The San Francisco 49ers welcome the struggling Tennessee Titans to Levi’s Stadium in a Week 15 lopsided affair on Sunday, December 14, 2025, as the Niners chase a playoff bye with a potential six-game win streak, while the Titans limp in on a nine-game skid, eyeing draft positioning. This marks the Titans’ first visit to Santa Clara since 2017, reviving a series where San Francisco holds the edge, but Tennessee’s recent road upset over Denver (22-21) adds faint spoiler hope. Brock Purdy’s efficient arm (242.6 pass ypg, 6th) and Christian McCaffrey’s dual-threat (849 rush yds/8 TD) face a Titans D ranked 29th in points allowed (27.5 OPP PPG), but Will Levis’ turnover-prone play (12 TD/16 INT) meets the NFL’s 8th-ranked 49ers secondary (198 pass ypg allowed). With the 49ers holding the NFC’s No. 3 seed and Titans dead last in the AFC South, expect a Niners rout to cap their pre-Christmas surge. Win sims: 49ers 82%.
Kickoff: 4:25 PM ET (1:25 PM PT).
Broadcast: FOX: Adam Amin, Drew Brees, Kristina Pink (field reporter)
Streaming on NFL+ ($6.99/mo) and YouTube TV. Pregame analysis starts at 3:30 PM ET on FOX Sports 1.
Venue Location:
Levi’s Stadium, 4900 Marie P. DeBartolo Way, Santa Clara, CA 95054 (37°24’18″N 121°58’02″W). This 68,500-seat open-air marvel—opened in 2014—features a translucent roof and stunning Bay Area views, hosting Super Bowl 50 and delivering a charged atmosphere with premium suites. Accessible via US-101 (Great America Parkway exit) or San Jose International Airport (SJC, 10-min drive).
Weather Updates
Levi’s Stadium’s open-air design exposes players to mild Bay Area December conditions, favoring a passing showcase without extreme elements. Game-time forecast: 64°F with mostly sunny skies (1% precipitation chance) and light southwest winds at 2 mph (gusts to 4 mph), yielding feels-like temps near 64°F. Humidity 55%, UV index 2 (low). Impacts: Ideal for aerial attacks (+5% completion in calm, sunny weather per NFL data); 49ers 5-1 home in 60-70°F games, Titans 1-4 road mild. No delays expected—perfect for fan tailgates.
Injury Report
Both teams report clean bills post-Thursday, but the 49ers’ star RB and Titans’ secondary depth draw concern—San Francisco emerges healthier overall. Updates as of December 11 (via NFL.com; Friday reports pending).
Tennessee Titans:
DNP: LB James Williams (illness—second straight DNP, questionable).
Limited: CB Jalyn Armour-Davis (Achilles—limited), C Lloyd Cushenberry (foot—limited), OT Dan Moore (neck—limited after full Wed).
Full: TE Chig Okonkwo (rest—full), RB Tony Pollard (rest—full), DT Shy Tuttle (concussion—full).
Impact: Williams’ illness thins LB coverage vs. McCaffrey; Moore’s neck limits OL protection for Levis (team 28th, 24 sacks allowed). Secondary holds with Armour-Davis trending up.
San Francisco 49ers:
DNP: LB Tatum Bethune (ankle—DNP), FB Kyle Juszczyk (ribs—limited Wed, DNP Thu), DE Sam Okuayinonu (ankle—DNP).
Limited: RB Christian McCaffrey (illness—limited, no designation; expected to play, 849 rush yds/8 TD).
Full: OT Trent Williams (rest—full after Wed DNP).
Impact: McCaffrey’s illness (no long-term worry) caps early snaps, leaning on Jordan Mason; Juszczyk’s ribs hurt blocking. Front seven intact with Okuayinonu out.
Full practices Thursday; no QB issues (Levis/Purdy cleared).
Player Matchups
This mismatch highlights San Francisco’s firepower vs. Tennessee’s grit, with Purdy’s precision vs. Titans’ blitzes a pivotal edge. Key stylistic clashes:
QB Will Levis (TEN) vs. 49ers Pass Rush (Nick Bosa/L Leonard Floyd): Levis (12 TD/16 INT, 58.2% comp.) flopped in 2024 vs. SF (198 yds/2 INT)—Bosa (12 sacks) exploits TEN’s 28th OL (24 sacks allowed).
