Venue & Game Details
Kickoff Time: 4:05 PM EDT / 1:05 PM PDT
Venue: Levi’s Stadium, Santa Clara, California
Capacity: ~68,500
Broadcast: FOX: Adam Amin, Mark Sanchez, Kristina Pink (field reporter)
Weather Forecast (Santa Clara, CA)
Kickoff Temperature: ~77°F (25°C)
Conditions: Sunny, light clouds
Wind: 7–10 mph from the northwest
Precipitation:
Impact: Ideal Bay Area football weather; no disruptions expected.
Injury Report
Jacksonville Jaguars:
QB Trevor Lawrence – healthy, 671 yards, 4 TDs, 4 INTs through 3 games.
RB Travis Etienne Jr. – healthy, 270 yards rushing, 1 TD.
WR Brian Thomas Jr. – healthy, emerging as a deep threat.
CB Tyson Campbell – questionable (hamstring).
San Francisco 49ers:
QB Brock Purdy – questionable (turf toe); Mac Jones has started last two games.
DE Nick Bosa – out for season (torn ACL).
TE George Kittle – questionable (ankle).
WR Jauan Jennings – questionable (hamstring).
OG Ben Bartch – questionable (knee).
Key Player Matchups
Trevor Lawrence (JAX QB) vs. 49ers Secondary
Lawrence has been inconsistent but dangerous when protected.
49ers’ secondary has allowed just 16.3 ppg, anchored by Fred Warner’s leadership.
Christian McCaffrey (SF RB) vs. Jaguars Front Seven
McCaffrey leads SF with 176 rushing yards.
Jaguars’ defense has forced 9 turnovers this season, tops in the NFL.
Travis Etienne Jr. (JAX RB) vs. 49ers Run Defense
Etienne averaging 90 ypg.
49ers allowing just 89.7 rushing ypg.
A.J. Terrell (JAX CB) vs. Ricky Pearsall (SF WR)
Pearsall has been a reliable target with 250+ yards.
Jaguars’ secondary has been opportunistic with multiple INTs.
Recent Team Form
Jacksonville Jaguars (2–1)
W 17–10 vs. Texans (Week 3)
L 20–27 vs. Bengals (Week 2)
W 24–17 vs. Colts (Week 1)
Strengths: Opportunistic defense, balanced run-pass attack.
Weaknesses: Lawrence’s turnovers, inconsistent red-zone efficiency.
San Francisco 49ers (3–0)
W 16–15 vs. Cardinals (Week 3)
W 23–20 vs. Saints (Week 2)
W 27–24 vs. Bears (Week 1)
Strengths: Resilient defense, clutch late-game execution.
Weaknesses: Injuries to key stars, offense limited without Purdy.
Conference vs. Conference
Jaguars: AFC South
49ers: NFC West
Cross-conference matchup; no direct playoff tiebreaker impact, but a strong test for both teams.
Series History
All-time series: 49ers lead 5–2.
Last meeting: 49ers beat Jaguars 34–3 in Jacksonville (Nov. 21, 2021).
Trend: San Francisco has won 5 straight vs. Jacksonville.
Betting Trends
Jacksonville Jaguars:
2–1 ATS in 2025.
0–6 ATS in last 6 vs. NFC West opponents.
4 of last 6 games have gone Under.
San Francisco 49ers:
2–1 ATS in 2025.
9–2 ATS in last 11 following a division win.
5–0 SU in last 5 vs. Jaguars.
Historical Betting Results
2021: 49ers -6.5 covered in 34–3 win (Under cashed).
2017: 49ers +4.5 upset Jaguars 44–33 (Over cashed).
2009: 49ers -3 covered in 20–3 win (Under cashed).
