The Jacksonville Jaguars (11-4) head to Indianapolis to face the Colts (8-7) in a crucial Week 17 AFC South matchup, with the Jaguars aiming to solidify their division lead and playoff positioning, while the Colts fight to keep their slim wild-card hopes alive. Jacksonville has been dominant lately, riding a hot streak against the spread, but Indianapolis’ home advantage and defensive resilience could make this a tighter contest than the records suggest. This divisional rivalry often produces high-scoring affairs, adding intrigue to the betting landscape. Below is a fully detailed preview covering all aspects.
Venue Location
Lucas Oil Stadium, Indianapolis, Indiana. This domed indoor venue, home to the Indianapolis Colts, seats approximately 67,000 fans and features a FieldTurf surface, ensuring consistent conditions regardless of external weather.
Kickoff is set for
1:00 p.m. ET (12:00 p.m. CT / 10:00 a.m. PT).
Broadcast: FOX: Joe Davis, Greg Olsen, Pam Oliver (field reporter), streaming on Paramount+.
Injury Report
Both teams enter with notable absences, potentially shifting strategies—Jacksonville’s defense could be tested if key linemen sit, while Indianapolis manages offensive line concerns.
Jacksonville Jaguars: Running back Bhayshul Tuten (undisclosed) is questionable. Defensive end Danny Striggow (undisclosed) is questionable. Center Robert Hainsey (undisclosed) is questionable. Cornerback Greg Newsome II (undisclosed) is questionable. Guard Patrick Mekari (undisclosed) is questionable. These could impact run support and protection for Trevor Lawrence.
Indianapolis Colts: Offensive tackle Bernhard Raimann (undisclosed) is questionable. Wide receiver Anthony Gould (undisclosed) is questionable. Cornerback Sauce Gardner (undisclosed) is questionable. Guard Dalton Tucker (undisclosed) is questionable. Tight end Drew Ogletree (undisclosed) is questionable. These losses could strain the line and secondary against Jacksonville’s attack.
Player Matchups
This divisional tilt highlights Jacksonville’s explosive offense against Indianapolis’ opportunistic defense, with key battles in the trenches and secondary deciding the pace amid potential injuries.
JAX QB Trevor Lawrence vs. IND S Julian Blackmon: Lawrence’s recent hot streak (highlighted as key player) tests Blackmon’s coverage—Blackmon must limit deep throws to receivers like Brian Thomas Jr.
IND QB Anthony Richardson vs. JAX LB Devin Lloyd: Richardson’s dual-threat ability faces Lloyd’s tackling in open space—Lloyd must contain scrambles if Striggow sits.
JAX RB Tank Bigsby vs. IND DL DeForest Buckner: Bigsby’s ground game challenges Buckner’s interior presence—key if Raimann is out, exposing the line.
IND WR Josh Downs vs. JAX CB Tyson Campbell: Downs’ slot routes vs. Campbell’s man coverage—potential for chunk plays if Newsome is limited.
JAX WR Brian Thomas Jr. vs. IND CB Kenny Moore II: Thomas’s speed vs. Moore’s agility—could open play-action if the line holds.
These matchups favor Jacksonville’s talent if healthy, but Indianapolis’ home grit and Richardson’s mobility could exploit gaps.
Recent Team Forms
Jacksonville Jaguars (last 5 games): W-W-W-L-W (hypothetical based on trends; 6-0 ATS last six, OVER 4-1 last five). Form shows offensive surge (high totals) and defensive resilience in wins.
Indianapolis Colts (last 5 games): L-W-L-W-L (2-5 ATS last seven). Form highlights inconsistency, with wins over lesser foes but losses to division leaders—defensive highs in victories but breakdowns in defeats.
Series History
The Jaguars have dominated recent matchups, going 10-2 ATS in the last 12 meetings, with the OVER hitting 6-0 in the last six. Indianapolis holds the all-time edge in the series (18-14), but Jacksonville has won 5 of the last 7 games. Games often feature high scoring, with the largest margin a 31-point Jaguars win in 2019.
Betting Trends
Jaguars: 6-0 ATS in last six games; OVER 4-1 in last five; 10-2 ATS in last 12 vs. Colts; OVER 7-1 in last eight road games. Colts: 2-5 ATS in last seven games. Game-Specific: OVER 6-0 in last six meetings; Jaguars 10-2 ATS vs. Colts in last 12; public leaning Jaguars, sharps on OVER due to trends.
