Venue & Game Details
Kickoff Time: 1:00 PM EDT / 12:00 PM CDT
Venue: Highmark Stadium, Orchard Park, New York
Capacity: ~71,600
Broadcast: CBS: Andrew Catalon, Charles Davis & Jason McCourty, AJ Ross (field reporter)
Weather Forecast (Orchard Park, NY)
Kickoff Temperature: ~68°F (20°C)
Conditions: Partly cloudy, mild breeze
Wind: 10–14 mph from the southwest
Precipitation: ~20% chance of light showers
Impact: Slight wind could affect special teams, otherwise excellent football weather.
Injury Report
New Orleans Saints:
QB Spencer Rattler – healthy, but struggling (3 INTs through 3 games).
RB Alvin Kamara – questionable (ankle).
WR Chris Olave – healthy, leads team in receiving.
LT Trevor Penning – questionable (knee).
CB Marshon Lattimore – questionable (hamstring).
Buffalo Bills:
QB Josh Allen – healthy, 8 TDs through 3 games.
WR Stefon Diggs – healthy, averaging 90+ ypg.
LB Matt Milano – questionable (shoulder).
S Micah Hyde – questionable (neck).
OT Dion Dawkins – questionable (ankle).
Key Player Matchups
Spencer Rattler (NO QB) vs. Bills Pass Rush
Rattler has been under heavy pressure, sacked 9 times.
Buffalo’s defense ranks top-5 in sacks.
Josh Allen (BUF QB) vs. Saints Secondary
Allen has spread the ball to 9 different receivers in Week 3.
Saints’ secondary has allowed 8 passing TDs already.
Alvin Kamara (NO RB) vs. Bills Run Defense
If healthy, Kamara is the Saints’ best chance to control tempo.
Bills allow just 92 rushing ypg.
Stefon Diggs (BUF WR) vs. Marshon Lattimore (NO CB)
If Lattimore plays, this is the marquee matchup.
Diggs has 3 TDs already this season.
Recent Team Form
New Orleans Saints (0–3)
L 13–44 @ Seahawks (Week 3)
L 17–27 vs. Panthers (Week 2)
L 17–19 @ Buccaneers (Week 1)
Strengths: Occasional flashes in the run game.
Weaknesses: Offense ranks 29th in scoring (15.7 ppg), defense allowing 30 ppg.
Buffalo Bills (3–0)
W 31–21 vs. Dolphins (Week 3)
W 27–17 @ Jets (Week 2)
W 34–14 vs. Patriots (Week 1)
Strengths: Balanced offense (Allen + Cook), opportunistic defense.
Weaknesses: Occasional slow starts in first halves.
Conference vs. Conference
Saints: NFC South
Bills: AFC East
Cross-conference matchup; Buffalo is a Super Bowl contender, New Orleans is in rebuild mode.
Series History
All-time series: Saints lead 7–5.
Last meeting: Bills won 31–6 on Thanksgiving Night, Nov. 25, 2021.
Trend: Buffalo snapped a 5-game losing streak to New Orleans in that 2021 win.
Betting Trends
New Orleans Saints:
0–3 ATS in 2025.
1–6 ATS in last 7 road games.
2 of last 3 games have gone Over.
Buffalo Bills:
3–0 ATS in 2025.
6–1 ATS in last 7 home games.
2 of last 3 games have gone Over.
Historical Betting Results
2021: Bills -6.5 covered in 31–6 win (Under cashed).
2017: Saints +3 covered in 47–10 win (Over cashed).
2013: Saints -10 covered in 35–17 win (Over cashed).
