Game Details
Kickoff: 1:00 PM ET (10:00 AM PT)
Venue: Lucas Oil Stadium, 500 S Capitol Ave, Indianapolis, IN 46225
Surface: FieldTurf
Broadcast: CBS (Andrew Catalon, Charles Davis, Jason McCourty, AJ Ross) (regional coverage: all of Florida, most of Indiana, TN, parts of IL, MI, KY, VA, GA, NC, AL)
Weather:
Final Injury Report
Miami Dolphins
Out: CB Ethan Bonner (hamstring), TE Darren Waller (hip), RB Jaylen Wright (knee)
Questionable: OL James Daniels (ankle), WR Dee Eskridge (concussion)
Indianapolis Colts
Questionable: RB Tyler Goodson (elbow)
Key Player Matchups
Tua Tagovailoa & Tyreek Hill (MIA) vs. Colts Secondary
Hill’s speed and chemistry with Tua will test a Colts backfield featuring ex-Dolphin Xavien Howard.
Jonathan Taylor (IND) vs. Dolphins Front Seven
Taylor’s power running (1,431 yards in 2024) meets a revamped Miami defensive interior anchored by Zach Sieler and rookie Kenneth Grant.
Colts O-Line vs. Dolphins Pass Rush
Daniel Jones’ protection will be critical against Miami’s edge threats and blitz packages.
Recent Form & Trends
Miami: Won 4 of last 5 season openers; 5–2 ATS in last 7 Week 1 games.
Indianapolis: Lost 10 straight Week 1 games (last win in 2013).
Head-to-Head: Colts have won 4 of last 5 meetings, including 16–10 in Week 7 of 2024.
Series History
All-Time Regular Season: Dolphins lead 46–29
Largest Dolphins Win: 44–0 (1973)
Largest Colts Win: 41–0 (1997)
Betting Trends
Over has hit in 4 of Colts’ last 6 home games.
Dolphins 3–1 ATS in last 4 road games vs. AFC opponents.
Colts 2–5 ATS in last 7 as home underdogs.
DOLPHINS NOTES:
• QB TUA TAGOVAILOA led NFL with 72.9 comp. pct. last season & totaled 2,867 pass yards & 19 TD passes with 101.4 rating in 11 starts. Is only QB in NFL with 100+ rating in each of past 3 seasons (min. 100 atts. each season). Is 4-0 with 100.6 rating in 4 career starts in Week 1. • RB DE’VON ACHANE led team with career-high 1,499 scrimmage yards (907 rush, 592 rec.) & 12 TDs (6 rush, 6 rec.) & was only player in NFL with 500+ rush yards, 500+ rec. yards, 5+ rush TDs & 5+ rec. TDs. Rushed for 77 yards in last meeting. • WR TYREEK HILL totaled 81 catches for 959 yards & 6 TDs last season & became 3rd player in NFL history with 6+ rec. TDs in each of 1st 9 seasons. Since joining Mia. in 2022, leads NFL with 4,468 rec. yards. • WR JAYLEN WADDLE had 58 catches for 744 yards in 15 games last season. Is 1 of 3 in franchise history with 50+ catches in each of 1st 4 seasons. • WR NICK WESTBROOK-IKHINE can make Mia. debut after totaling career-high 9 rec. TDs last season with Ten. Aims for his 3rd in row vs. Ind. with TD catch. • TE DARREN WALLER can make Mia. debut after sitting out 2024 season. • DT ZACH SIELER led team with career-high 13 TFL & 10 sacks last season, 2nd-straight 10-sack season. Finished season with sack in 4 of his final 5 games. Had FR in last meeting. • LB CHOP ROBINSON ranked 2nd among rookies with 6 sacks in 2024. • LB MATTHEW JUDON can make Mia. debut after totaled 5.5 sacks & 7 TFL last season with Atl. Has 5+ sacks in 7 of his past 8 seasons. Had 3 sacks in his last game vs. Ind. (11/6/22 w/ NE). • LB JORDYN BROOKS led team with 143 tackles in 2024, 4th-straight season with 100+ tackles. Had 7 tackles, TFL & PD in last meeting. • LB JAELAN PHILLIPS has 7.5 sacks over 12 games past 2 seasons. • S MINKAH FITZPATRICK returns to Mia. after spending past 5+ seasons with Pit.
COLTS NOTES:
• QB DANIEL JONES can make Ind. debut after totaling 14,582 pass yards & 85 TDs (70 pass, 15 rush) over past 6 seasons with NYG (2019-24). • RB JONATHAN TAYLOR ranked 6th among RBs with 1,567 scrimmage yards (1,431 rush, 136 rec.) & had 12 TDs (11 rush, 1 rec.) in 2024, 3rd-career season with 1,100+ rush yards & 11+ rush TDs. Finished season with 100+ scrimmage yards in each of his final 5 games & rush TD in each of final 3. Had 790 rush yards (112.9 per game) & 8 rush TDs in 7 home games last season. Since entering NFL in 2020, ranks 2nd among RBs with 6,013 rush yards & 3rd with 51 rush TDs. Rushed for 103 yards & TD in his last game vs. Mia. (10/3/21). • WR MICHAEL PITTMAN had 69 catches for 808 yards in 2024 & is 1 of 4 in franchise history with 500+ rec. yards in each of 1st 5 seasons. Aims for his 3rd in row vs. Mia. with 55+ rec. yards. • WR JOSH DOWNS set career highs in catches (team-high 72), rec. yards (803) & rec. TDs (5) last season. • WR ALEC PIERCE led team with career-high 824 rec. yards & 7 rec. TDs in 2024. Had TD catch in 3 of his final 4 games of season. • TE TYLER WARREN was selected No. 14 overall in 2025 NFL Draft, highest selected TE in franchise history. • DE KWITY PAYE led team with 8 sacks & had 10 TFL last season. • DT DEFOREST BUCKNER had 6.5 sacks in 2024 & is only DT in NFL with 6+ sacks in each of past 7 seasons. • LB ZAIRE FRANKLIN led NFL with 173 tackles & ranks tied-2nd with career-high 5 FFs last season. Had 16 tackles & FF in last meeting. • CB XAVIEN HOWARD can make Ind. debut after totaling 95 PD & 29 INTs over 100 games with Mia. (2016-23). • CB CHARVARIUS WARD can make Ind. debut after totaling 41 PD & 6 INTs over past 3 seasons with SF (2022-24). Has PD in 2 of 3 career games vs. Mia.
Game Odds
Miami Dolphins 47
Indianapolis Colts – 1.5
Odds Courtesy of Sports Odd Direct as of Saturday, September 6, 2025
