Venue & Event Details
Kickoff: Sunday, October 5, 2025 – Kickoff 4:05 p.m. ET (3:05 p.m. CT / 1:05 p.m. PT)
Venue: State Farm Stadium, One Cardinals Drive, Glendale, Arizona 85305
Broadcast: CBS: Spero Dedes, Adam Archuleta, Aditi Kinkhabwala (field reporter)
Weather Update (Glendale, AZ)
Forecast: Sunny, dry desert conditions
Temperature at Kickoff: ~88°F (31°C) outside
Impact: Game will be played indoors under the retractable roof at State Farm Stadium, so weather will not affect play.
Injury / Suspension Report
Tennessee Titans [^2]^4][^9]
OUT: RT JC Latham (hip)
OUT: WR Calvin Ridley (knee/elbow)
OUT: RG Kevin Zeitler (foot)
IR: RB Tyjae Spears (ankle, still rehabbing)
QB: Rookie Cam Ward (4 starts, 0‑4 record, 2 TDs, 5 INTs, 17 sacks taken)
Arizona Cardinals ^6][^9]
OUT: RB James Conner (season-ending foot injury)
OUT: RB Trey Benson (knee, IR)
QUESTIONABLE: CB Will Johnson (groin)
QUESTIONABLE: DL Darius Robinson (chest)
QB: Kyler Murray (742 passing yards, 6 TDs, 3 INTs; 148 rushing yards through 4 games)
Key Player Matchups
Cam Ward (TEN) vs. Cardinals Pass Rush: Ward has been sacked 17 times (most in NFL). Arizona’s Calais Campbell (3 sacks) and Mack Wilson (35 tackles) will look to exploit Tennessee’s battered O‑line.
Tony Pollard (TEN) vs. Cardinals Run Defense: Pollard has struggled behind a weak line, but Arizona allows 4.0 YPC despite ranking top‑10 in rush defense.
Marvin Harrison Jr. (ARI) vs. Titans Secondary: Harrison has 16 catches, 208 yards, 2 TDs. Tennessee’s secondary ranks 22nd vs. the pass.
Jeffery Simmons (TEN) vs. Cardinals O‑Line: With Arizona missing multiple linemen, Simmons has a chance to disrupt Murray’s rhythm.
Trey McBride (ARI) vs. Titans Linebackers: McBride has 24 catches for 234 yards, 1 TD — a mismatch against Tennessee’s coverage unit.
Team Records & Recent Form
Tennessee Titans
Record: 0‑4 (last in AFC South)
Last 5: L‑L‑L‑L
Last Game: 26‑0 loss at Houston (Week 4, first shutout since 2019)
Offense: 31st overall, 32nd in scoring (12.8 PPG), 32nd in passing, 29th in rushing
Defense: 25th overall, 28th vs. run, 22nd vs. pass, 28th in scoring (27.5 PPG allowed)
Arizona Cardinals
Record: 2‑2 (3rd in NFC West)
Last 5: W‑W‑L‑L
Last Game: 23‑20 loss vs. Seattle (Week 4, late collapse)
Offense: 28th overall, 23rd in scoring (20.5 PPG), 28th in passing, 22nd in rushing
Defense: 23rd overall, 9th vs. run, 28th vs. pass, 6th in scoring (18.5 PPG allowed)
Series History
All-time: Cardinals lead 8‑4 [^9]
Last Meeting: Sept. 12, 2021 – Cardinals 38, Titans 13 (in Nashville; Kyler Murray 5 total TDs)
At Glendale: Only the second Titans visit to State Farm Stadium.
Betting Trends
Titans are 1‑3 ATS this season.
Cardinals are 2‑2 ATS.
Titans have lost 10 straight games dating back to 2024.
Titans have been outscored 47‑10 in 4th quarters this season.
Cardinals have lost 2 straight by a combined 4 points.
Arizona is 2‑0 this season when favored.