RB Tony Pollard (TEN) vs. 49ers Front 7 (Fred Warner/Arik Armstead): Pollard (92 yds last) tests SF’s 12th run D (107.7 ypg allowed). TEN’s 31st rush (84.9 ypg) vs. Warner’s tackling.
WR Calvin Ridley (TEN) vs. CB Charvarius Ward/Deommodore Lenoir: Ridley (57 yds last) vs. Ward’s coverage (9 PD); Lenoir’s slot on underneath routes.
QB Brock Purdy (SF) vs. Titans Secondary (Roger McCreary/Quandre Ellison): Purdy (242.6 ypg, 6th) vs. TEN’s 29th pass D (27.5 OPP PPG). Titans blitz light (22 sacks).
RB Christian McCaffrey (SF) vs. Titans Front (Jeffery Simmons/Harold Landry): McCaffrey (65.3 ypg, 8 TD) vs. TEN’s 10th run D (107.1 ypg allowed); Landry’s edge vs. SF’s 15th OL.
49ers Offense Edge: Deebo Samuel/Purdy connection vs. Titans’ man coverage.
Team Records
| Team | Record | Division | Playoff Odds | Key Stats |
| Titans | 2-11 (.154) | 4th AFC South | 0% | 15.5 PPG (31st), 27.5 OPP PPG (29th), 246.2 TOT YPG (32nd) |
| 49ers | 9-4 (.692) | 1st NFC West | 98% | 23.6 PPG (16th), 20.7 OPP PPG (8th), 355.7 TOT YPG (6th) |
Titans: Nine-game skid, last in South. 49ers: Three-game win streak, West lead.
Recent Form
Tennessee Titans (1-4 in last 5): Dismal stretch with Levis’ INTs (5 last 4 games); offense sputters (12.2 PPG last 5), D middling (27.5 OPP PPG).
| Date | Opponent | Result | Key Notes |
| Dec 7 | @ DEN | W 22-21 | Levis 265 yds/2 TD; Pollard 67 yds, upset road win. |
| Nov 30 | vs LAR | L 19-33 | Levis 143 yds/1 TD; 57.6% 3rd-down. |
| Nov 23 | vs IND | L 20-41 | Levis 196 yds/1 TD; Ridley 57 yds. |
| Nov 16 | @ HOU | L 0-26 | Levis 93 yds/0 TD; shutout. |
| Nov 9 | vs JAX | L 10-20 | Levis 222 yds/1 TD; Pollard 34 yds. |
San Francisco 49ers (4-1 in last 5): Resurgent with Purdy’s command (90.8 rating); balanced (355.7 ypg), D forces TOs (1.4/g).
| Date | Opponent | Result | Key Notes |
| Nov 30 | @ CLE | W 26-8 | Purdy 252 yds/3 TD; McCaffrey 61 yds. |
| Nov 24 | vs CAR | W 20-9 | Purdy 340 yds/2 TD; 53.8% 3rd-down. |
| Nov 16 | @ ARI | W 41-22 | Purdy 281 yds/5 TD; Williams 73 yds. |
| Nov 9 | vs LAR | L 26-42 | Purdy 393 yds/4 TD; shootout loss. |
| Nov 2 | @ NYG | W 34-24 | Purdy 380 yds/4 TD; 54.5% 3rd-down. |
Series History
The 49ers lead all-time 9-6 (15 meetings, no playoffs), with San Francisco winning 3 of last 4 (avg. score: SF 22.5-19.8 TEN). Last: SF 25-23 (2017). Trend: Close (8/15 <7 pts); O/U: O 7-8. December: 49ers 3-1 SU home vs. TEN. ATS: Titans 6-9.
Betting Trends
Under edges 62% action at 44.5 (U 7/10 49ers, series U 7-8). Titans +12.5 lags with 8% handle, viewed as fade (1-4 ATS last 5 road); 49ers 8-5 ATS overall (5-2 home). TEN 0-5 SU last 5; X buzz 85% pro-SF post-bye. Stable lines; no drift expected.
