First Pitch: 7:40 PM ET
Venue: Wrigley Field, 1060 W Addison St, Chicago, IL
Weather Outlook (Chicago – April 22, 2026)
No direct weather data surfaced in search results. Inference: Early‑evening April games at Wrigley typically feature upper‑40s to mid‑50s temperatures, light winds, and moderate humidity. Wind direction can meaningfully affect totals at this ballpark.
Injury Report
Philadelphia Phillies
No new injuries listed in available sources for April 22.
Bryce Harper remains active and hot at the plate (HR on Apr 21).
Chicago Cubs
No injuries reported in the available sources for April 22.
Team Records & Recent Form
Philadelphia Phillies (8–15)
Road Record: 3–5
Streak: L7 — outscored 49–14 during the slide.
Offense: .220 AVG, 3.5 runs/game (27th in MLB).
Pitching: 4.87 ERA (28th), 1.42 WHIP.
Chicago Cubs (14–9)
Home Record: 9–5
Streak: W7 — outscored opponents 51–18 during the run.
Offense: Power surge from Hoerner & Suzuki (HRs on Apr 21).
Pitching: Shota Imanaga dominating (2.17 ERA after Apr 21).
Probable Pitching Matchup
Philadelphia – Tyler Backhus (LHP)
0–0, 5.40 ERA, 9 K
Limited MLB sample; matchup data shows Cubs hitters have minimal exposure.
Chicago – Matthew Boyd (LHP)
1–1, 6.75 ERA, 17 K
Returning from IL for his third start.
Phillies hitters with success vs Boyd:
Alec Bohm: .667 AVG (2-for-3)
Bryce Harper: .333 AVG (1-for-3)
Key Player Matchups
Phillies
Bryce Harper: .328 in April, 5 HR; homered Apr 21.
Kyle Schwarber: 8 HR on season; hit solo HR Apr 21.
Cubs
Nico Hoerner: HR on Apr 21; hitting well vs LHP.
Seiya Suzuki: 2‑run HR Apr 21; OPS spike during win streak.
Michael Busch: 2‑RBI single broke tie in Apr 21 win.
Series History
Cubs lead current series 2–0 entering Apr 22.
Apr 21: Cubs won 7–4, extending Phillies’ losing streak to seven.
Cubs have won seven straight overall and are one of MLB’s hottest teams.
Betting Trends
Philadelphia
0–7 in last seven games.
Offense averaging 2.0 runs/game during losing streak. (inferred from 14 runs in 7 games)
Bullpen: 83.3% save rate but limited opportunities.
Chicago
7–0 in last seven.
Averaging 7.3 runs/game during streak. (51 runs in 7 games)
Strong home performance and consistent mid‑game scoring bursts.
Game Odds
Philadelphia Phillies 8
Chicago Cubs – 171
Odds Courtesy of Sports Odds Direct as of Tuesday, April 21, 2026