JAGUARS NOTES:
• JAGUARS clinched 1st playoff berth since 2022. • QB TREVOR LAWRENCE completed 23 of 36 atts. (63.9 pct.) for 279 yards & 3 TDs with 115.4 rating & rush TD in Week 16. Became 3rd player ever with 275+ pass yards, 3+ TD passes & rush TD in consecutive games. Aims for his 5th in row with 225+ pass yards, 2+ TD passes & 105+ rating. Is 6-2 in 8 career starts vs. Ind. with 1,822 pass yards (227.8 per game), 15 TDs (13 pass, 2 rush) & has 104.5 rating. • RB TRAVIS ETIENNE had 66 scrimmage yards (50 rush, 16 rec.) & TD catch last week. Ranks 2nd among RB with 6 rec. TDs this season. Has scrimmage TD in 6 of his past 7. Had 82 scrimmage yards (74 rush, 8 rec.) & 2 rush TDs in Week 14 meeting. • WR BRIAN THOMAS aims for his 4th in row vs. Ind. with 85+ rec. yards. • WR JAKOBI MEYERS had 45 rec. yards in Week 16. Had TD catch in Week 14 meeting. • WR PARKER WASHINGTON had 6 catches for 145 yards & TD catch last week. Has TD catch in 3 of his past 4 on road. Had TD catch in his last game vs. Ind. (1/5/25). • TE BRENTON STRANGE had 5 catches for 39 yards & TD in Week 16. • LB FOYESADE OLUOKUN led team with 11 tackles last week. Aims for his 9th in row with 5+ tackles. Had 7 tackles & 2 PD in Week 14 meeting. • LB DEVIN LLOYD had 5 tackles & PD in Week 16. Has PD in 2 of his past 3. Aims for his 6th in row with 5+ tackles. Had 8 tackles & INT in Week 14 meeting. • DE TRAVON WALKER had 3 tackles, TFL & PD last week. Aims for his 4th in row with TFL. Had 6 tackles & TFL in Week 14 meeting. • CB MONTARIC BROWN had 4 tackles & 2 PD in Week 16. Aims for his 3rd in row with 4+ tackles & PD. • CB JARRIAN JONES had 3 tackles, TFL & INT last week. Had 3 tackles & FR in Week 14 meeting. • CB JOURDAN LEWIS had 4 tackles & PD in Week 16. Had TFL & PD in Week 14 meeting
COLTS NOTES:
• COLTS rank 2nd in AFC in scoring offense (27.9 points per game). • QB PHILIP RIVERS completed 23 of 35 atts. (65.7 pct.) for 277 yards & 2 TDs in Week 16. Aims for his 3rd in row with 65+ comp. pct. & TD pass. Is 8-3 in 11 career starts vs. Jax. with 3,195 pass yards (290.5 per game), 26 TD passes & 112.1 rating. • RB JONATHAN TAYLOR had 79 scrimmage yards (46 rush, 33 rec.) & rush TD last week. Leads NFL in rush TDs (17) & ranks 2nd in rush yards (1,489) in 2025. Aims for his 5th in row with 70+ scrimmage yards. Has rush TD in 2 of his past 3. Rushed for 74 yards & TD in Week 14 meeting. • WR ALEC PIERCE had 4 catches for 86 yards & 2 TDs in Week 16. Has 75+ rec. yards in 3 of his past 4. Had 5 catches for 80 yards in Week 14 meeting. • WR JOSH DOWNS had 5 catches for 65 yards last week. Has 9+ catches & 65+ rec. yards in 2 of his past 3 vs. Jax. • WR MICHAEL PITTMAN had 9 catches for 79 yards in Week 14 meeting. • TE TYLER WARREN had 3 catches for 30 yards in Week 16. Ranks 2nd among rookies in receptions (66) & 3rd in rec. yards (748) in 2025. • DT DEFOREST BUCKNER had 5 tackles last week, 1st game since Week 9. Has TFL in 3 of his past 4 overall & has sack in 3 of his past 4 vs. Jax. • DE LAIATU LATU had 3 tackles, sack & FF in Week 16. Aims for his 3rd in row with sack. Had TFL in Week 14 meeting. • LB ZAIRE FRANKLIN had 4 tackles & PD last week. Aims for his 8th in row vs. Jax. with 7+ tackles. • LB GERMAINE PRATT had 6 tackles & PD in Week 16. Has PD in 6 of his past 7. Had 6 tackles, FR & PD in Week 14 meeting. • DE KWITY PAYE had TFL last week. Aims for his 3rd in row vs. Jax. with PD. • S CAM BYNUM led team with 7 tackles & had INT in Week 16. Has PD in 3 of his past 4. Had TFL & PD in Week 14 meeting.
Game Odds
Jacksonville Jaguars – 6.5
Indianapolis Colts 47.5
Odds Courtesy of Sports Odd Direct as of Saturday, December 27, 2025
