direct as of Tuesday, September 22, 2026