SAINTS NOTES
• QB SPENCER RATTLER had career-high 28 completions & TD pass in Week 3. Is only QB with 25+ completions in each of 1st 3 weeks & aims for his 5th in row with 25+ completions. Aims for his 3rd in row with 70+ comp. pct. • RB ALVIN KAMARA had 56 scrimmage yards (42 rush, 14 rec.) in Week 3 & aims for his 11th in row with 50+ scrimmage. yards. Had 138 scrimmage yards (106 rush, 32 rec.) & rush TD in his only career game at Buf. (11/12/17). Has 582 career catches & can surpass HOFer Marcus Allen (587) for 5th-most by RB all-time. Has 5+ catches in 5 of his past 6 on road. • TE JUWAN JOHNSON had 6 catches for 51 yards last week. Aims for his 3rd in row on road & 6th in row overall with 5+ catches. Ranks 2nd among TEs in receptions (19) & 5th in rec. yards (176) in 2025. • WR CHRIS OLAVE had career-high 10 catches for 57 yards last week. Aims for his 4th in row with 6+ catches & 50+ rec. yards. Ranks 2nd among WRs with 23 receptions in 2025. • DE CAMERON JORDAN has 9 TFL in his past 7 & aims for his 4th in row on road with TFL. • DE CARL GRANDERSON has 1.5+ sacks in 2 of 3 games this season. Had sack & 2 TFL in last meeting. • LB DEMARIO DAVIS had 11 tackles & TFL last week. Aims for his 9th in row with 8+ tackles. Has 8+ tackles in 8 of his past 9 vs. Buf., incl. 10+ tackles in 3 of his past 4. • LB PETE WERNER tied his career high with 13 tackles & had 3rd-career FR in Week 3. Has 5+ tackles in each of his past 15 games. • CB ALONTAE TAYLOR aims for his 3rd in row with PD. Has PD in 5 of his past 6 on road. • CB QUINCY RILEY (rookie) had 1st-career FF last week. • S JUSTIN REID aims for his 5th in row in reg. season vs. Buf. with 5+ tackles.
BILLS NOTES
• BILLS can begin 4-0 for the 1st time since 2020. Lead NFL with 420 yards per game & have 3rd-most points scored per game (34.0). Have won 13 straight reg. season home games, 2nd-longest streak in Buf. history. • QB JOSH ALLEN completed 22 of 28 atts. (78.6 pct.) for 213 yards & 3 TDs vs. 0 INTs with 134.1 rating & had 25 rush yards in Week 3. Has O INTs in 11 of his past 12 starts, incl. playoffs. Completed 23 of 28 atts. (82.1 pct.) for 260 yards & 4 TDs vs. 2 INTs with 115.2 rating & had 43 rush yards in last meeting. • RB JAMES COOK led team with 118 scrimmage yards (108 rush, 10 rec.) & had rush TD last week. Is 1 of 4 players with 100+ scrimmage yards in each game this season. Has TD in 7-straight games, longest active streak in NFL. • WR KHALIL SHAKIR had 4 catches for 45 yards & TD in Week 3. • WR ELIJAH MOORE had 41 scrimmage yards (30 rec., 11 rush) in Week 3. Had 6 catches for 66 yards & TD in his only game vs. NO (11/17/24 w/ Cle.). • WR JOSHUA PALMER had 2 catches for 72 yards in only career game vs. NO (10/27/24 w/ LAC). • TE DALTON KINCAID led team with 5 catches & 66 yards & had TD catch last week. Has TD catch in 2 of his past 3. • TE JACKSON HAWES (rookie) had 1st-career TD catch in Week 3. • DE GREG ROUSSEAU has PD in 3 of his past 4. Had 4 tackles in last meeting. • LB TERREL BERNARD had 7 tackles, TFL & 24-yard INT last week. Has TFL in 2 of his past 3. • DT ED OLIVER had 6 tackles, 3 TFL, sack & FF in Week 3. Has sack & FF in 3 of his past 4. Had 4 tackles, PD & half sack in last meeting. • CB TARON JOHNSON led team with 8 tackles & had TFL & PD last week. Had TFL in last meeting. • CB TRE’DAVIOUS WHITE had 5 tackles, TFL & PD in Week 3. Aims for his 3rd in row with TFL & PD. Has PD in both career games vs. NO.
Game Odds
New Orleans Saints 48.5
Buffalo Bills – 15.5
Odds Courtesy of Sports Odd Direct as of Saturday, September 27, 2025