TITANS NOTES
• QB CAM WARD (rookie) passed for 108 yards in Week 4. Has TD pass in 2 of his past 3. • RB TONY POLLARD led team with 76 scrimmage yards (64 rush, 12 rec.) last week. Aims for his 6th in row with 50+ scrimmage yards. Rushed for 122 yards in his last game vs. Ari. (9/24/23 w/ Dal.). • WR CALVIN RIDLEY had TD catch in his last game vs. Ari. (10/13/19 w/ Atl.). • WR TYLER LOCKETT has 71 catches for 1,010 yards & 9 TDs in 12 career games vs. Ari. • WR ELIC AYOMANOR (rookie) led team with 44 rec. yards in Week 4. Has TD catch in 2 of his past 3. • WR VAN JEFFERSON has TD catch in 3 of his past 4 vs. Ari. • TE CHIG OKONKWO has 4+ catches in 2 of his past 3. • DT JEFFERY SIMMONS had 5 tackles, 4 TFL & sack last week. Has sack in 3 of his past 4 on road. Had 5 tackles & sack in last meeting. • LB CODY BARTON had 9 tackles in Week 4. Aims for his 10th in row with 5+ tackles on road. Had 5 tackles in his last game vs. Ari. (9/10/23 w/ Was.). • LB CEDRIC GRAY led team with career-high 17 tackles & had 1st-career TFL last week. Has 7+ tackles in 3 of his past 4 on road. • LB ARDEN KEY had 1st sack of season in Week 4. Has sack in his last game vs. Ari. (11/7/21 w/ SF). • S AMANI HOOKER had 5 tackles last week & aims for his 9th in row with 5+ tackles. Had 6 tackles in last meeting. • S QUANDRE DIGGS had 5 tackles & 1st PD of season in Week 4. Has 5+ tackles in 3 of his past 4 on road. Had 6 tackles & TFL in his last game vs. Ari. (1/7/24 w/ Sea.). • S XAVIER WOODS had 4 tackles last week. Had 6 tackles in his last game vs. Ari. (12/22/24 w/ Car.). • CB L’JARIUS SNEED had 8 tackles, sack & PD in his last game vs. Ari. (9/11/22 w/ KC).
CARDINALS NOTES
• QB KYLER MURRAY totaled 241 yards (200 pass, season-high 41 rush) & 2 pass TDs last week. Aims for his 8th in row with TD pass. Passed for 289 yards & had career-high 5 TDs (4 pass, 1 rush) vs. INT for 121 rating in last meeting, 1 of 3 career games with 4 TD passes. • RB EMARI DEMERCADO had 1st-career rec. TD last week. • RB TREY BENSON had career-high 5 catches & 54 scrimmage yards (35 rush, 19 rec.) in Week 4. Has 50+ scrimmage yards in 3 of 4 games this season. • TE TREY MCBRIDE had season-high 7 catches for 52 yards & aims for his 7th in row with 5+ catches. Aims for his 7th in row at home with 50+ rec. yards. Since 2023, leads all TEs in receptions (216) & & rec. yards (2,205). • WR MARVIN HARRISON JR. had 6 catches for 66 yards & 2nd rec. TD of season last week, his 10th-career TD catch. Has 5+ catches, 60+ rec. yards & rec. TD in 2 of his past 3 at home. • DL CALAIS CAMPBELL had sack & 2 TFL last week & aims for his 3rd in row at home with sack & 2 TFL. Has 13 TFL & 5.5 sacks in 10 career games vs. Ten. • DL DARIUS ROBINSON had career-high 2 TFL & 2nd-career sack last week. • LB JOSH SWEAT had 46th-career sack & 9th-career FF last week. Aims for his 3rd in row at home & 4th in row overall with sack. Had 2 sacks in his only career game vs. Ten. (12/4/22 w/ Phi.). • LB MACK WILSON has 5 PD in his past 5. Aims for his 5th in row with 7+ tackles. • LB AKEEM DAVIS-GAITHER had season-high 8 tackles & TFL last week. Had 12 tackles in his last game vs. Ten. (12/15/24 w/ Cin.). • CB MAX MELTON had 1st-career game with 2 PD last week. • S BUDDA BAKER has 5+ tackles in 22 straight games, longest active streak among DBs. Aims for his 3rd in row vs. Ten. with 7+ tackles & PD. • S JALEN THOMPSON led team with 9 tackles last week. Aims for his 6th in row at home & 10th in row overall with 6+ tackles.
Game Odds
Tennessee Titans 41.5
Arizona Cardinals – 7.5
Odds Courtesy of Sports Odd Direct as of Saturday, October 4, 2025
