Venue & Game Details
Kickoff Time: 8:15 PM EDT / 5:15 PM PDT
Venue: State Farm Stadium, Glendale, Arizona
Capacity: ~63,400 (expandable to 72,000)
Conference: NFC West divisional matchup
Broadcast: Prime Video: Al Michaels, Kirk Herbstreit, Kaylee Hartung (field reporter)
Westwood One: Kevin Kugler, Ryan Harris
Injury Report
Seattle Seahawks:
CB Devon Witherspoon (hamstring) – limited in practice, questionable.
S Julian Love (shoulder) – limited, questionable.
S Nick Emmanwori (ankle) – limited, questionable.
RB Zach Charbonnet (hamstring) – expected to return.
FB Robbie Ouzts (ankle) – out.
T Josh Jones (ankle) – out.
Arizona Cardinals:
RB James Conner (foot) – out for season, major loss.
RB Trey Benson – expected to start, has shown explosive runs.
OL Kelvin Beachum (knee) – DNP, questionable.
CB Will Johnson (groin) – DNP, questionable.
WR Zay Jones (concussion) – DNP, questionable.
OT Paris Johnson Jr. (knee) – limited, status uncertain.
Key Player Matchups
Sam Darnold (SEA QB) vs. Cardinals Secondary
Darnold has completed 70.3% of passes with 4 TDs and 2 INTs.
Arizona’s pass defense ranks 30th in the NFL, a clear mismatch.
Trey Benson (ARI RB) vs. Seahawks Run Defense
Benson replaces Conner and has already broken off runs of 29 and 52 yards this season.
Seattle’s run defense ranks 7th in the NFL, allowing just 90 ypg.
Tory Horton (SEA WR) vs. Cardinals Coverage
Rookie WR Horton had a 95-yard punt return TD and 2 receiving TDs already.
Arizona’s secondary has struggled against explosive plays.
Recent Team Form
Seattle Seahawks (2–1)
W 44–13 vs. Saints (Week 3)
L 20–23 @ Lions (Week 2)
W 24–17 vs. Rams (Week 1)
Strengths: Balanced offense, opportunistic defense (2nd in scoring defense).
Weaknesses: Run game inconsistent (21st in rushing).
Arizona Cardinals (2–1)
L 15–16 vs. 49ers (Week 3)
W 27–20 @ Commanders (Week 2)
W 24–17 vs. Broncos (Week 1)
Strengths: Run defense (4th in NFL).
Weaknesses: Passing offense (28th in NFL).
Conference vs. Conference
Both teams are NFC West rivals.
Seattle is looking to extend its 7-game winning streak vs. Arizona (dating back to 2021).
Both teams are 2–1, making this a pivotal early-season divisional clash.
Series History
All-time series: Seahawks lead 29–22–1.
Last meeting: Seattle won 30–18 on Dec. 8, 2024, in Glendale.
Trend: Seattle has won the last 7 straight matchups.
Betting Trends
Seattle Seahawks:
2–1 ATS in 2025.
5–0 straight up vs. Arizona in last 5 meetings.
2 of 3 games have gone Over this season.
Arizona Cardinals:
2–1 ATS in 2025.
1–4 ATS in last 5 vs. Seattle.
2 of 3 games have gone Under this season.
Historical Betting Results
2024: Seattle -3.5 covered in 30–18 win (Under cashed).
2023: Seattle -6.5 covered in 27–14 win (Under cashed).
2022: Seattle -2.5 covered in 31–21 win (Over cashed).