Predicted Score: San Francisco 49ers 34, Tennessee Titans 20
TITANS NOTES:
• QB CAM WARD passed for 117 yards & 2 TDs in Week 14. Leads rookies in passing yards (2,468) & ranks 2nd in TD passes (9). Has TD pass in 3 of his past 4. Aims for his 4th in row on road with TD pass. • RB TONY POLLARD led team with career-high 161 rush yards & had 2 rush TDs last week. Aims for his 3rd in row with 60+ rush yards. • RB TYJAE SPEARS had 47 scrimmage yards (28 rec., 19 rush) in Week 14. Has 45+ scrimmage yards in 5 of his past 6 on road. • WR CHIMERE DIKE (rookie) had TD catch last week. Has TD catch in 2 of his past 3. Aims for his 3rd in row on road with 5+ receptions. • WR ELIC AYOMANOR (rookie) had TD catch in Week 14. • TE CHIG OKONKWO has 45+ rec. yards in 3 of his past 4 on road. • DT JEFFERY SIMMONS had 7 tackles, 2 TFL, 1.5 sacks & PD last week. Has sack in 3 of his past 4. Aims for his 6th in row on road with sack & 3rd in row overall with 6+ tackles. • LB CODY BARTON had 5 tackles & 3 PD in Week 14. Aims for his 4th in row on road with PD & 4th in row vs. SF with 10+ tackles. Had 12 tackles & TFL in his last game vs. SF (12/31/23 w/ Was.). • LB CEDRIC GRAY led team with 10 tackles & had FR last week. Aims for his 6th in row with 7+ tackles. • LB ARDEN KEY had 3 tackles in Week 14. Had 22 tackles, 6.5 sacks, 5 TFL & PD in 2021 with SF. • S AMANI HOOKER had 6 tackles last week. Had 6 tackles & INT in last meeting. • S XAVIER WOODS had 3 tackles & INT in Week 14. Had 6 tackles & PD in his last game vs. SF (11/28/21 w/ Min.). • S KEVIN WINSTON (rookie) had 5 tackles, 2 TFL & 2 PD last week. Aims for his 5th in row with 5+ tackles. • CB MARCUS HARRIS (rookie) had 4 tackles & 1st-career FF in Week 14.
CHIEFS NOTES:
• QB BROCK PURDY passed for 168 yards & TD & had 1st rush TD of season in Week 13. Has TD pass & 150+ pass yards in all 5 games played this season. • RB CHRISTIAN MCCAFFREY had 74 scrimmage yards (53 rush, 21 rec.) & rush TD in Week 13. Has 849 rush yards & 806 rec. yards in 2025 & is 1 of 2 (HOFer Marshall Faulk) in NFL history with 800+ rushing yards & 800+ rec. yards in 3 career seasons. Is 3rd player in NFL history (HOFer LaDainian Tomlinson – 6 seasons & Shaun Alexander – 5) with 1,600+ (1,655) & 13+ TDs (13) in five career seasons. Ranks 3rd in NFL with 1,655 scrimmage yards & 5th with 85 receptions in 2025. Aims for 4th in row with rush TD. Had 146 rush yards & 3 TDs (2 rush, 1 rec.) in last game vs. Ten. (11/3/19 w/ Car.). • WR JAUAN JENNINGS had TD catch in Week 13 & has rec. TD in 4 of his past 5. • TE GEORGE KITTLE led team with 67 rec. yards in Week 13 & aims for 5th in row with 65+ rec. yards. Ranks tied-6th among TEs with 5 TD catches in 2025. Has 7,776 rec. yards & 50 rec. TDs since 2017 & is 5th TE in NFL history with 7,500+ rec. yards & 50+ rec. TDs in 1st 9 seasons. • LB DEE WINTERS had 6 tackles in Week 13 & has 5+ tackles in 5 of his past 6. Has TFL in 3 of his past 4 at home. • LB TATUM BETHUNE has 10+ tackles in 5 of his past 6 games. • DE CLELIN FERRELL led team with 9 tackles & 2 sacks in Week 13. Aims for 3rd in row with sack. • DE KEION WHITE had 1st full sack of season in Week 13. • CB UPTON STOUT (rookie) had 7 tackles & TFL in Week 13 & aims for 4th in row with 6+ tackles. • S JI’AYIR BROWN aims for 3rd in row at home with PD. Has 5+ tackles in 3 of his past 4 games. • S MALIK MUSTAPHA had 7 tackles, TFL & PD in Week 13. Has 7+ tackles in 3 of his past 4. Aims for 3rd in row with TFL.
Game Odds
Tennessee Titans 44.5
San Francisco 49ers – 12.5
Odds Courtesy of Sports Odd Direct as of Saturday, December 13, 2025