JAGUARS NOTES
• QB TREVOR LAWRENCE aims for 3rd in row with 220+ pass yards. Has 2+ TD passes in 3 of his past 4 road starts. • RB TRAVIS ETIENNE had 56 rush yards & 1st rush TD of season last week. Aims for his 6th in row with 55+ scrimmage yards & 3rd in row with TD. Is 1 of 6 in NFL with both rush TD & rec. TD this season. • RB BHAYSHUL TUTEN (rookie) had 1st-career rush TD in Week 3. Aims for 3rd in row with TD. Is 1 of 6 in NFL with both rush TD & rec. TD this season. • WR BRIAN THOMAS JR. had season-high 55 rec. yards last week. Has 5+ catches & 80+ rec. yards in 4 of his past 5 on road. Needs 6 catches for 100th-career catch. • WR PARKER WASHINGTON aims for 3rd in row with 4+ catches. Has 50+ rec. yards in 2 of his past 3 on road. • TE BRENTON STRANGE led team with season highs in catches (6) & rec. yrds (61) last week. Has 55+ rec. yards in 3 of his past 4. • WR/DB TRAVIS HUNTER (rookie) had season-high 6 tackles last week. • DE JOSH HINES-ALLEN had half sack & PD in Week 3. • DT ARIK ARMSTEAD aims for 3rd in row with 0.5+ sacks. Has sack in 2 of his past 3 on road. Facing SF for 1st time after spending 1st 9 career seasons (2015-23) with team, totaling 33.5 sacks. • LB FOYESADE OLUOKUN aims for his 9th in row with 5+ tackles. Has PD in 2 of past 3. Had 9 tackles, 3 TFL & 2 sacks in last meeting. • DE TRAVON WALKER aims for 3rd in row with sack. Had PD in last meeting. • CB TYSON CAMPBELL led team with 7 tackles & had PD & 3rd-career FF in Week 3. Is 1 of 4 in NFL with 5+ tackles & PD in each of 1st 3 weeks of season. • CB JOURDAN LEWIS had 2 PD & 2nd INT of season last week. Aims for his 5th in row with PD. Leads NFL with 6 PD this season. • S ANTONIO JOHNSON had 3rd-career INT in Week 3.
49ERS NOTES
• QB BROCK PURDY passed for 296 yards & 3 TDs vs. 0 INTs for 148.9 rating in last meeting. Has 2+ TD passes in each of his past 3 starts. • QB MAC JONES aims for his 3rd in row with 275+ pass yards & TD pass. Appeared in 10 games (7 starts) with Jax. in 2024 & had 1,672 pass yards & 9 TDs (8 pass, 1 rush). Passed for 3 TDs vs. 0 INTs for 128.1 rating in his only career start vs. Jax. (1/2/22 w/ NE). • RB CHRISTIAN MCCAFFREY had 10 catches & 140 scrimmage yards (88 rec., 52 rush) in Week 3, his 12th-career game with 10+ catches, most by RB in NFL history. Leads all RBs with 25 receptions & ranks 3rd in NFL with 389 scrimmage yards in 2025. Has 379 scrimmage yards (189.5 per game) & 3 TDs (2 rush, 1 rec.) in 2 career games vs. Jax. Aims for his 4th in row with 50+ rush yards & 50+ rec. yards. • FR KYLE JUSZCZYK had 19th-career rec. TD last week. Has rec. TD in 3 of his past 5. Had TD catch in last meeting. • WR RICKY PEARSALL tied his career high with 8 receptions & had 117 rec. yards in Week 3, his 3rd-career 100-yard game. Aims for his 6th in row with 50+ rec. yards. • WR JAUAN JENNINGS has 5+ catches & 50+ rec. yards in 3 of his past 4. • LB FRED WARNER led team with 11 tackles & had 2 PD last week. Since 2018, leads all LB with 56 PD. Has TFL in 4 of his past 5. Had INT in last meeting. • LB DEE WINTERS aims for his 7th in row with 6+ tackles. • DL BRYCE HUFF had 22nd-career sack last week & aims for his 3rd in row with sack. • DL MYKEL WILLIAMS leads all rookies with 3 TFL & aims for his 3rd in row with TFL. • CB UPTON STOUT (rookie) has PD in 2 of 3 career games. • CB DEOMMODORE LENOIR aims for his 3rd in row with TFL.
Game Odds
Jacksonville Jaguars 47.5
San Francisco 49ers – 3.5
Odds Courtesy of Sports Odd Direct as of Saturday, September 27, 2025