SEAHAWKS NOTES
• QB SAM DARNOLD passed for 218 yards & 2 TDs vs. 0 INTs for 154.2 rating in Week 2, 2nd-highest single-game passer rating in career. Has 13 games with 2+ TD passes & 100+ rating since 2024, most in NFL. Aims for his 3rd in row with 2+ TD passes. Passed for 235 yards & 2 TDs vs. 0 INTs for 111.6 rating in his last start vs. Ari. (12/1/24 w/ Min.). • RB KENNETH WALKER rushed for 2 TDs last week, his 8th-career game with 2+ scrimmage TDs. Aims for his 3rd in row with rush TD. Has 7 TDs (6 rush, 1 rec.) in his past 5 on road. Aims for his 6th in row vs. Ari. with 80+ scrimmage yards. • WR JAXON SMITH-NJIGBA led team with 5 catches for 96 yards & had 1st rec. TD of season last week, his 11th-career TD catch. Is only player with 95+ rec. yards in each of 1st 3 weeks. Has TD catch in 3 of his 4 career games vs. Ari. & aims for his 3rd in row vs. Ari. with rec. TD. • WR COOPER KUPP has 5+ catches in 7 of his past 8 Thursday games. • WR TORY HORTON had TD catch & 95-yard PR-TD in Week 3, longest PR-TD in Sea. history & longest PR-TD by rookie since 2016 (Tyreek Hill). Aims for his 3rd in row with rec. TD. • LB ERNEST JONES aims for his 8th in row vs. Ari. & 19th in row overall with 5+ tackles. Had INT in last meeting. Has PD in 3 of his 4 career games at Ari. • DE LEONARD WILLIAMS aims for his 3rd in row with 0.5+ sacks. Aims for his 3rd in row vs. Ari. with PD & 4th in row vs. Ari. with TFL. Aims for his 5th in row on Thursday with TFL. • DT BYRON MURPHY aims for his 3rd in row with sack. • CB JOSH JOBE had career-high 11 tackles last week. Aims for his 3rd in row vs. Ari. & 4th in row overall with PD. • CB DERION KENDRICK tied his career-high with 3 PD & had 3rd-career INT last week. Aims for his 3rd in row with 2+ PD & INT. • S COBY BRYANT had career-high 2 PD last week.
CARDINALS NOTES
• QB KYLER MURRAY Aims for his 7th in row with TD pass. Had 200+ pass yards, TD pass & 100+ rating in 3 of his 4 career Thursday starts. Has 10 TDs (9 pass, 1 rush) vs. 3 INTs & 98.5 rating in his past 5 home starts vs. Sea. Has won 6 of his past 7 home starts. • RB TREY BENSON had 51 scrimmage yards (42 rush, 9 rec.) in Week 3. • TE TREY MCBRIDE had 5 catches & 1st rec. TD of season last week, his 7thcareer TD catch. Aims for his 5th in row at home & 6th in row overall with 5+ catches. Had 7 catches for 70 yards in last meeting. • WR MARVIN HARRISON JR. has 40+ rec. yards in 4 of his past 5. • WR MICHAEL WILSON has rec. TD in 2 of his past 3 at home, incl. last meeting. • DE CALAIS CAMBPELL has 12.5 sacks & 17 TFL in 20 career games vs. Sea., incl. TFL in 3 of his past 4. Has 6 sacks & 11 TFL in 11 career Thursday games. • DL DALVIN TOMLINSON aims for his 3rd in row with TFL. • LB JOSH SWEAT had 45th-career sack last week & aims for his 3rd in row with sack. Has TFL in 3 of his past 4 on Thursday. Aims for his 3rd in row on Thursday with sack. • LB MACK WILSON set career highs with 12 tackles & 2 PD & had TFL in Week 3. Is only LB with PD in each of 1st 3 weeks & aims for his 5th in row with PD. • LB AKEEM DAVIS-GAITHER aims for his 3rd in row with 5+ tackles. • LB ZAVEN COLLINS has 6 TFL in his past 6 vs. Sea. • LB BARON BROWNING has 4 TFL in his past 4 at home. • S BUDDA BAKER had career-high 18 tackles in last meeting. Has 5+ tackles in 21 straight games, longest active streak by DB. Has 5 TFL & 5 PD in 6 career Thursday games, with 5+ tackles in each game. • S JALEN THOMPSON aims for his 9th in row with 6+ tackles. Aims for his 3rd in row on Thursday with PD. • S DADRION TAYLOR-DEMERSON had 1st-career INT last week
Game Odds
Seattle Seahawks – 1.5
Arizona Cardinals 43.5
Odds Courtesy of Sports Odd Direct as of Wednesday, September 24, 2025
