MLB Game Preview: Houston Astros (21-31) vs. Chicago Cubs (29-22)

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Chicago Cubs logo

Venue: Wrigley Field — Chicago, Illinois

First Pitch: 1:20 PM CT

Broadcast: Marquee Sports Network, AT&T SportsNet Southwest, MLB.TV

The Astros and Cubs wrap up their weekend set at Wrigley Field with a pitching matchup that heavily favors Chicago on paper. Houston continues to search for consistency amid a disappointing start, while the Cubs look to keep pace in the NL Central behind one of the league’s best rotations.

Venue & Weather

Wrigley Field — Chicago, IL

Weather Forecast (May 24):

  • Temperature: 72–75°F
  • Wind: 10–14 mph out to left field
  • Humidity: 55–60%
  • Rain: <10%
  • Impact:
    • Wind blowing out → boost for right-handed power hitters
    • Warm air increases carry
    • Could turn routine fly balls into extra-base hits

Injury Report

Houston Astros

  • Kyle Tucker — Day-to-day (wrist)
  • Yordan Álvarez — Active
  • José Altuve — Active
  • Justin Verlander — OUT (shoulder)
  • Cristian Javier — OUT (forearm)
  • Framber Valdez — Active

Chicago Cubs

  • Seiya Suzuki — Day-to-day (hamstring)
  • Cody Bellinger — Active
  • Dansby Swanson — Active
  • Jameson Taillon — OUT (elbow)
  • Julian Merryweather — OUT (lat)

Team Records & Recent Form

Houston Astros (21–31)

  • Last 10: 4–6
  • Trend: Offense inconsistent, pitching struggling
  • Strength: Middle-of-order power (Álvarez, Bregman)
  • Weakness: Rotation depth, bullpen fatigue

Chicago Cubs (29–22)

  • Last 10: 6–4
  • Trend: Pitching strong, offense improving
  • Strength: Starting rotation, plate discipline
  • Weakness: Occasional defensive miscues

Probable Pitching Matchup

Houston — RHP Peter Lambert (1–4, 5.12 ERA)

  • Profile:
    • Four-seam/slider mix
    • Pitch-to-contact righty
    • Vulnerable to hard contact vs left-handed hitters
  • Splits:
    • Vs RHB: .278 AVG
    • Vs LHB: .301 AVG
    • Road ERA: 5.40
  • Matchup Notes:
    • Cubs’ lefties (Bellinger, Busch) are dangerous
    • Wind blowing out is a concern for Lambert’s fly-ball tendencies

Chicago — LHP Shota Imanaga (6–1, 2.48 ERA)

  • Profile:
    • Elite command, deceptive fastball
    • High strikeout rate, low walk rate
    • One of MLB’s best offseason signings
  • Splits:
    • Vs RHB: .214 AVG
    • Vs LHB: .198 AVG
    • Home ERA: 2.31
  • Matchup Notes:
    • Astros’ right-handed bats (Altuve, Bregman, Peña) must be aggressive early
    • Imanaga’s fastball plays extremely well at Wrigley

Key Player Matchups

1. Yordan Álvarez (HOU) vs. Shota Imanaga

  • Álvarez is Houston’s best weapon vs lefties
  • Imanaga’s fastball up in the zone is a tough matchup Edge: Chicago

2. Cody Bellinger (CHC) vs. Peter Lambert

  • Bellinger thrives vs right-handed pitching
  • Lambert’s fly-ball profile + wind out = danger Edge: Chicago

3. José Altuve (HOU) vs. Imanaga

  • Altuve handles lefties well
  • But Imanaga’s command limits mistakes Edge: Even

4. Dansby Swanson (CHC) vs. Lambert

  • Swanson’s power to left field plays well in these conditions Edge: Chicago

Series History

  • 2025 Season: Cubs won 3–1
  • 2026 Season: Cubs lead season series 2–0 entering Sunday
  • At Wrigley Field (last 6): Cubs lead 4–2
  • Trend: Cubs’ pitching has consistently outperformed Houston in recent meetings

Betting Trends

Houston Astros

  • Astros are 3–7 in last 10 road games
  • Over is 5–2 in last 7 Astros games
  • Houston is 1–6 in Lambert’s last 7 starts

Chicago Cubs

  • Cubs are 6–1 in Imanaga’s last 7 starts
  • Under is 4–1 in Cubs’ last 5 home games
  • Cubs are 8–3 in last 11 overall

GAME ODDS

Houston Astros                 7.5

Chicago Cubs                     – 169

Odds Courtesy of Sports Odds Direct as of Saturday, May 23, 2026