Venue & Event Details
Stadium: State Farm Stadium, Glendale, Arizona
Kickoff: 4:05 PM ET / 1:05 PM PT
Broadcast: CBS: Spero Dedes, Adam Archuleta, Aditi Kinkhabwala (field reporter)
Weather Updates
Forecast: Mild day with overcast skies
Stadium: Retractable roof minimizes wind impact, ensuring controlled conditions.
Injury Report
Jacksonville Jaguars:
WR Zay Jones – Out (season-ending injury)
CB Tyson Campbell – Questionable (hamstring)
Arizona Cardinals:
QB Kyler Murray – Out (season-ending injury)
RB James Conner – Out (injured reserve)
WR Zay Jones (recently acquired) – Out
Several depth players on IR, limiting offensive options
Player Matchups
QB Battle:
Trevor Lawrence (JAX) – Projected 218.7 passing yards, 1.5 TDs
Jacoby Brissett (ARI) – Projected 244.8 passing yards, 1.9 TDs
Skill Players:
Travis Etienne Jr. (JAX) – Expected 62.1 rushing yards, key red-zone threat
Trey McBride (ARI) – Projected 74 receiving yards, primary target
Team Recent Form
Jacksonville Jaguars:
Road Record: 2–2
Last Game: Defeated Chargers 35–6
Strength: Balanced offense, improving defense.
Arizona Cardinals:
Home Record: 1–4
Last Game: Lost to 49ers despite Brissett’s 452 passing yards
Weakness: Injuries, poor division record (0–4).
Series History
Jaguars vs Cardinals all-time: Cardinals lead 4–3.
Last meeting: Jaguars lost 31–19 in 2021.
Betting Trends:
Jaguars: 6–4 ATS this season; strong road performance.
Cardinals: 1–4 at home; struggling to cover spreads.
Over has hit in recent games for both teams (JAX scored 35 last week, ARI games trending high-scoring).
JAGURS NOTES:
• JAGUARS recorded 4 rush TDs last week, 1st game with 4+ rush TDs since Week 3 of the 2009 season. • QB TREVOR LAWRENCE had 153 pass yards & 2 TDs (1 pass, 1 rush) in Week 11. Since entering NFL in 2021, has 4th-most rushing TDs by QB with 19. Has pass TD in 6 of his past 7 games. Has rush TD in 2 of his past 3 games. Had 219 pass yards & TD in last meeting. • RB TRAVIS ETIENNE had 73 rush yards & 2 TDs in Week 11. Is 1 of 5 RBs in 2025 to record 10+ games of 50+ scrimmage yards. Aims for 4th in row with 50+ rushing yards. Aims for 3rd in row with rush TD. • RB BHAYSHUL TUTEN (rookie) had a career-high 74 rush yards & 3rd-career rush TD in Week 11. • WR JAKOBI MEYERS led team with 5 catches & 64 yards in Jax. debut in Week 11. Has 3+ catches in all 9 games played in 2025. Had 5 catches for 52 yards in his last game vs. Ari. (11/29/20 w/ NE). • DE JOSH HINES-ALLEN had 4 tackles, sack & PD in Week 11. With sack last week, set new franchise record with 56 career sacks. Has TFL in 2 of his past 3 road games. • DT ARIK ARMSTEAD had 3 tackles, 2 TFL & sack in Week 11. Aims for 5th in row on road with TFL. Aims for 3rd in row with sack. Has sack in 3 of his past 4 games on road. • LB FOYE OLUOKUN had 5 tackles & 2 PD in Week 11. Has career-high 8 PD in 2025. Is 1 of 2 in 2025 (Tremaine Edmunds) to record 80+ tackles & 8 PD. Has 7+ tackles in 9 consecutive road games, longest active streak in NFL. Aims for 6th in row with PD. • S ANDREW WINGARD had 5 tackles & PD in Week 11. Ranks tied-4th for longest active streak by DB with 5+ tackles in 8 consecutive games. Has PD in 5 of his past 6 games on road
CARDINALS NOTES:
• QB JACOBY BRISSETT completed 47 of 57 pass att. (82.5 percent) for 452 yards & 2 TDs in Week 11. His 47 completions were the most in a regular-season game in NFL history & tied Ben Roethlisberger (2020 AFC-WC) for the most completions in a game, including the postseason, all-time. Since 1st start in Week 6, ranks 1st with 142 completions & 2nd with 1,570 pass yards. Aims for 6th in row with 250+ pass yards & 2+ TDs. • RB BAM KNIGHT had 45 scrimmage yards (24 rush, 21 rec.) & rush TD in Week 11. Has 40+ scrimmage yards in 4 of his past 5 games. • WR GREG DORTCH had 6 catches for 66 yards & TD in Week 11. Aims for 3rd in row with scrimmage TD. Has scrimmage TD in 2 of his past 3 road games. • WR MICHAEL WILSON set career-highs with 15 catches for 185 yards last week. His 185 rec. were the most by a player in a game in 2025 & his 15 receptions were the 2nd most. Has 40+ receiving yards in 4 of his past 5 games. • TE TREY MCBRIDE had 10 catches for 115 yards & TD in Week 11. Became the 3rd TE in NFL history with 5+ receptions in 12+ consecutive games, joining Travis Kelce (15, 2018) & HOFer Tony Gonzalez (13, 2008-09). Became 2nd TE with 5+ receptions, 50 receiving yards & TD in 5+ consecutive games in single season, joining HOFer Antonio Gates (2010). Leads TEs with 71 catches & 718 receiving yards & ranks tied-1st with 7 TDs. • LB JOSH SWEAT had sack last week. Ranks tied-4th in 2025 with 9 sacks. Is 1 of 3 (Will Anderson & Brian Burns) to record 2 streaks of 3+ games with sack in 2025. Aims for 4th in row with sack. • LB CODY SIMON (rookie) had career-high 12 tackles in Week 11. • S BUDDA BAKER had 8 tackles last week. Has 28 straight games with 5+ tackles, tied-2nd longest active streak in NFL. • S JALEN THOMPSON had 5 tackles & PD in Week 11. Aims for 8th in row with 5+ tackles on road.
Game Odds
Jacksonville Jaguars – 2.5
Arizona Cardinals 47.5
Odds Courtesy of Sports Odd Direct as of Saturday, November 22, 2025
