The Los Angeles Rams travel to Glendale for a divisional showdown against the Arizona Cardinals, where the Rams look to maintain their stranglehold on the NFC West and push toward a division title with a win. L.A., winners of seven of their last eight, boasts a top-5 offense fueled by Matthew Stafford’s veteran precision and Kyren Williams’ breakout ground game, but their secondary has sprung leaks lately (allowing 280+ pass yds in three straight). The Cardinals, limping through a six-game skid and all but eliminated from playoff contention, rely on Kyler Murray’s mobility to keep games competitive, though their defense ranks 29th in points allowed (27.8/g). This rematch of a Week 2 thriller (Rams won 30-28) could turn into a shootout if Arizona’s home-field energy sparks Murray, but the Rams’ balance and coaching edge under Sean McVay tilt toward a road victory in dome conditions.
Venue and Game Details
Location: State Farm Stadium, 1 Cardinals Drive, Glendale, AZ 85305. The retractable-roof stadium seats 63,400 and features a high-tech grass field that rolls in for games, with a vibrant Southwest atmosphere despite recent attendance dips.
Kickoff: 4:05 p.m. ET (2:05 p.m. local).
Broadcast: FOX: Kenny Albert, Jonathan Vilma, Megan Olivi (field reporter)
Local radio on 710 ESPN (LAR) and KMVP 98.7 FM (ARI).
Injury Report
Injuries mount for both squads, but the Cardinals’ secondary takes the heavier toll, potentially freeing Stafford for deep shots. Rams’ O-line holds steady. Latest from Tuesday, December 2 practice reports:
| Team | Player | Position | Injury | Practice Status | Est. Game Status |
| Rams | Cooper Kupp | WR | Ankle | Limited (Mon/Tue) | Questionable; rolled in Week 13, day-to-day—huge if out (82 rec, 1,012 yds, 7 TD). |
| Puka Nacua | WR | Knee | Full (Tue) | Probable; managed snaps last week, complements Atwell. | |
| Ernest Jones IV | LB | Shoulder | Limited | Questionable; tackling leader (89 tackles), run support key vs. Conner. | |
| Kobie Turner | DT | Knee | DNP (Mon); Limited (Tue) | Questionable; interior pressure (4 sacks). | |
| Blake Corum | RB | Ankle | Limited | Questionable; depth behind Williams. | |
| Cardinals | Garrett Williams | CB | Groin | DNP (Mon/Tue) | Out; missed two games, slot coverage void (No. 25 pass D without him). |
| Kyzir White | LB | Quad | DNP (Mon/Tue) | Doubtful; defensive captain (72 tackles), weakens box vs. Williams. | |
| BJ Ojulari | OLB | Knee | Limited (Tue) | Questionable; edge rusher (3 sacks), pass rush thins. | |
| Trey McBride | TE | Ribs | Full (Tue) | Probable; full go after scare—red-zone staple (55 rec, 612 yds). | |
| James Conner | RB | Knee | Limited | Questionable; volume RB if active (78 yds last week). |
Cardinals’ front seven vulnerable without White/Ojulari; Rams could see Kupp limited to 60% snaps.
Key Player Matchups
The Rams’ No. 4 scoring offense (28.1 pts/g) clashes with Arizona’s middling defense, but Murray’s legs test L.A.’s No. 18 rush D. Secondary gaps invite Stafford’s arm.
Matthew Stafford (LAR QB) vs. Cardinals Secondary (minus Williams)
Stafford (69% comp., 3,200 yds, 22 TD) exploits ARI’s No. 25 pass D (245 ypg allowed). Without Williams, slot routes open for Nacua (95 yds last game); Stafford’s 105 rating projects 300+ yds.
Kyler Murray (ARI QB) vs. Rams Front Seven (Jones?)
Murray (dual-threat: 2,100 pass yds, 500 rush) vs. LAR’s opportunistic line (No. 10 sacks). If Jones questionable, Murray’s scrambles (6.2 ypc) could net 60+ rush yds, but INT risk high (8-to-12 TD-INT).
Kyren Williams (LAR RB) vs. Cardinals Run D
Williams (1,300 yds, 5.4 ypc) meets ARI’s No. 20 stop unit (118 ypg allowed). Cardinals allow 4.5 ypc to RBs; Williams’ vision for 100+ yds in 22+ carries.
James Conner (ARI RB, if active) vs. Rams DL
Conner (950 yds, 4.8 ypc) vs. LAR’s No. 15 rush D (105 ypg allowed). Without White, creases form; Conner’s power projects 85+ if probable.
Puka Nacua/Demarcus Robinson (LAR WRs) vs. Cardinals CBs
Nacua (top-5 in rec yds) vs. Max Melton’s man coverage. If Kupp limited, targets surge; Cardinals fade often (No. 12 rate), opening YAC.
Team Records and Standings Context
Rams: 9-3 (1st NFC West, .750 win%). 3rd in NFC playoff picture. Offense: No. 4 passing (240/g), No. 8 rushing (125/g), T-4th pts (28.1/g). Defense: No. 14 pts allowed (22.4/g).
Cardinals: 3-9 (4th NFC West, .250 win%). 15th in NFC, eliminated. Offense: No. 20 passing (215/g), No. 18 rushing (110/g), T-22nd pts (21.2/g). Defense: No. 29 pts allowed (27.8/g).
Recent Team Forms
Rams surging with offensive firepower; Cardinals collapsing defensively.
Rams Last 5 Games (4-1):
| Date | Opponent | Result | Key Stats |
| Nov. 30 | @ SEA | W 27-16 | Stafford: 290 yds, 2 TD; Williams: 108 yds. |
| Nov. 23 | vs. SF | W 31-24 | Nacua: 132 yds; D forces late INT. |
| Nov. 16 | @ MIN | W 28-20 | Stafford: 310 yds, 3 TD; balanced attack. |
| Nov. 9 | vs. NO | L 34-13 | Secondary exposed (380 pass yds); turnovers. |
| Nov. 3 | @ MIA | W 38-24 | Williams: 145 yds, 2 TD; shootout win. |
Cardinals Last 5 Games (0-5):
| Date | Opponent | Result | Key Stats |
| Nov. 30 | vs. LAR | L 28-30 | Murray: 256 yds, TD; D allows 450 total yds. |
| Nov. 23 | @ HOU | L 20-31 | Conner: 78 yds; secondary torched. |
| Nov. 16 | vs. PIT | L 13-24 | Murray: 189 yds, 1 TD/2 INT; run D gashed. |
| Nov. 9 | @ SEA | L 17-28 | Offense sputters (17 pts); 3 TOs. |
| Nov. 2 | vs. CHI | L 27-10 | Murray limited (knee); D surrenders 300 yds. |
Rams 4-1 SU last 5; Cardinals 0-6 when allowing 25+ pts.
Series History
The Rams dominate the rivalry, winning 6 of last 7. All-time: Los Angeles leads 51-47-2 (including playoffs; LAR 3-1 postseason). Last 5 meetings:
Nov. 30, 2025: Rams 30, Cardinals 28 (LAR).
Sep. 29, 2024: Rams 27, Cardinals 20 (ARI).
Jan. 8, 2024 (Playoff): Cardinals 24, Rams 23 (ARI).
Dec. 31, 2023: Cardinals 16, Rams 12 (ARI).
Sep. 25, 2022: Rams 20, Cardinals 12 (LAR).
H2H avg. 42.6 total pts; overs hit 3/5 since 2022.
Betting Trends
Spread: Rams 8-4 ATS (67%); Cardinals 5-7 ATS (42%). LAR 4-2 ATS on road; ARI 2-4 ATS at home.
Total: Over in 7 of LAR’s 12 (58%); 6 of ARI’s 12 (50%). West div overs 62%.
Key Trends: Rams 7-1 SU last 8; Cardinals 0-5 when Murray <250 total yds. H2H: LAR 4-1 SU last 5.
Projected Score: Los Angeles Rams 28, Arizona Cardinals 20
RAMS NOTES:
• QB MATTHEW STAFFORD passed for 243 yards & 2 TDs in Week 13. Ranks 1st in NFL this season with 32 TDs, tied-4th with 266 comp. & 4th with 3,073 pass yards. Is 1 of 3 QBs (Jared Goff & Daniel Jones) in 2025 with a TD pass in 12 consecutive games. • RB BLAKE CORUM had team & career-high 81 rush yards & TD last week. • RB KYREN WILLIAMS had 72 rush yards & TD in Week 13. Has 70+ rush yards in 4 of his past 5 games & has rush TD in 4 of his past 5. • WR DAVANTE ADAMS had 2 red. TDs in Week 13 & has 117 career rec. TDs, 7th-most TD catches in NFL history. Leads the NFL with 14 rec. TDs this season & is the 5th player in NFL history to record 3+ seasons with 14+ TD catches. Has TD catch in six consecutive games, longest active streak in NFL this season. • WR PUKA NACUA had 72 rec. yards in Week 13 & has 70+ rec. yards in 4 of his past 5. Had 10 receptions for 129 yards in last meeting. • WR XAVIER SMITH led team with season-high 82 rec. yards in Week 13. • TE COLBY PARKINSON has TD catch in 3 of his past 4. • LB NATE LANDMAN co-led team with 8 tackles last week. Aims for 5th in row with 7+ tackles. Has TFL in 2 of his past 3 on road. Had 8 tackles, sack & INT in his last meeting (11/12/23 w/ Atl.). • LB BYRON YOUNG co-led team with 8 tackles & sack in Week 13. Has sack in 5 of his past 6 on road. Aims for 4th in row with TFL vs. Ari. • LB OMAR SPEIGHTS has 7+ tackles in 3 of his past 4. Had 10 tackles in last meeting. • DE BRADEN FISKE had season-high 6 tackles, 2 TFL & sack last week. • CB EMMANUEL FORBES has PD in 4 of his past 5. • S KAMREN KINCHENS had 6 tackles in Week 13 & aims for 3rd in row with 6+ tackles. Has PD in 2 of his past 3. • S KAM CURL aims for 4th in row with 8+ tackles vs. Ari.
CARDINALS NOTES:
• QB JACOBY BRISSETT passed for 301 yards & 2 TDs for a 100.1 rating in Week 13. Has 250+ pass yards & TD in all 7 starts this season. Ranks 1st with 2,188 pass yards, 1st with 204 comp. & tied-5th with 13 TD passes since Week 6. Aims for 4th in row with 300+ pass yards & TD. Had 2 TD passes in his last meeting (12/17/23 w/ Was.). • RB BAM KNIGHT had 98 scrimmage yards (62 rush, 36 rec.) & rec. TDs in Week 13. Aims for 4th in row with scrimmage TD. • WR MARVIN HARRISON JR. had 6 receptions for 69 yards last week. Has 50+ rec. yards in 3 of his past 4 & TD catch in 2 of his past 3. • WR GREG DORTCH has scrimmage TD in 3 of his past 4. • TE TREY MCBRIDE had team-high 8 catches for 82 yards & TD in Week 13, his 14th consecutive game with 5+ receptions, 2nd-longest (Travis Kelce – 15 straight in 2018) such streak by TE in NFL history. Has 309 career receptions, the most by TE in 1st 4 seasons in NFL history. Leads TEs with 88 receptions, 879 rec. yards & 8 TD catches in 2025 & is the 6th TE in NFL history with 80+ receptions & 800+ rec. yards in 3 straight seasons. • LB JOSH SWEAT had 2 sacks & FF in Week 13. Has sack in 4 of his past 5. Ranks tied-4th with 11 sacks this season. Has TFL in 5 of his past 6 at home. Had sack & TFL in his last meeting (11/24/24 w/ Phi.). • LB AKEEM DAVIS-GAITHER led team with season-high 10 tackles last week. • LB CODY SIMON (rookie) had 9 tackles in Week 13 & aims for 4th in row with 7+ tackles. • S BUDDA BAKER had 9 tackles & PD last week. Aims for 4th in row at home with 8+ tackles. Has 7+ tackles in 4 of his past 5 vs. LAR. Is only S since 2017 with 900+ tackles (970) & 10+ sacks (10). • S JALEN THOMPSON had 2 PD in Week 13 & aims for 4th in row with PD. Has 5+ in 4 of his past 5 games.
Game Odds
Los Angeles Rams – 7.5
Arizona Cardinals 48.5
Odds Courtesy of Sports Odd Direct as of Saturday, December 6, 2025
